Dysregulated Translation in Neurodevelopmental Disorders: An Overview of Autism-Risk Genes Involved in Translation

Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies

(2018) Anwesha Banerjee et al.   BRAIN RESEARCH

Decoding hidden messages in neurons: insights from epitranscriptome-controlled and specialized ribosome-controlled translation

(2018) Yi-Shuian Huang et al.   CURRENT OPINION IN NEUROBIOLOGY

New frontiers in RNA transport and local translation in neurons

(2018) Sarah J. Van Driesche et al.   Developmental Neurobiology

Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG

(2018) Yuki Ogawa et al.   NEUROSCIENCE RESEARCH

4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2

(2018) Cinthia C Amaya Ramirez et al.   NUCLEIC ACIDS RESEARCH

Elavl3 is essential for the maintenance of Purkinje neuron axons

(2018) Yuki Ogawa et al.   Scientific Reports

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing

(2018) Alberto Parras et al.   NATURE

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression

(2017) Daniel Peter et al.   GENES & DEVELOPMENT

Regulation of m 6 A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline

(2017) Magdalena Natalia Wojtas et al.   MOLECULAR CELL

Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide

(2017) Zhen Shi et al.   MOLECULAR CELL

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

(2017) Ilse Gantois et al.   NATURE MEDICINE

Rps26 directs mRNA-specific translation by recognition of Kozak sequence elements

(2017) Max B Ferretti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

(2017) Emanuela Santini et al.   Science Signaling

Rps26 directs mRNA-specific translation by recognition of Kozak sequence elements

(2017) Max B Ferretti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Olfactory-Experience- and Developmental-Stage-Dependent Control of CPEB4 Regulates c- Fos mRNA Translation for Granule Cell Survival

(2017) Ching-San Tseng et al.   Cell Reports

RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation

(2017) Kei Nakayama et al.   eLife

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

(2017) Emanuela Santini et al.   Science Signaling

Fragile X syndrome

(2017) Randi J. Hagerman et al.   Nature Reviews Disease Primers

Dynamic mRNA Transport and Local Translation in Radial Glial Progenitors of the Developing Brain

(2016) Louis-Jan Pilaz et al.   CURRENT BIOLOGY

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

A Point Mutation in the Exon Junction Complex Factor Y14 Disrupts Its Function in mRNA Cap Binding and Translation Enhancement

(2016) Tzu-Wei Chuang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of mRNA Localization and Translation in Genetic Disease

(2016) Eric T. Wang et al.   JOURNAL OF NEUROSCIENCE

eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition

(2016) Angelita Simonetti et al.   MOLECULAR CELL

Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder

(2016) Ye E Wu et al.   NATURE NEUROSCIENCE

De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia

(2016) Atsushi Takata et al.   NEURON

Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes

(2016) Ji-Ann Lee et al.   NEURON

Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials

(2016) Elizabeth Berry-Kravis et al.   Science Translational Medicine

Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty

(2016) Rie Ohashi et al.   Scientific Reports

Translating the Genome in Time and Space: Specialized Ribosomes, RNA Regulons, and RNA-Binding Proteins

(2015) Zhen Shi et al.   Annual Review of Cell and Developmental Biology

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

Rbm8a Haploinsufficiency Disrupts Embryonic Cortical Development Resulting in Microcephaly

(2015) H. Mao et al.   JOURNAL OF NEUROSCIENCE

Structure of the human 80S ribosome

(2015) Heena Khatter et al.   NATURE

Structure of mammalian eIF3 in the context of the 43S preinitiation complex

(2015) Amedee des Georges et al.   NATURE

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Dysregulation and restoration of translational homeostasis in fragile X syndrome

(2015) Joel D. Richter et al.   NATURE REVIEWS NEUROSCIENCE

From the genetic architecture to synaptic plasticity in autism spectrum disorder

(2015) Thomas Bourgeron   NATURE REVIEWS NEUROSCIENCE

JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse

(2015) Jamee M. Berg et al.   NEURON

Reduced protein synthesis in schizophrenia patient-derived olfactory cells

(2015) J A English et al.   Translational Psychiatry

Dendritic targeting of short and long 3′ UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins

(2015) Annalisa Vicario et al.   Frontiers in Molecular Neuroscience

Brain-specific transcriptional regulator T-brain-1 controls brain wiring and neuronal activity in autism spectrum disorders

(2015) Tzyy-Nan Huang et al.   Frontiers in Neuroscience

SnapShot: FMRP mRNA Targets and Diseases

(2014) Emanuela Pasciuto et al.   CELL

Remote Control of Gene Function by Local Translation

(2014) Hosung Jung et al.   CELL

De novo EEF1A2mutations in patients with characteristic facial features, intellectual disability, autistic behaviors and epilepsy

(2014) J. Nakajima et al.   CLINICAL GENETICS

Prioritization of neurodevelopmental disease genes by discovery of new mutations

(2014) Alexander Hoischen et al.   NATURE NEUROSCIENCE

FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry

(2014) Giorgio La Fata et al.   NATURE NEUROSCIENCE

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammalian translation elongation factor eEF1A2: X-ray structure and new features of GDP/GTP exchange mechanism in higher eukaryotes

(2014) Thibaut Crepin et al.   NUCLEIC ACIDS RESEARCH

Serum microRNA profiles in children with autism

(2014) Mahesh Mundalil Vasu et al.   Molecular Autism

Common microRNAs Target Established ASD Genes

(2014) Sharmila Banerjee-Basu et al.   Frontiers in Neurology

Role of Sam68 in Post-Transcriptional Gene Regulation

(2013) Flora Sánchez-Jiménez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Disruption of Celf6, a Gene Identified by Translational Profiling of Serotonergic Neurons, Results in Autism-Related Behaviors

(2013) J. D. Dougherty et al.   JOURNAL OF NEUROSCIENCE

ELAV proteins along evolution: Back to the nucleus?

(2013) Claudia Colombrita et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology

(2013) Tsuyoshi Udagawa et al.   NATURE MEDICINE

Diversifying microRNA sequence and function

(2013) Stefan L. Ameres et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome

(2013) Emily K. Osterweil et al.   NEURON

Eukaryotic rpL10 drives ribosomal rotation

(2013) Sergey O. Sulima et al.   NUCLEIC ACIDS RESEARCH

Aberrant sodium channel activity in the complex seizure disorder ofCelf4mutant mice

(2012) Wenzhi Sun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Enhanced Susceptibility of Ago1/3 Double-Null Mice to Influenza A Virus Infection

(2012) Melanie Van Stry et al.   JOURNAL OF VIROLOGY

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

Autism-related deficits via dysregulated eIF4E-dependent translational control

(2012) Christos G. Gkogkas et al.   NATURE

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

(2012) Emanuela Santini et al.   NATURE

The translin–TRAX complex (C3PO) is a ribonuclease in tRNA processing

(2012) Liande Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

(2012) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neuronal Elav-like (Hu) Proteins Regulate RNA Splicing and Abundance to Control Glutamate Levels and Neuronal Excitability

(2012) Gulayse Ince-Dunn et al.   NEURON

Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability

(2012) Joep de Ligt et al.   NEW ENGLAND JOURNAL OF MEDICINE

BC1-FMRP interaction is modulated by 2′-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses

(2012) Caroline Lacoux et al.   NUCLEIC ACIDS RESEARCH

Fragile Mental Retardation Protein Interacts with the RNA-Binding Protein Caprin1 in Neuronal RiboNucleoProtein Complexes

(2012) Rachid El Fatimy et al.   PLoS One

CELF4 Regulates Translation and Local Abundance of a Vast Set of mRNAs, Including Genes Associated with Regulation of Synaptic Function

(2012) Jacy L. Wagnon et al.   PLoS Genetics

Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder

(2011) A. Chiocchetti et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

(2011) Michael R. Santoro et al.   Annual Review of Pathology-Mechanisms of Disease

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

(2011) Benedetta Ruzzenente et al.   EMBO JOURNAL

Mechanisms of dendritic mRNA transport and its role in synaptic tagging

(2011) Michael Doyle et al.   EMBO JOURNAL

Obesity resistance and increased hepatic expression of catabolism-related mRNAs inCnot3+/−mice

(2011) Masahiro Morita et al.   EMBO JOURNAL

CPEB2-eEF2 interaction impedes HIF-1α RNA translation

(2011) Po-Jen Chen et al.   EMBO JOURNAL

Local RNA Translation at the Synapse and in Disease

(2011) L. Liu-Yesucevitz et al.   JOURNAL OF NEUROSCIENCE

Identification of an mRNP Complex Regulating Tumorigenesis at the Translational Elongation Step

(2011) George S. Hussey et al.   MOLECULAR CELL

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain

(2011) Lauren T Gehman et al.   NATURE GENETICS

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Structure of C3PO and mechanism of human RISC activation

(2011) Xuecheng Ye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly

(2011) Anna Herrmannová et al.   NUCLEIC ACIDS RESEARCH

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders

(2010) John L.R. Rubenstein   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms

(2010) Yen-Ching Wu et al.   JOURNAL OF NEUROCHEMISTRY

The RNA Recognition Motif of Eukaryotic Translation Initiation Factor 3g (eIF3g) Is Required for Resumption of Scanning of Posttermination Ribosomes for Reinitiation on GCN4 and Together with eIF3i Stimulates Linear Scanning

(2010) L. Cuchalova et al.   MOLECULAR AND CELLULAR BIOLOGY

A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders

(2010) A M Addington et al.   MOLECULAR PSYCHIATRY

Exon junction complex enhances translation of spliced mRNAs at multiple steps

(2009) Hyung Chul Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling

(2009) B. Giovannone et al.   HUMAN MOLECULAR GENETICS

Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism

(2009) F Laumonnier et al.   MOLECULAR PSYCHIATRY

The trip of the tip: understanding the growth cone machinery

(2009) Laura Anne Lowery et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

C3PO, an Endoribonuclease That Promotes RNAi by Facilitating RISC Activation

(2009) Y. Liu et al.   SCIENCE

The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP

(2008) Ilaria Napoli et al.   CELL

L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth

(2008) Ralf S Schmid et al.   CURRENT OPINION IN NEUROBIOLOGY

Translational control of localized mRNAs: restricting protein synthesis in space and time

(2008) Florence Besse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY