Stromal Fibroblast in Age-Related Cancer: Role in Tumorigenesis and Potential as Novel Therapeutic Target

Reversing the aging stromal phenotype prevents carcinoma initiation

(2016) Davina A. Lewis et al.   Aging-US

Rapamycin extends life- and health span because it slows aging

(2016) Mikhail V. Blagosklonny   Aging-US

Inflammaging decreases adaptive and innate immune responses in mice and humans

(2015) Daniela Frasca et al.   BIOGERONTOLOGY

Microenvironmental regulation of therapeutic response in cancer

(2015) Florian Klemm et al.   TRENDS IN CELL BIOLOGY

Interleukin 12: still a promising candidate for tumor immunotherapy?

(2014) Witold Lasek et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Differential TIMP3 expression affects tumor progression and angiogenesis in melanomas through regulation of directionally persistent endothelial cell migration

(2013) Asha M. Das et al.   ANGIOGENESIS

Caloric restriction and its mimetics

(2013) Shin-Hae Lee et al.   BMB Reports

Subtypes of cytotoxic lymphocytes and natural killer cells infiltrating cancer nests correlate with prognosis in patients with vulvar squamous cell carcinoma

(2013) Jacek Jan Sznurkowski et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

(2013) Javier A. Menendez et al.   CELL CYCLE

Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment

(2013) Ubaldo E Martinez-Outschoorn et al.   CELL CYCLE

Fibroblast activation protein-α promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms

(2013) WeiWei Yang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The immune system and aging: a review

(2013) Camil Castelo-Branco et al.   GYNECOLOGICAL ENDOCRINOLOGY

Tumor associated macrophages and neutrophils in cancer

(2013) Maria Rosaria Galdiero et al.   IMMUNOBIOLOGY

Dietary selenium supplementation modifies breast tumor growth and metastasis

(2013) Yu-Chi Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Phenotypic characterization of human prostatic stromal cells in primary cultures derived from human tissue samples

(2013) GIOVANNI LUCA GRAVINA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Collapse of the Tumor Stroma is Triggered by IL-12 Induction of Fas

(2013) Sid P Kerkar et al.   MOLECULAR THERAPY

Transmitting senescence to the cell neighbourhood

(2013) Matthew Hoare et al.   NATURE CELL BIOLOGY

Fibroblast Growth Factor 2 Causes G2/M Cell Cycle Arrest in Ras-Driven Tumor Cells through a Src-Dependent Pathway

(2013) Jacqueline Salotti et al.   PLoS One

The Tumor Microenvironment: A Pitch for Multiple Players

(2013) Giovanna Schiavoni et al.   Frontiers in Oncology

Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment

(2012) Isabelle Mercier et al.   AMERICAN JOURNAL OF PATHOLOGY

Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia

(2012) A. Wiestner   BLOOD

Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression

(2012) E. Pazolli et al.   CANCER RESEARCH

Effects of Aging on Angiogenesis

(2012) Johanna Lähteenvuo et al.   CIRCULATION RESEARCH

Therapeutic Targeting of Redox Signaling in Myofibroblast Differentiation and Age-Related Fibrotic Disease

(2012) Natalie Sampson et al.   Oxidative Medicine and Cellular Longevity

Insights into the beneficial effect of caloric/ dietary restriction for a healthy and prolonged life

(2012) Rani Pallavi et al.   Frontiers in Physiology

Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms

(2011) Federica Sotgia et al.   Annual Review of Pathology-Mechanisms of Disease

The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia

(2011) J. Hoellenriegel et al.   BLOOD

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Accelerated aging in the tumor microenvironment

(2011) Michael P Lisanti et al.   CELL CYCLE

Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth

(2011) Renee M. Balliet et al.   CELL CYCLE

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

(2011) Michael P Lisanti et al.   CELL CYCLE

Stromal–epithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ROS Signaling by NOX4 Drives Fibroblast-to-Myofibroblast Differentiation in the Diseased Prostatic Stroma

(2011) Natalie Sampson et al.   MOLECULAR ENDOCRINOLOGY

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue

(2010) Nicolai Treiber et al.   AGING CELL

Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

(2010) S. P. Kerkar et al.   CANCER RESEARCH

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Life Extension by Diet Restriction and N-Acetyl-L-Cysteine in Genetically Heterogeneous Mice

(2010) K. Flurkey et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets

(2010) Ju Dong Yang et al.   SEMINARS IN CANCER BIOLOGY

The inflammatory network: bridging senescent stroma and epithelial tumorigenesis

(2009) Weiwei Shan   Frontiers in Bioscience-Landmark

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Stroma in breast development and disease

(2009) Lisa M. Arendt et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL