A vaccine against Alzheimer`s disease: anything left but faith?

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Stimulus package

(2018)   NATURE MEDICINE

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

(2018) Maria Luisa Moro et al.   Acta Neuropathologica Communications

Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer’s Disease

(2017) Irina Petrushina et al.   MOLECULAR THERAPY

Plant-based chimeric HPV-virus-like particles bearing amyloid-β epitopes elicit antibodies able to recognize amyloid plaques in APP-tg mouse and Alzheimer’s disease brains

(2017) R. Gonzalez-Castro et al.   INFLAMMOPHARMACOLOGY

Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer’s and cat allergy

(2017) Andris Zeltins et al.   npj Vaccines

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Active immunization with the peptide epitope vaccine Aβ3-10-KLH induces a Th2-polarized anti-Aβ antibody response and decreases amyloid plaques in APP/PS1 transgenic mice

(2016) Li Ding et al.   NEUROSCIENCE LETTERS

Recent global trends in the prevalence and incidence of dementia, and survival with dementia

(2016) Martin Prince et al.   Alzheimers Research & Therapy

Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects?

(2014) Paul Carrillo-Mora et al.   Oxidative Medicine and Cellular Longevity

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

Vaccination against Alzheimer disease

(2014) Antonia Fettelschoss et al.   Human Vaccines & Immunotherapeutics

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Treating Alzheimer’s disease with monoclonal antibodies: current status and outlook for the future

(2013) Niels D Prins et al.   Alzheimers Research & Therapy

Tau Oligomers as Potential Targets for Alzheimer’s Diagnosis and Novel Drugs

(2013) Leonardo Guzmán-Martinez et al.   Frontiers in Neurology

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

(2012) Bengt Winblad et al.   LANCET NEUROLOGY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab

(2011) Susanne Ostrowitzki   ARCHIVES OF NEUROLOGY

Virus-like particle based vaccines for Alzheimer disease

(2011) Bryce Chackerian   Human vaccines & immunotherapeutics

Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease

(2011) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Second-Generation Active A  Immunotherapy CAD106 Reduces Amyloid Accumulation in APP Transgenic Mice While Minimizing Potential Side Effects

(2011) C. Wiessner et al.   JOURNAL OF NEUROSCIENCE

Cutting Edge: IL-21 and TLR Signaling Regulate Germinal Center Responses in a B Cell-Intrinsic Manner

(2010) J. Bessa et al.   JOURNAL OF IMMUNOLOGY

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

(2010) Juha O Rinne et al.   LANCET NEUROLOGY

Dementia incidence continues to increase with age in the oldest old: The 90+ study

(2009) María M. Corrada et al.   ANNALS OF NEUROLOGY

Alveolar Macrophages and Lung Dendritic Cells Sense RNA and Drive Mucosal IgA Responses

(2009) J. Bessa et al.   JOURNAL OF IMMUNOLOGY

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

(2009) Oliver Wirths et al.   JOURNAL OF NEURAL TRANSMISSION

The Cost of Dementia in Europe

(2009) Linus Jönsson et al.   PHARMACOECONOMICS