Role of periostin, FENO, IL-13, lebrikzumab, other IL-13 antagonist and dual IL-4/IL-13 antagonist in asthma

An IL-4/IL-13 Dual Antagonist Reduces Lung Inflammation, Airway Hyperresponsiveness, and IgE Production in Mice

(2013) Marion T. Kasaian et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids

(2013) Michael Noonan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficient cytokine-induced IL-13 production by mast cells requires both IL-33 and IL-3

(2013) Ilkka S. Junttila et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines

(2013) Christoph Spiess et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab

(2013) Mark Ultsch et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibiting Interleukin-4 and Interleukin-13 in Difficult-to-Control Asthma

(2013) Michael E. Wechsler   NEW ENGLAND JOURNAL OF MEDICINE

Severe asthma: future treatments

(2012) P. M. O'Byrne et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Pathogenesis of severe asthma

(2012) A. H. Poon et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma

(2012) Edward Piper et al.   EUROPEAN RESPIRATORY JOURNAL

Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts

(2012) Kanako Ontsuka et al.   EXPERIMENTAL DERMATOLOGY

IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti–IL-4 receptor α antagonist

(2012) Rebecca E. Slager et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

(2012) Guiquan Jia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-13 in asthma and allergic disease: Asthma phenotypes and targeted therapies

(2012) Jennifer L. Ingram et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Periostin promotes chronic allergic inflammation in response to Th2 cytokines

(2012) Miho Masuoka et al.   JOURNAL OF CLINICAL INVESTIGATION

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Matricellular Proteins in Cardiac Adaptation and Disease

(2012) Nikolaos G. Frangogiannis   PHYSIOLOGICAL REVIEWS

G Protein βγ-Subunit Signaling Mediates Airway Hyperresponsiveness and Inflammation in Allergic Asthma

(2012) Gustavo Nino et al.   PLoS One

Asthma

(2012) Peter Barnes et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FeNO) for Clinical Applications

(2011) Raed A. Dweik et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness

(2011) E. D. Gordon et al.   CLINICAL AND EXPERIMENTAL ALLERGY

IL-33-Responsive Lineage-CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs

(2011) K. R. Bartemes et al.   JOURNAL OF IMMUNOLOGY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Steroid-resistant asthma

(2011) Robert P. Yim et al.   Paediatric Respiratory Reviews

Delayed Re-Epithelialization in Periostin-Deficient Mice during Cutaneous Wound Healing

(2011) Takashi Nishiyama et al.   PLoS One

IL-4 and IL-13 Dual Antagonism

(2010) Larry Borish   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma

(2010) Jonathan Corren et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of interleukin 13 on bronchial hyperresponsiveness and the bronchoprotective effect of β-adrenergic bronchodilators and corticosteroids

(2010) Robert G. Townley et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Omalizumab for pediatric asthma

(2010) Robert G Townley et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Roles of epithelial cell-derived periostin in TGF-  activation, collagen production, and collagen gel elasticity in asthma

(2010) S. S. Sidhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal expression of periostin during skin development and incisional wound healing: lessons for human fibrotic scar formation

(2010) Hong-Ming Zhou et al.   Journal of Cell Communication and Signaling

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Origin of Cardiac Fibroblasts and the Role of Periostin

(2009) Paige Snider et al.   CIRCULATION RESEARCH

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells

(2008) K. Chibana et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Increased sputum and bronchial biopsy IL-13 expression in severe asthma

(2008) Shironjit K. Saha et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses

(2008) C Blanchard et al.   Mucosal Immunology