Review
Chemistry, Medicinal
Chengyuan Liang, Guaiping Qiao, Yuzhi Liu, Lei Tian, Nan Hui, Juan Li, Yuling Ma, Han Li, Qianqian Zhao, Wenqiang Cao, Hong Liu, Xiaodong Ren
Summary: All-trans-retinoic acid (ATRA) is effective in preventing cancer and treating skin diseases and acute promyelocytic leukaemia (APL) by regulating differentiation-related gene transcription and autophagy through inhibiting mTOR. A total of 68 ATRA analogues show promising antitumour therapeutic potential for further development and research.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Glenn J. Hanna, Anne ONeill, Jennifer M. Cutler, Michelle Flynn, Tushara Vijaykumar, John R. Clark, Lori J. Wirth, Jochen H. Lorch, Jong C. Park, Jeffrey K. Mito, Jens G. Lohr, Jeffrey Kaufman, Nicole Spardy Burr, Leonard Zon, Robert Haddad
Summary: While the trial did not meet its prespecified response endpoint, ATRA showed low toxicity and potential for stabilizing disease growth in a significant proportion of R/M ACC patients. Patients with prior VEGFR therapy had a higher rate of stable disease on ATRA. Low MYB protein expression correlated with longer stability on ATRA treatment.
Article
Pharmacology & Pharmacy
Xiao Liu, Lili Zhang, Yueying Yang, Weiwei Yin, Yunhu Liu, Chunyi Luo, Ruizhe Zhang, Zhiguo Long, Yanyan Jiang, Bing Wang
Summary: Arsenic trioxide (ATO) has been clinically used as a reliable and effective frontline drug for the treatment of acute promyelocytic leukemia (APL). However, its administration regimen is limited due to fast clearance, short therapeutic window, and toxicity. This study developed transferrin-modified liposomes encapsulating AsIII to improve its therapeutic efficacy. The AsIII-loaded liposomes exhibited acid-sensitive release and specifically targeted APL cells, leading to apoptosis and cell differentiation. Combining transferrin-modified retinoic acid liposomes further enhanced the tumor inhibition effect. The results suggest that transferrin-modified AsIII liposomes could be a novel clinical strategy for APL treatment with reduced systemic toxicity and improved efficacy.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyeyoun Kim, See-Hyoung Park, Sae Woong Oh, Kitae Kwon, Se Jung Park, Eunbi Yu, Seyoung Yang, Jung Yoen Park, Seoyoung Choi, Seoyoun Yang, Su Bin Han, Minkyung Song, Jae Youl Cho, Jongsung Lee
Summary: Olfactory receptor OR7A17 plays a role in the ATRA-induced suppression of human keratinocyte proliferation, regulated through retinoic acid receptor signaling. Overexpression of OR7A17 can reverse the ATRA-induced attenuation of Ca2+ entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Jichao Li, Zeng Zhang, Xiaohan Huang
Summary: The study developed Tripterine and all-trans retinoic acid loaded lipid-polymer hybrid nanoparticles for enhanced antiarthritic efficacy in arthritis conditions. The nanoparticles exhibited strong inhibitory effects on inflammatory markers and showed significant improvement in reducing inflammation compared to individual drugs. The co-delivery of drugs in nanoparticulate form could abolish the adverse effects of free drugs, indicating a promising therapeutic strategy for arthritis treatment.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Biophysics
Weinan Li, Hexin Gong, Yuhan Fu, Jialin Sun, Yanhong Wang
Summary: Developing a pH-sensitive prodrug delivery system using nanoparticle carriers shows promising results in inhibiting breast cancer cell growth and releasing drugs at lower pH levels.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Oncology
Luca Guarrera, Mami Kurosaki, Silvio-Ken Garattini, Maurizio Gianni', Gianpiero Fasola, Luca Rossit, Michele Prisciandaro, Maria Di Bartolomeo, Marco Bolis, Paola Rizzo, Claudia Nastasi, Marika Foglia, Adriana Zanetti, Gabriela Paroni, Mineko Terao, Enrico Garattini
Summary: This study provides pre-clinical evidence supporting the use of All-Trans Retinoic-acid (ATRA) in the treatment of gastric cancer. It demonstrates that approximately half of the gastric cancer cell lines are sensitive to ATRA and identifies a gene model that predicts ATRA sensitivity in gastric cancer patients. The study also reveals the immune-modulatory effects of ATRA and suggests potential combination therapies for gastric cancer management.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Ophthalmology
Dillon M. Brown, Jianshi Yu, Praveen Kumar, Quinn M. Paulus, Michael A. Kowalski, Jay M. Patel, Maureen A. Kane, C. Ross Ethier, Machelle T. Pardue
Summary: This study investigates the effects of exogenous all-trans retinoic acid (atRA) on myopia development and scleral biomechanics in mice.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biology
Maximilian Lenz, Pia Kruse, Amelie Eichler, Jakob Straehle, Juergen Beck, Thomas Deller, Andreas Vlachos
Summary: A defining feature of the brain is its ability for synaptic contacts to adapt structurally and functionally, with atRA being identified as a potent mediator of synaptic plasticity in the adult human cortex. The coordinated structural and functional changes in excitatory synapses observed in cortical slices were accompanied by ultrastructural remodeling of the spine apparatus organelle and required mRNA translation for these synaptic adaptations. The absence of these changes in synaptopodin-deficient mice suggests the importance of this organelle in the process.
Article
Medicine, Research & Experimental
Asadollah Abbasi, Mohammadali Hosseinpourfeizi, Reza Safaralizadeh
Summary: The study suggests that miR-30a/autophagy signaling plays a critical role in regulating the chemoresistance of GC cells, which could be modulated by ATRA.
Article
Biophysics
Francesca Cuomo, Sara Ceglie, Maria Miguel, Bjorn Lindman, Francesco Lopez
Summary: This study investigated the ability of cationic and anionic liposomes to encapsulate, protect, and deliver ATRA in an in-vitro digestion process, showing that cationic vesicles are preferable for higher bioavailability of ATRA.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Oncology
Song Wang, Jingtao Liu, Hao Wu, Anna Jiang, Kun Zhao, Kun Yan, Wei Wu, Haibo Han, Yanhua Zhang, Wei Yang
Summary: The study revealed that ATRA improved the efficacy of RFA treatment for hepatocellular carcinoma by targeting tumor-initiating cells (TICs). This finding suggests the potential of ATRA as an alternative drug in developing better therapeutic strategies for use in combination with RFA.
CHINESE JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Dong-Hwan Kim, Joonbum Lee, Yeunsu Suh, Jae-Kyun Ko, Kichoon Lee
Summary: This study found that all-trans-retinoic acid (atRA) can induce the transdifferentiation of myoblasts into adipocytes by increasing the expression of Ppar gamma. This discovery provides a new nutrient for enhancing marbling in poultry.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nutrition & Dietetics
King Clyde B. Yabut, Nina Isoherranen
Summary: Cellular retinoic acid binding proteins (CRABP1 and CRABP2) have a high affinity for all-trans-retinoic acid (atRA), and bind to atRA-clearing enzymes and nuclear receptors. This study shows that CRABP1 and CRABP2 also impact atRA metabolism by CYP26A1, suggesting their critical role in modulating atRA concentrations.
Article
Agriculture, Dairy & Animal Science
Yixin Chen, Haimei Zhou, Huadong Wu, Wei Lu, Yuyong He
Summary: Proper development of the fetal lung is vital for the survival and healthy growth of pigs. This study found that supplementing pregnant sows with all-trans retinoic acid (ATRA) can alleviate respiratory distress in neonatal piglets with a Hoxa1 mutation. The results showed that ATRA treatment improved the development of alveoli and pulmonary microvessels in the piglets, and regulated the expression of several genes associated with lung development.
Article
Medicine, Research & Experimental
R. Evangeline Breeta, Perinba Danisha Jesubatham, V. M. Berlin Grace, S. Viswanathan, S. Srividya
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Genetics & Heredity
S. Viswanathan, V. M. Berlin Grace
Article
Immunology
Helen Hencida Thangamony, Ravindran Kumar, Chinnappan Palaniappan Thangavelu, Mani Mariappa, Berlin Grace Viswanathan Mariammal, Kootallur Narayanan Brahmadathan
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2018)
Article
Pharmacology & Pharmacy
S. Viswanathan, V. M. Berlin Grace, J. Perinba Danisha
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Esther Sathya Bama, V. M. Berlin Grace, Viswanathan Sundaram, Perinba Dansiha Jesubatham
Article
Cell Biology
Ragavi Ravichandran, S. Viswanathan, V. M. Berlin Grace, Lucia Bonati, Jini Narayanan
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2019)
Article
Immunology
V. M. Berlin Grace, S. Viswanathan, D. David Wilson, S. Jagadish Kumar, K. Sahana, E. F. Maria Arbin, Jini Narayanan
INFLAMMOPHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Raja David Isac Evangeline Breeta, Viswanathan Mariammal Berlin Grace, Devarajan David Wilson
Summary: The combination of Sorafenib with Methyl Palmitate significantly enhanced anti-cancer effects on Hep-G2 cell line and reduced in vivo toxicity when compared with Sorafenib alone treatment.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Biochemical Research Methods
Viswanathan Mariammal Berlin Grace, Devarajan David Wilson, Chandrasekharan Guruvayoorappan, Jesubatham Perinba Danisha, Lucia Bonati
Summary: The study demonstrated that the nanoparticle carrier cationic lipo-ATRA enhanced the release and uptake of ATRA in lung cancer cells, leading to a significant decrease in cell viability. This suggests that DOTAP lipo-ATRA is a promising carrier for delivering ATRA to solid cancer cells.
IET NANOBIOTECHNOLOGY
(2021)
Article
Cell Biology
V. M. Berlin Grace, S. Saranya, D. David Wilson
Summary: All Trans Retinoic Acid (ATRA) has shown the ability to inhibit metastatic tumor growth in the lung and liver by inducing RAR-beta protein expression, leading to a reduction in pathological changes in these organs. ATRA also reduces cholesterol and GGT levels in cancer-induced mice, suggesting its potential as a therapeutic agent for lung cancer.
JOURNAL OF HISTOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Viswanathan Mariammal Berlin Grace, Devarajan David Wilson, M. Divyadharshini, S. Viswanathan, Siddikuzzaman, Rengaswamy Gopal
Summary: In this study, silver nanoparticles were synthesized using a flower extract of Cassia auriculata L. and their anti-diabetic efficiency was studied in rats. The results showed that these nanoparticles significantly reduced blood glucose levels in diabetic rats and restored damaged cells. They also normalized lipid profiles, serum protein, liver glycogen, and liver and kidney functions. This suggests that the biosynthesized silver nanoparticles may be a potential alternative biopharmaceutical agent for the treatment of diabetes.
RECENT PATENTS ON NANOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
V. M. Berlin Grace, D. David Wilson, R. Anushya, Siddikuzzaman
Summary: This study demonstrates that all trans retinoic acid can alleviate inflammatory symptoms in benzo(a)pyrene-induced mice, reduce COX-2 gene expression, and prevent carcinogenesis.
Article
Biotechnology & Applied Microbiology
V. M. Berlin Grace, D. David Wilson, S. Saranya, Rohit Peardon
Summary: The study found that ATRA treatment can inhibit the formation of metastatic nodules in the lung, restore metabolic changes and normalize antioxidant levels, while adjusting lipid and cholesterol levels.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Elvis Samuel, D. David Wilson, Catherene Tomy, D. Jerome Inder Nallakannu, Siddikuzzaman, Aavany Balasubramanian, V. M. Berlin Grace
Summary: This research aims to evaluate the synergistic activity of sorafenib and Platycladus orientalis leaf extraction on cervical cancer cells. Different concentrations of sorafenib and ethanol extract of Platycladus orientalis leaves were tested for cytotoxicity efficiency on HeLa cells. Combination treatment of sorafenib and crude leaf extract effectively suppressed cervical cancer cell growth and inhibited cell proliferation-induced apoptosis.
BIOSCIENCE JOURNAL
(2023)
Article
Pharmacology & Pharmacy
V. M. Berlin Grace, V. Sandeep, S. Viswanathan, B. Esther Sathyabama
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
