标题
HIF-α factors as potential therapeutic targets in leukemia
作者
关键词
-
出版物
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 22, Issue 11, Pages 917-928
出版商
Informa UK Limited
发表日期
2018-10-20
DOI
10.1080/14728222.2018.1538357
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring
- (2018) Elias Jabbour et al. AMERICAN JOURNAL OF HEMATOLOGY
- HIF2 Inhibitor Joins the Kidney Cancer Armamentarium
- (2018) William G. Kaelin JOURNAL OF CLINICAL ONCOLOGY
- Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma
- (2018) Kevin D. Courtney et al. JOURNAL OF CLINICAL ONCOLOGY
- New horizons in hypoxia signaling pathways
- (2017) Christopher W. Pugh et al. EXPERIMENTAL CELL RESEARCH
- mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene (HIF1A): An independent predictor of poor overall survival in chronic lymphocytic leukemia
- (2017) Christos K. Kontos et al. LEUKEMIA RESEARCH
- Integration of hypoxic HIF-α signaling in blood cancers
- (2017) L Schito et al. ONCOGENE
- Acute lymphoblastic leukemia: a comprehensive review and 2017 update
- (2017) T Terwilliger et al. Blood Cancer Journal
- Chronic lymphocytic leukaemia
- (2017) Thomas J. Kipps et al. Nature Reviews Disease Primers
- Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer
- (2017) Luisa Iommarini et al. Frontiers in Oncology
- Hypoxia-inducible factor 3 biology: complexities and emerging themes
- (2016) Cunming Duan AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Adult hematopoietic stem cells lacking Hif-1 self-renew normally
- (2016) M. Vukovic et al. BLOOD
- HIF-1 regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment
- (2016) R. Valsecchi et al. BLOOD
- Pioglitazone together with imatinib in chronic myeloid leukemia: A proof of concept study
- (2016) Philippe Rousselot et al. CANCER
- A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma
- (2016) Eli M. Wallace et al. CANCER RESEARCH
- Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact
- (2016) Kevin Rouault-Pierre et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Targeting renal cell carcinoma with a HIF-2 antagonist
- (2016) Wenfang Chen et al. NATURE
- On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
- (2016) Hyejin Cho et al. NATURE
- Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
- (2016) Caroline Wigerup et al. PHARMACOLOGY & THERAPEUTICS
- ‘Acute myeloid leukemia: a comprehensive review and 2016 update’
- (2016) I De Kouchkovsky et al. Blood Cancer Journal
- Hypoxia inducible factor-1α regulates a pro-invasive phenotype in acute monocytic leukemia
- (2016) Jessica Migliavacca et al. Oncotarget
- Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
- (2016) Salminen Antero et al. Aging and Disease
- Hypoxia and Hypoxia-Inducible Factors in Leukemias
- (2016) Margaux Deynoux et al. Frontiers in Oncology
- Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling
- (2015) Vincenzo Giambra et al. BLOOD
- Synergistic Leukemia Eradication by Combined Treatment with Retinoic Acid and HIF Inhibition by EZN-2208 (PEG-SN38) in Preclinical Models of PML-RAR and PLZF-RAR -Driven Leukemia
- (2015) N. Coltella et al. CLINICAL CANCER RESEARCH
- Concise Review: The Role of Oxygen in Hematopoietic Stem Cell Physiology
- (2015) Mojca Jež et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance
- (2015) Milica Vukovic et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML
- (2015) C E Forristal et al. LEUKEMIA
- AML1/ETO cooperates with HIF1α to promote leukemogenesis through DNMT3a transactivation
- (2015) X N Gao et al. LEUKEMIA
- Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists
- (2015) Stéphane Prost et al. NATURE
- Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells
- (2015) Micol Rigoni et al. Oncotarget
- HIF-1 can act as a tumor suppressor gene in murine acute myeloid leukemia
- (2014) T. Velasco-Hernandez et al. BLOOD
- Direct measurement of local oxygen concentration in the bone marrow of live animals
- (2014) Joel A. Spencer et al. NATURE
- Phase 1 evaluation of EZN-2208, a polyethylene glycol conjugate of SN38, in children adolescents and young adults with relapsed or refractory solid tumors
- (2014) Robin E. Norris et al. PEDIATRIC BLOOD & CANCER
- Bone Marrow Endosteal Mesenchymal Progenitors Depend on HIF Factors for Maintenance and Regulation of Hematopoiesis
- (2014) Jlenia Guarnerio et al. Stem Cell Reports
- Hif-2 is not essential for cell-autonomous hematopoietic stem cell maintenance
- (2013) A. V. Guitart et al. BLOOD
- Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells
- (2013) F. Lassailly et al. BLOOD
- HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress
- (2013) R. P. Singh et al. BLOOD
- HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress
- (2013) Kevin Rouault-Pierre et al. Cell Stem Cell
- Transcriptional regulation by hypoxia inducible factors
- (2013) Veronica L. Dengler et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
- (2013) Gregg L. Semenza JOURNAL OF CLINICAL INVESTIGATION
- Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells
- (2013) Jie Zou et al. Journal of Hematology & Oncology
- Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor
- (2013) Jamie L. Rogers et al. JOURNAL OF MEDICINAL CHEMISTRY
- Allosteric inhibition of hypoxia inducible factor-2 with small molecules
- (2013) Thomas H Scheuermann et al. Nature Chemical Biology
- Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells
- (2012) F. Kocabas et al. BLOOD
- HIF1 is required for survival maintenance of chronic myeloid leukemia stem cells
- (2012) H. Zhang et al. BLOOD
- Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment
- (2012) Olga Frolova et al. CANCER BIOLOGY & THERAPY
- HIF-1α protein is upregulated in HIF-2α depleted cells via enhanced translation
- (2012) Kathrin Schulz et al. FEBS LETTERS
- Elevated HIF-1α expression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy
- (2012) T. Matsunaga et al. LEUKEMIA RESEARCH
- IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
- (2012) Masato Sasaki et al. NATURE
- The VHL/HIF axis in clear cell renal carcinoma
- (2012) Chuan Shen et al. SEMINARS IN CANCER BIOLOGY
- Passing the baton: the HIF switch
- (2012) Mei Yee Koh et al. TRENDS IN BIOCHEMICAL SCIENCES
- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
- (2011) J. Schodel et al. BLOOD
- Identification of HIF2 as an important STAT5 target gene in human hematopoietic stem cells
- (2011) S. Fatrai et al. BLOOD
- Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies
- (2011) Yin Wang et al. Cell Stem Cell
- The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche
- (2010) Tugba Simsek et al. Cell Stem Cell
- Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells
- (2010) Keiyo Takubo et al. Cell Stem Cell
- Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming
- (2010) F Zhao et al. ONCOGENE
- Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans
- (2010) Cormac T. Taylor et al. PHYSIOLOGY
- Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells
- (2009) A. K. Ghosh et al. BLOOD
- Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
- (2009) David R. Mole et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oxygen homeostasis
- (2009) Gregg L. Semenza Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
- (2008) William G. Kaelin et al. MOLECULAR CELL
- Digoxin and other cardiac glycosides inhibit HIF-1 synthesis and block tumor growth
- (2008) H. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started