Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice

(2018) Albert G. Linden et al.   JOURNAL OF LIPID RESEARCH

Liver X receptors in lipid signalling and membrane homeostasis

(2018) Bo Wang et al.   Nature Reviews Endocrinology

High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype

(2018) Nicole Golob-Schwarzl et al.   Translational Oncology

The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids

(2017) Puneet Puri et al.   HEPATOLOGY

New trends on obesity and NAFLD in Asia

(2017) Jian-Gao Fan et al.   JOURNAL OF HEPATOLOGY

Meta-analysis on shift work and risks of specific obesity types

(2017) M. Sun et al.   Obesity Reviews

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance

(2017) Max C. Petersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway

(2017) Hsu-Wen Chao et al.   Nature Communications

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

The Metabolic Syndrome and Its Influence on Nonalcoholic Steatohepatitis

(2016) Pushpjeet Kanwar et al.   Clinics in Liver Disease

Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in the United States and the Rest of the World

(2016) Mehmet Sayiner et al.   Clinics in Liver Disease

Rhythm and bugs

(2016) Andrew E. Rosselot et al.   CURRENT OPINION IN GASTROENTEROLOGY

A “systems medicine” approach to the study of non-alcoholic fatty liver disease

(2016) Salvatore Petta et al.   DIGESTIVE AND LIVER DISEASE

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Night shift work and incidence of diabetes in the Danish Nurse Cohort

(2016) Anne B Hansen et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis

(2016) Mark A. Herman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock

(2016) Fabin Dang et al.   Nature Communications

The emerging roles of lipids in circadian control

(2015) Yaarit Adamovich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies

(2015) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

(2015) Amedeo Lonardo et al.   DIGESTIVE AND LIVER DISEASE

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

(2015) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids

(2015) Daniel F. Vatner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans

(2015) Christopher J. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian rhythms in liver metabolism and disease

(2015) Jessica M. Ferrell et al.   Acta Pharmaceutica Sinica B

Fatty acid sources and their fluxes as they contribute to plasma triglyceride concentrations and fatty liver in humans

(2014) M. Miriam Jacome-Sosa et al.   CURRENT OPINION IN LIPIDOLOGY

Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease

(2014) Un Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sterol Regulatory Element-binding Protein (SREBP) Cleavage Regulates Golgi-to-Endoplasmic Reticulum Recycling of SREBP Cleavage-activating Protein (SCAP)

(2014) Wei Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease

(2014) Thomas Svava Nielsen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of hepatic steatosis by dietary fatty acids

(2014) Alessandra Ferramosca   WORLD JOURNAL OF GASTROENTEROLOGY

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Circadian Disruption Leads to Insulin Resistance and Obesity

(2013) Shu-qun Shi et al.   CURRENT BIOLOGY

Dual Peroxisome Proliferator-Activated Receptor  /  Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects

(2013) B. Cariou et al.   DIABETES CARE

The multifaceted role of mTORC1 in the control of lipid metabolism

(2013) Stéphane J H Ricoult et al.   EMBO REPORTS

Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials

(2012) G. Musso et al.   DIABETOLOGIA

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

Sirtuin 1 Regulates SREBP-1c Expression in a LXR-Dependent Manner in Skeletal Muscle

(2012) Aurélia Defour et al.   PLoS One

Coordination of the transcriptome and metabolome by the circadian clock

(2012) K. L. Eckel-Mahan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Fatty acid synthase and liver triglyceride metabolism: Housekeeper or messenger?

(2011) Anne P.L. Jensen-Urstad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Predicting insulin resistance using the triglyceride-to-high-density lipoprotein cholesterol ratio in Taiwanese adults

(2011) Jui-Kun Chiang et al.   Cardiovascular Diabetology

Crosstalk between Components of Circadian and Metabolic Cycles in Mammals

(2011) Gad Asher et al.   Cell Metabolism

Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease

(2011) Romina Lomonaco et al.   HEPATOLOGY

Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: A systematic review

(2011) Christian Thoma et al.   JOURNAL OF HEPATOLOGY

Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression

(2011) Yun-Seung Jeong et al.   PLoS One

PER2 Controls Lipid Metabolism by Direct Regulation of PPARγ

(2010) Benedetto Grimaldi et al.   Cell Metabolism

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

Adiponectin isoforms, insulin resistance and liver histology in nonalcoholic fatty liver disease

(2010) Giampaolo Bianchi et al.   DIGESTIVE AND LIVER DISEASE

Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease

(2010) P. Dongiovanni et al.   GUT

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

(2010) Suneil K. Koliwad et al.   JOURNAL OF CLINICAL INVESTIGATION

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

(2010) Eric E Zhang et al.   NATURE MEDICINE

Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice

(2010) Susie Lee et al.   PLoS One

Histopathology of Non-Alcoholic Fatty Liver Disease

(2009) Elizabeth M. Brunt   Clinics in Liver Disease

Interrelationship between Liver X Receptor α, Sterol Regulatory Element-binding Protein-1c, Peroxisome Proliferator-activated Receptor γ, and Small Heterodimer Partner in the Transcriptional Regulation of Glucokinase Gene Expression in Liver

(2009) Tae-Hyun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Enhances Post-translational Processing of Nascent SREBP-1c by Promoting Its Phosphorylation and Association with COPII Vesicles

(2009) Chandrahasa R. Yellaturu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Enhances the Biogenesis of Nuclear Sterol Regulatory Element-binding Protein (SREBP)-1c by Posttranscriptional Down-regulation of Insig-2A and Its Dissociation from SREBP Cleavage-activating Protein (SCAP)·SREBP-1c Complex

(2009) Chandrahasa R. Yellaturu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid regulation of the circadian clock modulates glucose homeostasis

(2009) A. Y.-L. So et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipolysis and lipid mobilization in human adipose tissue

(2009) Max Lafontan et al.   PROGRESS IN LIPID RESEARCH

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

(2009) Gwendal Le Martelot et al.   PLOS BIOLOGY

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SREBPs: the crossroads of physiological and pathological lipid homeostasis

(2008) Rajendra Raghow et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM