Construction of N‐Heterocycles through Cyclization of Tertiary Amines

Direct Cyclization of Tertiary Aryl Amines with Iodonium Ylides

(2018) Zhiguo Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Magnesium Bisphosphate-Catalyzed Asymmetric Double C(sp3)–H Bond Functionalization Based on Sequential Hydride Shift/Cyclization Process

(2018) Keiji Mori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Construction of 8-Azabicyclo[3.2.1]octanes via Sequential DDQ-Mediated Oxidative Mannich Reactions of N-Aryl Pyrrolidines

(2018) Hanbyeol Jo et al.   ORGANIC LETTERS

Oxidative Cyclization Synthesis of Tetrahydroquinolines and Reductive Hydrogenation of Maleimides under Redox-Neutral Conditions

(2018) Xiu-Long Yang et al.   ORGANIC LETTERS

α-Aminoalkyl Radical Addition to Maleimides via Electron Donor–Acceptor Complexes

(2018) Chien-Wei Hsu et al.   ORGANIC LETTERS

Uncovering Multifaceted Iodonium Ylides: Versatile Reactivity Enables Cyclization of Simple Arylamines

(2018) Yao Wang et al.   SYNLETT

Chlorophyll-Catalyzed Visible-Light-Mediated Synthesis of Tetrahydroquinolines from N,N-Dimethylanilines and Maleimides

(2017) Jun-Tao Guo et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Ring-Fused 1-Benzazepines via [1,5]-Hydride Shift/7-Endo Cyclization Sequences

(2017) Chang Won Suh et al.   ORGANIC LETTERS

Rh-catalyzed aerobic oxidative cyclization of anilines, alkynes, and CO

(2017) Xinyao Li et al.   Chemical Science

Synthetic Utilization of α-Aminoalkyl Radicals and Related Species in Visible Light Photoredox Catalysis

(2016) Kazunari Nakajima et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Hydroxyphthalimide: a new photoredox catalyst for [4+1] radical cyclization of N-methylanilines with isocyanides

(2016) Arvind K. Yadav et al.   CHEMICAL COMMUNICATIONS

Dual C–H functionalization of N-aryl tetrahydroisoquinolines: a highly diastereoselective synthesis of dibenzo[a,f]quinolizines via visible-light induced oxidation and inverse electron-demand aza-Diels–Alder reaction

(2016) Guo-Qiang Xu et al.   CHEMICAL COMMUNICATIONS

Organo- and Organometallic-Catalytic Intramolecular [1,5]-Hydride Transfer/Cyclization Process through C(sp3)-H Bond Activation

(2016) Su Jin Kwon et al.   CHEMICAL RECORD

Advances in Synthetic Applications of Hypervalent Iodine Compounds

(2016) Akira Yoshimura et al.   CHEMICAL REVIEWS

“On Water” C(sp3)–H Functionalization/C–O/C–N Bonds Formations: Synthesis of Functionalized Oxazolidines and Imidazolidines

(2016) Vanaparthi Satheesh et al.   JOURNAL OF ORGANIC CHEMISTRY

Brønsted acid cocatalysis in photocatalytic intramolecular coupling of tertiary amines: efficient synthesis of 2-arylindols

(2016) Xiaoqian Yuan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catching α-aminoalkyl radicals: cyclization between tertiary alkylanilines and alkenes

(2016) Zengqiang Song et al.   TETRAHEDRON

Cobalt-catalyzed aerobic oxidative Povarov reaction of tertiary anilines with dihydrofuran for the synthesis of hexahydrofuroquinolines

(2016) Congde Huo et al.   TETRAHEDRON LETTERS

Cobalt-catalyzed oxidative annulation of aromatic tertiary amines with electron-deficient maleimides leading to tetrahydroquinoline derivatives

(2016) Norio Sakai et al.   TETRAHEDRON LETTERS

Iron-Catalyzed Dehydrogenative [4 + 2] Cycloaddition of Tertiary Anilines and Enamides for the Synthesis of Tetrahydroquinolines with Amido-Substituted Quaternary Carbon Centers

(2016) Mi-Na Zhao et al.   ACS Catalysis

Rhodium-Catalyzed Annulation of Tertiary Aniline N-Oxides to N-Alkylindoles: Regioselective C–H Activation, Oxygen-Atom Transfer, and N-Dealkylative Cyclization

(2016) Bin Li et al.   ACS Catalysis

The Baldwin rules: revised and extended

(2016) Kerry Gilmore et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Redox-Neutral Rhodium-Catalyzed CH Functionalization of ArylamineN-Oxides with Diazo Compounds: Primary C(sp3)H/C(sp2)H Activation and Oxygen-Atom Transfer

(2015) Bing Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Eosin Y-catalyzed visible-light-mediated aerobic oxidative cyclization ofN,N-dimethylanilines with maleimides

(2015) Zhongwei Liang et al.   Beilstein Journal of Organic Chemistry

Cu-catalyzed oxidative Povarov reactions between N-alkyl N-methylanilines and saturated oxa- and thiacycles

(2015) Rahul Kisan Kawade et al.   CHEMICAL COMMUNICATIONS

Construction of Oxadiazepines via Lewis Acid-Catalyzed Tandem 1,5-Hydride Shift/Cyclization

(2015) Yong-Zhi Chang et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible Light Mediated Cyclization of Tertiary Anilines with Maleimides Using Nickel(II) Oxide Surface-Modified Titanium Dioxide Catalyst

(2015) Jian Tang et al.   JOURNAL OF ORGANIC CHEMISTRY

Sulfonamide and Tertiary Amine as Nucleophiles in Pd(II)-Catalyzed Diamination of Alkynes: Synthesis of Tetracyclic Indolobenzothiazine S,S-Dioxides

(2015) Tu M. Ha et al.   ORGANIC LETTERS

A new synthesis of indoles via intramolecular cyclization of ο-alkynyl N,N-dialkylanilines promoted by KOt-Bu/DMSO

(2015) Yan-yan Chen et al.   TETRAHEDRON LETTERS

Brønsted Acid Cocatalysis in Copper(I)-Photocatalyzed α-Amino C–H Bond Functionalization

(2015) Thomas P. Nicholls et al.   ACS Catalysis

Advancement in Cascade [1,n]-Hydrogen Transfer/Cyclization: A Method for Direct Functionalization of Inactive C(sp3)H Bonds

(2014) Liang Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

CH Bond Functionalization through Intramolecular Hydride Transfer

(2014) Michael C. Haibach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Cyclization/aza-Claisen Rearrangement Cascade Initiated by Ketenimine Formation: An Efficient Stereocontrolled Synthesis of α-Allyl Cyclic Amidines

(2014) Hua-Dong Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Saturated N-Heterocycles

(2014) Cam-Van T. Vo et al.   JOURNAL OF ORGANIC CHEMISTRY

Double C(sp3)–H Bond Functionalization Mediated by Sequential Hydride Shift/Cyclization Process: Diastereoselective Construction of Polyheterocycles

(2014) Keiji Mori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gold-Catalyzed [1,5]-Hydride Shift onto Unactivated Alkynes To Trigger an Intermolecular Diels–Alder Reaction

(2014) Xiang Wu et al.   ORGANIC LETTERS

One-Pot Protocol to Functionalized Benzopyrrolizidine Catalyzed Successively by Rh2(OAc)4 and Cu(OTf)2: A Transition Metal–Lewis Acid Catalysis Relay

(2014) Hua-Dong Xu et al.   ORGANIC LETTERS

Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach

(2014) Chang Min et al.   ORGANIC LETTERS

Synthesis of 3-Acylindoles by Visible-Light Induced Intramolecular Oxidative Cyclization of o-Alkynylated N,N-Dialkylamines

(2014) Ping Zhang et al.   ORGANIC LETTERS

A Visible-Light-Mediated Synthesis of Carbazoles

(2013) Augusto C. Hernandez-Perez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium/Copper-Catalyzed Oxidative CH Alkenylation/N-Dealkylative Carbonylation of Tertiary Anilines

(2013) Renyi Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Regioselective Intramolecular Oxidative α-Functionalization of Tertiary Amines: An Efficient Synthesis of Dihydro-1,3-Oxazines

(2013) Mohit L. Deb et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient cyclization of tertiary amines and alkenes promoted by KOt-Bu–DMF

(2013) Yan-yan Chen et al.   CHEMICAL COMMUNICATIONS

Finding the right path: Baldwin “Rules for Ring Closure” and stereoelectronic control of cyclizations

(2013) Igor V. Alabugin et al.   CHEMICAL COMMUNICATIONS

tert-Amino effect: the Meth-Cohn and Reinhoudt reactions (Review)

(2013) A. Yu. Platonova et al.   Chemistry of Heterocyclic Compounds

The Redox-Neutral Approach to CH Functionalization

(2013) Bo Peng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Cross-Dehydrogenative Coupling Enabled by the Design and Application of Chiral Triazole-Containing Phosphoric Acids

(2013) Andrew J. Neel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxygen Switch in Visible-Light Photoredox Catalysis: Radical Additions and Cyclizations and Unexpected C–C-Bond Cleavage Reactions

(2013) Shaoqun Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intramolecular Dehydrative Coupling of Tertiary Amines and Ketones Promoted by KO-t-Bu/DMF: A New Synthesis of Indole Derivatives

(2013) Wen-tao Wei et al.   ORGANIC LETTERS

Catalytic asymmetric α-C(sp3)–H functionalization of amines

(2013) Yan Qin et al.   TETRAHEDRON LETTERS

A visible-light-promoted aerobic C–H/C–N cleavage cascade to isoxazolidine skeletons

(2013) Jin Xie et al.   Chemical Science

Photoredox activation and anion binding catalysis in the dual catalytic enantioselective synthesis of β-amino esters

(2013) Giulia Bergonzini et al.   Chemical Science

The Reaction of Tertiary Anilines with Maleimides under Visible Light Redox Catalysis

(2012) Xuhui Ju et al.   ADVANCED SYNTHESIS & CATALYSIS

Metal-Free Oxidation/C(sp3)H Functionalization of Unactivated Alkynes Using Pyridine-N-Oxide as the External Oxidant

(2012) Dian-Feng Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective tert-Aminocyclization by Asymmetric Binary Acid Catalysis (ABC): Stereospecific 1,5-Hydrogen Transfer

(2012) Liujuan Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mizoroki-Heck-Type Reaction Mediated by Potassium tert-Butoxide

(2011) Eiji Shirakawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Gold-Catalyzed Functionalization of Unreactive sp3 CH Bonds through a Redox-Neutral Domino Reaction

(2011) Guanghua Zhou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Catalyzed Oxidative Direct Cyclization ofN-Methylanilines with Electron-Deficient Alkenes Using Molecular Oxygen

(2011) Mayuko Nishino et al.   JOURNAL OF ORGANIC CHEMISTRY

Biocatalytic Organic Synthesis of Optically Pure (S)-Scoulerine and Berbine and Benzylisoquinoline Alkaloids

(2011) Joerg H. Schrittwieser et al.   JOURNAL OF ORGANIC CHEMISTRY

Selective Activation of Enantiotopic C(sp3)−Hydrogen by Means of Chiral Phosphoric Acid: Asymmetric Synthesis of Tetrahydroquinoline Derivatives

(2011) Keiji Mori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Concise Synthesis of Tetrabenazine: An Intramolecular Aza-Prins-Type Cyclization via Oxidative C–H Activation∥

(2011) Young Wook Son et al.   ORGANIC LETTERS

Highly Enantioselective Synthesis of Tetrahydroquinolines via Cobalt(II)-Catalyzed Tandem 1,5-Hydride Transfer/Cyclization

(2011) Weidi Cao et al.   ORGANIC LETTERS

Asymmetric Electrophilic Fluorination Using an Anionic Chiral Phase-Transfer Catalyst

(2011) V. Rauniyar et al.   SCIENCE

Platinum-catalyzed 1,3-acyloxy migration/[1,5]-hydride transfer/cycloaddition sequence: synthesis of ring-fused tetrahydroquinolines

(2011) Xiao-Feng Xia et al.   RSC Advances

Cu(ii) catalyzed oxidation-[3+2] cycloaddition-aromatization cascade: Efficient synthesis of pyrrolo [2, 1-a] isoquinolines

(2010) Chenguang Yu et al.   CHEMICAL COMMUNICATIONS

Enantioselective Organocatalytic C−H Bond Functionalization via Tandem 1,5-Hydride Transfer/Ring Closure: Asymmetric Synthesis of Tetrahydroquinolines

(2010) Young Ku Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Oxidative Amination of Benzoxazoles via C−H and C−N Bond Activation: A New Strategy for Using Tertiary Amines as Nitrogen Group Sources

(2010) Shengmei Guo et al.   ORGANIC LETTERS

The Benzyne Aza-Claisen Reaction

(2009) Alastair A. Cant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expeditious Construction of Quinazolines via Brønsted Acid-induced C–H Activation: Further Extension of “tert-Amino Effect”

(2009) Keiji Mori et al.   CHEMISTRY LETTERS

Catalytic Enantioselective Intramolecular Redox Reactions: Ring-Fused Tetrahydroquinolines

(2009) Sandip Murarka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Two-Step, Formal [4 + 2] Approach toward Piperidin-4-ones via Au Catalysis

(2009) Li Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CuBr-Catalyzed Reaction ofN,N-Dimethylanilines and Silyl Enol Ethers: An Alternative Route to β-Arylamino Ketones

(2009) Lehao Huang et al.   ORGANIC LETTERS

Gold or No Gold: One-Pot Synthesis of Tetrahydrobenz[b]azepin-4-ones from TertiaryN-(But-3-ynyl)anilines

(2009) Li Cui et al.   ORGANIC LETTERS

Synthesis of N-Fused Tricyclic Indoles by a Tandem [1,2] Stevens-Type Rearrangement/1,2-Alkyl Migration of Metal-Containing Ammonium Ylides

(2008) Jun Takaya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

[1,5]-Hydride Transfer/Cyclizations on Alkynyl Fischer Carbene Complexes: Synthesis of 1,2-Dihydroquinolinyl Carbene Complexes and Cascade Reactions

(2008) José Barluenga et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile Formation of Cyclic Aminals through a Brønsted Acid-Promoted Redox Process

(2008) Chen Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of substituted 1,2,3,4-tetrahydroquinones by the Povarov reaction. New potentials of the classical reaction

(2008) V A Glushkov et al.   RUSSIAN CHEMICAL REVIEWS