Amyloid beta soluble forms and plasminogen activation system in Alzheimer’s disease: Consequences on extracellular maturation of brain-derived neurotrophic factor and therapeutic implications

Association between Plasma Levels of PAI-1, tPA/PAI-1 Molar Ratio, and Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes Mellitus

(2018) Jiaqi Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

A Small Molecule Inhibitor of Plasminogen Activator Inhibitor-1 Reduces Brain Amyloid-β Load and Improves Memory in an Animal Model of Alzheimer’s Disease

(2018) Hasina Akhter et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic Alterations in Mouse Models for Alzheimer Disease—A Special Focus on N-Truncated Abeta 4-42

(2018) Katharina Dietrich et al.   MOLECULES

BDNF, TNFα, HSP90, CFH, and IL-10 Serum Levels in Patients with Early or Late Onset Alzheimer's Disease or Mild Cognitive Impairment

(2018) Duygu Gezen-Ak et al.   JOURNAL OF ALZHEIMERS DISEASE

proBDNF Accelerates Brain Amyloid-β Deposition and Learning and Memory Impairment in APPswePS1dE9 Transgenic Mice

(2017) Jia Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Morphine Withdrawal Increases Brain-Derived Neurotrophic Factor Precursor

(2017) Alessia Bachis et al.   NEUROTOXICITY RESEARCH

Role of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in psychological stress and depression

(2017) Shih-Jen Tsai   Oncotarget

Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

(2017) David L. Brody et al.   Alzheimers Research & Therapy

The serum protein levels of the tPA–BDNF pathway are implicated in depression and antidepressant treatment

(2017) H Jiang et al.   Translational Psychiatry

The Tissue Plasminogen Activator/Plasmin System May Act Through Cleavage of Pro-BDNF to Increase Risk of Substance Abuse

(2017) Cheng-Dien Hsu et al.   CNS SPECTRUMS

Brain-Derived Neurotrophic Factor Levels in Alzheimer's Disease

(2017) Sid E. O'Bryant et al.   JOURNAL OF ALZHEIMERS DISEASE

Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders

(2017) Suzhen Chen et al.   Scientific Reports

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

(2016) Ting Yang et al.   JOURNAL OF NEUROSCIENCE

Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model

(2016) Bo Yeong Jeong et al.   PLoS One

Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity

(2016) Levi M. Smith et al.   Cold Spring Harbor Perspectives in Medicine

Impacts of aging and amyloid-β deposition on plasminogen activators and plasminogen activator inhibitor-1 in the Tg2576 mouse model of Alzheimer׳s disease

(2015) Shin Bi Oh et al.   BRAIN RESEARCH

Lower Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor Predicts Progression from Mild Cognitive Impairment to Alzheimer’s Disease

(2015) Orestes Vicente Forlenza et al.   NEUROMOLECULAR MEDICINE

Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis

(2015) Nicolas Pelisch et al.   PLoS One

Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus

(2015) Grzegorz Wiera et al.   Frontiers in Cellular Neuroscience

Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model

(2015) Laura Psotta et al.   Frontiers in Behavioral Neuroscience

Plasminogen activator inhibitor-1 as an early potential diagnostic marker for Alzheimer's disease

(2014) Jaeho Oh et al.   EXPERIMENTAL GERONTOLOGY

Brain-Derived Neurotrophic Factor Plasma Levels: Relationship With Dementia and Diabetes in the Elderly Population

(2014) Angela Passaro et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Exogenous t-PA Administration Increases Hippocampal Mature BDNF Levels. Plasmin- or NMDA-Dependent Mechanism?

(2014) Marion Rodier et al.   PLoS One

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

(2014) Jianmin Yang et al.   Cell Reports

A Large, Cross-Sectional Observational Study of Serum BDNF, Cognitive Function, and Mild Cognitive Impairment in the Elderly

(2014) Hiroyuki Shimada et al.   Frontiers in Aging Neuroscience

The stimulation of dendritic cells by amyloid beta 1–42 reduces BDNF production in Alzheimer’s disease patients

(2013) Antonio Ciaramella et al.   BRAIN BEHAVIOR AND IMMUNITY

Tissue plasminogen activator arrests Alzheimer's disease pathogenesis

(2013) Shin Bi Oh et al.   NEUROBIOLOGY OF AGING

Alzheimer's Disease Related Markers, Cellular Toxicity and Behavioral Deficits Induced Six Weeks after Oligomeric Amyloid-β Peptide Injection in Rats

(2013) Charleine Zussy et al.   PLoS One

Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

(2013) W. C. Wetsel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

(2013) Agustin Anastasia et al.   Nature Communications

Involvement of TrkB- and p75NTR-signaling pathways in two contrasting forms of long-lasting synaptic plasticity

(2013) Shigeo Sakuragi et al.   Scientific Reports

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Aβ Toxicity in Alzheimer's Disease

(2012) Virve Cavallucci et al.   MOLECULAR NEUROBIOLOGY

Review: Systemic inflammation and Alzheimer's disease

(2012) C. Holmes   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Quercetin protects against the Aβ25–35-induced amnesic injury: Involvement of inactivation of RAGE-mediated pathway and conservation of the NVU

(2012) Rui Liu et al.   NEUROPHARMACOLOGY

ProBDNF Collapses Neurite Outgrowth of Primary Neurons by Activating RhoA

(2012) Ying Sun et al.   PLoS One

Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses

(2012) H. S. Je et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Value of Small Molecule Inhibitor to Plasminogen Activator Inhibitor–1 for Lung Fibrosis

(2011) Wen-Tan Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Activators and inhibitors of the plasminogen system in Alzheimer’s disease

(2011) Rachel Barker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Plasminogen and plasmin in Alzheimer's disease

(2010) Rachel Barker et al.   BRAIN RESEARCH

Alzheimers Disease (AD) and Mild Cognitive Impairment (MCI) Patients are Characterized by Increased BDNF Serum Levels

(2010) F. Angelucci et al.   Current Alzheimer Research

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment

(2010) Orestes Vicente Forlenza et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Tissue-type plasminogen activator-plasmin-BDNF modulate glutamate-induced phase-shifts of the mouse suprachiasmatic circadian clockin vitro

(2009) Xiang Mou et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Plasminogen activator activity is inhibited while neuroserpin is up-regulated in the Alzheimer disease brain

(2009) Shay Fabbro et al.   JOURNAL OF NEUROCHEMISTRY

Brain-Derived Neurotrophic Factor Reduces Amyloidogenic Processing through Control of SORLA Gene Expression

(2009) M. Rohe et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

β-Amyloid impairs axonal BDNF retrograde trafficking

(2009) Wayne W. Poon et al.   NEUROBIOLOGY OF AGING

Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease

(2009) R.-M. Liu et al.   NEUROBIOLOGY OF AGING

Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor and Cognitive Function in Non-Demented Subjects

(2009) Ge Li et al.   PLoS One

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

Activation of pro-BDNF by the pericellular serine protease plasmin

(2008) Kelly Gray et al.   FEBS LETTERS

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

A Biological Function for the Neuronal Activity-Dependent Component of Bdnf Transcription in the Development of Cortical Inhibition

(2008) Elizabeth J. Hong et al.   NEURON

Enhanced clearance of A  in brain by sustaining the plasmin proteolysis cascade

(2008) J. S. Jacobsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic

(2008) Manuel Yepes et al.   TRENDS IN NEUROSCIENCES

Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice

(2007) Jian Ping Zhou et al.   BRAIN RESEARCH

BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

(2007) Yuan Lu et al.   NEUROBIOLOGY OF LEARNING AND MEMORY