Epithelial-mesenchymal Transition and Cancer Stem Cells: At the Crossroads of Differentiation and Dedifferentiation

Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation

(2018) Xiangrui Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Revisiting epithelial-mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness

(2017) Tsai-Tsen Liao et al.   Molecular Oncology

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes

(2017) Qiuhong Li et al.   Nature Communications

EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids

(2017) Elvira Forte et al.   Cancers

Sequential EMT-MET induces neuronal conversion through Sox2

(2017) Songwei He et al.   Cell Discovery

SALL4, the missing link between stem cells, development and cancer

(2016) Hiro Tatetsu et al.   GENE

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(2016) Evelyne Beerling et al.   Cell Reports

New Insights into the Crossroads between EMT and Stemness in the Context of Cancer

(2016) Isabel Fabregat et al.   Journal of Clinical Medicine

High-throughput mRNA and miRNA profiling of epithelial-mesenchymal transition in MDCK cells

(2015) Priyank Shukla et al.   BMC GENOMICS

ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

(2015) Peijing Zhang et al.   CELL CYCLE

Pentimento: Neural Crest and the origin of mesectoderm

(2015) James A. Weston et al.   DEVELOPMENTAL BIOLOGY

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival

(2015) Anne Grosse-Wilde et al.   PLoS One

Snai1 Promotes ESC Exit from the Pluripotency by Direct Repression of Self-Renewal Genes

(2015) Federico Galvagni et al.   STEM CELLS

Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

(2015) Mohit Kumar Jolly et al.   Oncotarget

Twist Modulates Breast Cancer Stem Cells by Transcriptional Regulation of CD24 Expression

(2015) Farhad Vesuna et al.   NEOPLASIA

Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

(2014) T. Z. Tan et al.   EMBO Molecular Medicine

Cadherin switching during the formation and differentiation of the Drosophila mesoderm - implications for epithelial-to-mesenchymal transitions

(2014) G. Schafer et al.   JOURNAL OF CELL SCIENCE

Towards elucidating the connection between epithelial-mesenchymal transitions and stemness

(2014) M. K. Jolly et al.   Journal of the Royal Society Interface

MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells

(2014) Wei-Lun Hwang et al.   NATURE CELL BIOLOGY

Meteorin Regulates Mesendoderm Development by Enhancing Nodal Expression

(2014) Yoon-Young Kim et al.   PLoS One

Signaling mechanisms of the epithelial-mesenchymal transition

(2014) D. M. Gonzalez et al.   Science Signaling

Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment

(2014) Yongshun Lin et al.   Nature Communications

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming

(2014) Juli J. Unternaehrer et al.   Stem Cell Reports

FOXC2 Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Breast Cancer

(2013) B. G. Hollier et al.   CANCER RESEARCH

Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer

(2013) Tuan Zea Tan et al.   EMBO Molecular Medicine

Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT–MET mechanism for optimal reprogramming

(2013) Xiaopeng Liu et al.   NATURE CELL BIOLOGY

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition

(2013) Marcin Cieślik et al.   Epigenetics & Chromatin

Global Decrease of Histone H3K27 Acetylation in ZEB1-Induced Epithelial to Mesenchymal Transition in Lung Cancer Cells

(2013) Joëlle Roche et al.   Cancers

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Snail is an independent prognostic predictor for progression and patient survival of gastric cancer

(2012) Hongyong He et al.   CANCER SCIENCE

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

Epithelial-mesenchymal transitions: insights from development

(2012) J. Lim et al.   DEVELOPMENT

Neural crest and somitic mesoderm as paradigms to investigate cell fate decisions during development

(2012) Erez Nitzan et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis

(2012) A. R. Colas et al.   GENES & DEVELOPMENT

RAC1 activation mediates Twist1-induced cancer cell migration

(2012) Wen-Hao Yang et al.   NATURE CELL BIOLOGY

Snail1 controls TGF-β responsiveness and differentiation of mesenchymal stem cells

(2012) R Batlle et al.   ONCOGENE

Genomic DNA Copy-Number Alterations of the let-7 Family in Human Cancers

(2012) Yanling Wang et al.   PLoS One

Overexpression of Snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells

(2012) Fan Fan et al.   Cancer Medicine

Target cell movement in tumor and cardiovascular diseases based on the epithelial–mesenchymal transition concept

(2011) Kian-Ngiap Chua et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative

(2011) A. Biddle et al.   CANCER RESEARCH

A Wt1-Controlled Chromatin Switching Mechanism Underpins Tissue-Specific Wnt4 Activation and Repression

(2011) Abdelkader Essafi et al.   DEVELOPMENTAL CELL

SNAIL Regulates Interleukin-8 Expression, Stem Cell–Like Activity, and Tumorigenicity of Human Colorectal Carcinoma Cells

(2011) Wei–Lun Hwang et al.   GASTROENTEROLOGY

The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation

(2011) Ita Costello et al.   NATURE CELL BIOLOGY

Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells

(2011) Derk ten Berge et al.   NATURE CELL BIOLOGY

miR-34 miRNAs provide a barrier for somatic cell reprogramming

(2011) Yong Jin Choi et al.   NATURE CELL BIOLOGY

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition

(2011) Oliver G McDonald et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of Epithelial and Mesenchymal Markers in Ovarian Cancer Reveals Phenotypic Heterogeneity and Plasticity

(2011) Robert Strauss et al.   PLoS One

Double-Negative Feedback Loop between Reprogramming Factor LIN28 and microRNA let-7 Regulates Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells

(2010) X. Yang et al.   CANCER RESEARCH

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

(2010) Douglas S. Micalizzi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Opposing microRNA families regulate self-renewal in mouse embryonic stem cells

(2010) Collin Melton et al.   NATURE

Epithelial to Mesenchymal Transition Is Mechanistically Linked with Stem Cell Signatures in Prostate Cancer Cells

(2010) Dejuan Kong et al.   PLoS One

Epithelial-Mesenchymal Transition-Derived Cells Exhibit Multilineage Differentiation Potential Similar to Mesenchymal Stem Cells

(2010) Venkata Lokesh Battula et al.   STEM CELLS

Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma

(2009) A. J. O'Hara et al.   BLOOD

Expression analysis of E-cadherin, Slug and GSK3β in invasive ductal carcinoma of breast

(2009) Chandra P Prasad et al.   BMC CANCER

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

(2009) Z. Wang et al.   CANCER RESEARCH

Immune-Induced Epithelial to Mesenchymal Transition In vivo Generates Breast Cancer Stem Cells

(2009) M. Santisteban et al.   CANCER RESEARCH

Twist-1 Is a PPARδ-Inducible, Negative-Feedback Regulator of PGC-1α in Brown Fat Metabolism

(2009) Dongning Pan et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Stem Cell States, Fates, and the Rules of Attraction

(2009) Tariq Enver et al.   Cell Stem Cell

Tgfβ Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc

(2009) Nimet Maherali et al.   CURRENT BIOLOGY

The role of let-7 in cell differentiation and cancer

(2009) Benjamin Boyerinas et al.   ENDOCRINE-RELATED CANCER

Ovarian carcinoma pathology and genetics: recent advances

(2009) C. Blake Gilks et al.   HUMAN PATHOLOGY

Glomerular parietal epithelial cells of adult murine kidney undergo EMT to generate cells with traits of renal progenitors

(2009) Swetha G. et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

SNAI1 and SNAI2 Are Asymmetrically Expressed at the 2-Cell Stage and Become Segregated to the TE in the Mouse Blastocyst

(2009) Christine E. Bell et al.   PLoS One

A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans

(2009) C. M. Hammell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TWIST Family of Basic Helix-Loop-Helix Transcription Factors Mediate Human Mesenchymal Stem Cell Growth and Commitment

(2009) Sandra Isenmann et al.   STEM CELLS

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Periodic Activation of Wnt/β-Catenin Signaling Enhances Somatic Cell Reprogramming Mediated by Cell Fusion

(2008) Frederic Lluis et al.   Cell Stem Cell

Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency

(2008) Alexander Marson et al.   Cell Stem Cell

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

(2008) Derk ten Berge et al.   Cell Stem Cell

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE

Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation

(2008) Yangming Wang et al.   NATURE GENETICS

MicroRNA Expression and Identification of Putative miRNA Targets in Ovarian Cancer

(2008) Neetu Dahiya et al.   PLoS One

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One

Dissecting early regulatory relationships in the lamprey neural crest gene network

(2008) N. Nikitina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE

Transitions between epithelial and mesenchymal states in development and disease

(2008) Buzz Baum et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Twist-2 Controls Myeloid Lineage Development and Function

(2008) Andrew B Sharabi et al.   PLOS BIOLOGY

Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer

(2007) Farhad Vesuna et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS