The success and the challenge of all-trans retinoic acid in the treatment of cancer

Dasatinib synergizes with ATRA to trigger granulocytic differentiation in ATRA resistant acute promyelocytic leukemia cell lines via Lyn inhibition-mediated activation of RAF-1/MEK/ERK

(2017) Ming Ding et al.   FOOD AND CHEMICAL TOXICOLOGY

Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives

(2017) Derek McCulloch et al.   OncoTargets and Therapy

Optimizing Therapy for Acute Myeloid Leukemia

(2017) Holbrook E. Kohrt et al.   Journal of the National Comprehensive Cancer Network

All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo

(2016) H. S. Ma et al.   BLOOD

Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia

(2016) Héléna Boutzen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RAF-1/MEK/ERK pathway regulates ATRA-induced differentiation in acute promyelocytic leukemia cells through C/EBPβ, C/EBPε and PU.1

(2016) Xiang-qin Weng et al.   LEUKEMIA RESEARCH

The HER2 inhibitor TAK165 Sensitizes Human Acute Myeloid Leukemia Cells to Retinoic Acid-Induced Myeloid Differentiation by activating MEK/ERK mediated RARα/STAT1 axis

(2016) Xuejing Shao et al.   Scientific Reports

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells

(2015) M. P. Martelli et al.   BLOOD

Primary acute myeloid leukemia cells with overexpression of EVI-1 are sensitive to all-trans retinoic acid

(2015) H. J. M. P. Verhagen et al.   BLOOD

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

(2015) H. El Hajj et al.   BLOOD

DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients >60 years with acute myeloid leukemia who are ineligible for induction chemotherapy

(2015) Olga Grishina et al.   BMC CANCER

Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RAR  expression

(2015) F. Centritto et al.   EMBO Molecular Medicine

Epigenetic priming of non-small cell lung cancer cell lines to the antiproliferative and differentiating effects of all-trans retinoic acid

(2015) Gabriele Greve et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients

(2014) M. Tassara et al.   BLOOD

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia

(2014) Julien Ablain et al.   INTERNATIONAL JOURNAL OF CANCER

Matrine Cooperates with All-Trans Retinoic Acid on Differentiation Induction of All-Trans Retinoic Acid-Resistant Acute Promyelocytic Leukemia Cells (NB4-LR1): Possible Mechanisms

(2014) Dijiong Wu et al.   PLANTA MEDICA

Combined staurosporine and retinoic acid induces differentiation in retinoic acid resistant acute promyelocytic leukemia cell lines

(2014) Dong-zheng Ge et al.   Scientific Reports

Treating acute myeloid leukemia in older adults

(2014) E. S. Wang   Hematology-American Society of Hematology Education Program

Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway in Cancer Prevention and Treatment

(2013) R. M. Connolly et al.   CLINICAL CANCER RESEARCH

Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) in acute promyelocytic leukemia

(2013) Akihiro Tomita et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

All-trans retinoic acid potentiates the chemotherapeutic effect of cisplatin by inducing differentiation of tumor initiating cells in liver cancer

(2013) Yang Zhang et al.   JOURNAL OF HEPATOLOGY

Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells

(2013) Alejandro García-Regalado et al.   Molecular Cancer

Treatment-influenced associations of PML-RAR  mutations, FLT3 mutations, and additional chromosome abnormalities in relapsed acute promyelocytic leukemia

(2012) R. E. Gallagher et al.   BLOOD

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Combination of Valproic Acid and ATRA Restores RARβ2 Expression and Induces Differentiation in Cervical Cancer through the PI3K/Akt Pathway

(2012) D. Feng et al.   CURRENT MOLECULAR MEDICINE

Effect of all-transretinoic acid (ATRA) on syndecan-1 expression and its chemoprotective effect in benzo(α)pyrene-induced lung cancer mice model

(2012) D. Ramya et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Inhibition of metastatic lung cancer in C57BL/6 mice by liposome encapsulated all trans retinoic acid (ATRA)

(2012) Siddikuzzaman et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cross Talk between Signaling and Vitamin A Transport by the Retinol-Binding Protein Receptor STRA6

(2012) D. C. Berry et al.   MOLECULAR AND CELLULAR BIOLOGY

Bortezomib Sensitizes Human Acute Myeloid Leukemia Cells to All-Trans-Retinoic Acid-Induced Differentiation by Modifying the RAR /STAT1 Axis

(2012) M. Ying et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

(2012) Tino Schenk et al.   NATURE MEDICINE

Interferon-γ enhances promyelocytic leukemia protein expression in acute promyelocytic cells and cooperates with all-trans-retinoic acid to induce maturation of NB4 and NB4-R1 cells

(2012) PENGCHENG HE et al.   Experimental and Therapeutic Medicine

Retinoids, Retinoic Acid Receptors, and Cancer

(2011) Xiao-Han Tang et al.   Annual Review of Pathology-Mechanisms of Disease

Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours

(2011) R Pili et al.   BRITISH JOURNAL OF CANCER

GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells

(2011) J Si et al.   LEUKEMIA

Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells

(2011) J Congleton et al.   LEUKEMIA

A retinoic acid receptor RARα pool present in membrane lipid rafts forms complexes with G protein αQ to activate p38MAPK

(2011) A Piskunov et al.   ONCOGENE

Altered nuclear cofactor switching in retinoic-resistant variants of the PML-RARα oncoprotein of acute promyelocytic leukemia

(2011) Mindy Farris et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A pilot phase II trial of all-trans retinoic acid (Vesanoid) and paclitaxel (Taxol) in patients with recurrent or metastatic breast cancer

(2010) Margarette Bryan et al.   INVESTIGATIONAL NEW DRUGS

Randomized Phase II Trial of All-Trans-Retinoic Acid With Chemotherapy Based on Paclitaxel and Cisplatin As First-Line Treatment in Patients With Advanced Non–Small-Cell Lung Cancer

(2010) Oscar Arrieta et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of all-Trans-retinoic acid-induced proteasome activation potentiates the differentiating effect of retinoid in acute myeloid leukemia cells

(2010) Yanfen Fang et al.   MOLECULAR CARCINOGENESIS

The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and CEBPA

(2009) A. K. Burnett et al.   BLOOD

ZNF423 Is Critically Required for Retinoic Acid-Induced Differentiation and Is a Marker of Neuroblastoma Outcome

(2009) Sidong Huang et al.   CANCER CELL

Small Ubiquitin-Like Modifier-2 Modification of Retinoic Acid Receptor-α Regulates Its Subcellular Localization and Transcriptional Activity

(2009) Li Zhu et al.   ENDOCRINOLOGY

Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells

(2009) F. GAO et al.   International Journal of Laboratory Hematology

Insoluble, Speckled Cytosolic Distribution of Retinoic Acid Receptor Alpha Protein as a Marker of Hepatic Stellate Cell Activation In Vitro

(2009) Yoshihiro Mezaki et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1

(2009) M Osanai et al.   ONCOGENE

Emerging treatment strategies for acute myeloid leukemia (AML) in the elderly

(2008) Andrea Kuendgen et al.   CANCER TREATMENT REVIEWS

Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B

(2008) R. F. Schlenk et al.   HAEMATOLOGICA

Randomized Phase III Trial Comparing Bexarotene (L1069-49)/Cisplatin/Vinorelbine With Cisplatin/Vinorelbine in Chemotherapy-Naïve Patients With Advanced or Metastatic Non–Small-Cell Lung Cancer: SPIRIT I

(2008) Rodryg Ramlau et al.   JOURNAL OF CLINICAL ONCOLOGY

A Genecentric Human Protein Atlas for Expression Profiles Based on Antibodies

(2008) Lisa Berglund et al.   MOLECULAR & CELLULAR PROTEOMICS

All-trans-retinoic acid stimulates translation and induces spine formation in hippocampal neurons through a membrane-associated RARα

(2007) Na Chen et al.   FASEB JOURNAL