Yeast: bridging the gap between phenotypic and biochemical assays for high-throughput screening

Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan

(2018) Elizabeth Bilsland et al.   Scientific Reports

Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

(2018) Jennifer L. Norcliffe et al.   Scientific Reports

Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites

(2017) John G. Mina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New active leads for tuberculosis booster drugs by structure-based drug discovery

(2017) Natalie J. Tatum et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design

(2017) EMILY M. CARDEW et al.   PARASITOLOGY

Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis

(2017) JOHN G. M. MINA et al.   PARASITOLOGY

Fragment-based approaches to TB drugs

(2016) CHIARA MARCHETTI et al.   PARASITOLOGY

Yeast-Based High-Throughput Screens to Identify Novel Compounds Active against Brugia malayi

(2016) Elizabeth Bilsland et al.   PLoS Neglected Tropical Diseases

Yeast-Based High-Throughput Screen Identifies Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitors That Kill Malaria Parasites

(2015) I. J. Frame et al.   ACS Chemical Biology

The utility of yeast as a tool for cell-based, target-directed high-throughput screening

(2013) J. L. NORCLIFFE et al.   PARASITOLOGY

A Yeast-Based Chemical Screen Identifies a PDE Inhibitor That Elevates Steroidogenesis in Mouse Leydig Cells via PDE8 and PDE4 Inhibition

(2013) Didem Demirbas et al.   PLoS One

Yeast-based automated high-throughput screens to identify anti-parasitic lead compounds

(2013) E. Bilsland et al.   Open Biology

Identification of Biologically Active PDE11-Selective Inhibitors Using a Yeast-Based High-Throughput Screen

(2012) Ozge Ceyhan et al.   CHEMISTRY & BIOLOGY

Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii

(2012) Steven Pratt et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Identification of antituberculosis agents that target ribosomal protein interactions using a yeast two-hybrid system

(2012) Y. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional genetics in Apicomplexa: Potentials and limits

(2011) Julien Limenitakis et al.   FEBS LETTERS

A yeast-based assay identifies drugs active against human mitochondrial disorders

(2011) E. Couplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast two-hybrid methods and their applications in drug discovery

(2011) Amel Hamdi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Functional Expression of Parasite Drug Targets and Their Human Orthologs in Yeast

(2011) Elizabeth Bilsland et al.   PLoS Neglected Tropical Diseases

Recent Progress in Phosphoinositide 3-Kinases: Oncogenic Properties and Prognostic and Therapeutic Implications

(2010) Guojun Wu   CURRENT PROTEIN & PEPTIDE SCIENCE

Cell-Based Assays for High-Throughput Screening

(2010) W. Frank An et al.   MOLECULAR BIOTECHNOLOGY

Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity

(2010) J. Marjanovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

(2009) L. J. Su et al.   Disease Models & Mechanisms

The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target

(2009) John G. Mina et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Rapid selection of cyclic peptides that reduce α-synuclein toxicity in yeast and animal models

(2009) Joshua A Kritzer et al.   Nature Chemical Biology