Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

Implication of the proprotein convertases in iron homeostasis: Proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin

(2013) Johann Guillemot et al.   HEPATOLOGY

Internalization of Proprotein Convertase PC7 from Plasma Membrane Is Mediated by a Novel Motif

(2012) Jeroen Declercq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-dependent deficits in fear learning in heterozygous BDNF knock-out mice

(2012) T. Endres et al.   LEARNING & MEMORY

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

A Homolog of Subtilisin-Like Proprotein Convertase 7 Is Essential to Anterior Neural Development in Xenopus

(2012) Sema Senturker et al.   PLoS One

Proprotein Convertase PC7 Enhances the Activation of the EGF Receptor Pathway through Processing of the EGF Precursor

(2011) Estelle Rousselet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Precursor of Brain-derived Neurotrophic Factor (proBDNF) Forms a Complex with Huntingtin-associated Protein-1 (HAP1) and Sortilin That Modulates proBDNF Trafficking, Degradation, and Processing

(2011) Miao Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

(2011) Latha Devi et al.   NEUROPSYCHOPHARMACOLOGY

Effect of 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, on Emotional Learning

(2010) Raul Andero et al.   AMERICAN JOURNAL OF PSYCHIATRY

The Proprotein Convertase PC7

(2010) Estelle Rousselet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-Endoplasmic Reticulum Rescue of Unstable MHC Class I Requires Proprotein Convertase PC7

(2010) R. M. Leonhardt et al.   JOURNAL OF IMMUNOLOGY

Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear

(2010) D. C. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

(2010) S.-W. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear

(2009) B. Porton et al.   GENES BRAIN AND BEHAVIOR

Mechanisms, locations, and kinetics of synaptic BDNF secretion: An update

(2009) Volkmar Leßmann et al.   NEUROSCIENCE RESEARCH

Knock-out mouse models of proprotein convertases: unique functions or redundancy?

(2008) John et al.   Frontiers in Bioscience-Landmark

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

(2008) Tomoya Matsumoto et al.   NATURE NEUROSCIENCE

Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory

(2007) R. M. Rodriguiz et al.   GENES BRAIN AND BEHAVIOR