Listeriolysin O: A phagosome-specific cytolysin revisited

The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection

(2018) Chen Chen et al.   Cell Host & Microbe

Pore-forming activity of the Pseudomonas aeruginosa type III secretion system translocon alters the host epigenome

(2018) Laurent Dortet et al.   Nature Microbiology

Ubc9Is Required for Positive Selection and Late-Stage Maturation of Thymocytes

(2017) Aibo Wang et al.   JOURNAL OF IMMUNOLOGY

Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro

(2017) Jan G. Nel et al.   JOURNAL OF INFECTION

The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation

(2017) Mikaila Bandara et al.   MICROBES AND INFECTION

Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections

(2017) M Hassane et al.   Mucosal Immunology

Listeriolysin O: from bazooka to Swiss army knife

(2017) Suzanne E. Osborne et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection

(2017) David Ribet et al.   mBio

NLRP3 inflammasome activation contributes to Listeria monocytogenes-induced animal pregnancy failure

(2016) Wenyan Li et al.   BMC Veterinary Research

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins

(2016) Sara L. Lawrence et al.   STRUCTURE

The NADase-Negative Variant of the Streptococcus pyogenes Toxin NAD + Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis

(2016) Sukantha Chandrasekaran et al.   mBio

Suilysin-induced Platelet-Neutrophil Complexes Formation is Triggered by Pore Formation-dependent Calcium Influx

(2016) Shengwei Zhang et al.   Scientific Reports

Passive immunization with anti-ActA and anti-listeriolysin O antibodies protects against Listeria monocytogenes infection in mice

(2016) Krisana Asano et al.   Scientific Reports

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria

(2015) Rodney K. Tweten et al.   Annual Review of Microbiology

Intracellular Listeria monocytogenes Comprises a Minimal but Vital Fraction of the Intestinal Burden following Foodborne Infection

(2015) Grant S. Jones et al.   INFECTION AND IMMUNITY

Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+Efflux

(2015) Mausita Karmakar et al.   JOURNAL OF IMMUNOLOGY

Directly Observing the Lipid-Dependent Self-Assembly and Pore-Forming Mechanism of the Cytolytic Toxin Listeriolysin O

(2015) Estefania Mulvihill et al.   NANO LETTERS

New insights into gastrointestinal anthrax infection

(2015) Jennifer L. Owen et al.   TRENDS IN MOLECULAR MEDICINE

Degradation Products of the Extracellular Pathogen Streptococcus pneumoniae Access the Cytosol via Its Pore-Forming Toxin

(2015) Jamie K. Lemon et al.   mBio

Perfringolysin O: The Underrated Clostridium perfringens Toxin?

(2015) Stefanie Verherstraeten et al.   Toxins

Toll-like receptor 4 confers inflammatory response to Suilysin

(2015) Lili Bi et al.   Frontiers in Microbiology

DAMPs from Cell Death to New Life

(2015) Emilie Vénéreau et al.   Frontiers in Immunology

Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri

(2014) S. Fritah et al.   EMBO REPORTS

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread

(2014) Mark A. Czuczman et al.   NATURE

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity

(2014) Lucy K. Shewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of listeriolysin O reveals molecular details of oligomerization and pore formation

(2014) Stefan Köster et al.   Nature Communications

Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin

(2014) Carl Leung et al.   eLife

The Contribution of Suilysin to the Pathogenesis of Streptococcus suis Meningitis

(2013) Dan Takeuchi et al.   JOURNAL OF INFECTIOUS DISEASES

Reduction of Streptolysin O (SLO) Pore-Forming Activity Enhances Inflammasome Activation

(2013) Peter Keyel et al.   Toxins

More Than a Pore: The Cellular Response to Cholesterol-Dependent Cytolysins

(2013) Sara Cassidy et al.   Toxins

Pathogenic Pore-Forming Proteins: Function and Host Response

(2012) Mirko Bischofberger et al.   Cell Host & Microbe

Identification and Characterization of the First Cholesterol-Dependent Cytolysins from Gram-Negative Bacteria

(2012) Eileen M. Hotze et al.   INFECTION AND IMMUNITY

Export Requirements of Pneumolysin in Streptococcus pneumoniae

(2012) K. E. Price et al.   JOURNAL OF BACTERIOLOGY

ATP Release from Dying Autophagic Cells and Their Phagocytosis Are Crucial for Inflammasome Activation in Macrophages

(2012) Gizem Ayna et al.   PLoS One

Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells

(2012) A. J. Holland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Listeriolysin O: the Swiss army knife of Listeria

(2012) Mélanie Anne Hamon et al.   TRENDS IN MICROBIOLOGY

The Cholesterol-Dependent Cytolysin Signature Motif: A Critical Element in the Allosteric Pathway that Couples Membrane Binding to Pore Assembly

(2012) Kelley J. Dowd et al.   PLoS Pathogens

Bacillus anthracis Factors for Phagosomal Escape

(2012) Fiorella Tonello et al.   Toxins

Pore-forming toxins induce multiple cellular responses promoting survival

(2011) Manuel R. Gonzalez et al.   CELLULAR MICROBIOLOGY

K+Efflux Is Required for Histone H3 Dephosphorylation by Listeria monocytogenes Listeriolysin O and Other Pore-Forming Toxins

(2011) Mélanie Anne Hamon et al.   INFECTION AND IMMUNITY

The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia

(2011) M. Witzenrath et al.   JOURNAL OF IMMUNOLOGY

Critical Roles of ASC Inflammasomes in Caspase-1 Activation and Host Innate Resistance to Streptococcus pneumoniae Infection

(2011) R. Fang et al.   JOURNAL OF IMMUNOLOGY

Listeria monocytogenestransiently alters mitochondrial dynamics during infection

(2011) Fabrizia Stavru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity

(2011) J.-D. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Functional Analyses of Cellular Responses to Pore-Forming Toxins

(2011) Cheng-Yuan Kao et al.   PLoS Pathogens

The role of anthrolysin O in gut epithelial barrier disruption during Bacillus anthracis infection

(2010) Brian L. Bishop et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage Cytosol

(2010) John-Demian Sauer et al.   Cell Host & Microbe

Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice

(2010) Maud D. Demarque et al.   GASTROENTEROLOGY

Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against Bordetella pertussis

(2010) A. Dunne et al.   JOURNAL OF IMMUNOLOGY

Differential Regulation of Caspase-1 Activation via NLRP3/NLRC4 Inflammasomes Mediated by Aerolysin and Type III Secretion System during Aeromonas veronii Infection

(2010) A. J. McCoy et al.   JOURNAL OF IMMUNOLOGY

Listeria monocytogenes impairs SUMOylation for efficient infection

(2010) David Ribet et al.   NATURE

Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface

(2010) A. J. Farrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-Time Observation of Listeria monocytogenes-Phagocyte Interactions in Living Zebrafish Larvae

(2009) J.-P. Levraud et al.   INFECTION AND IMMUNITY

Listeria monocytogenes-Infected Human Peripheral Blood Mononuclear Cells Produce IL-1 , Depending on Listeriolysin O and NLRP3

(2009) K. Meixenberger et al.   JOURNAL OF IMMUNOLOGY

Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF- B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

(2009) J. Harder et al.   JOURNAL OF IMMUNOLOGY

Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

(2009) Jessica Chu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

Phosphatase-Dependent Regulation of Epithelial Mitogen-Activated Protein Kinase Responses to Toxin-Induced Membrane Pores

(2009) Jorge L. Aguilar et al.   PLoS One

Passive administration of monoclonal antibodies to Anthrolysin O prolong survival in mice lethally infected with Bacillus anthracis

(2008) Antonio Nakouzi et al.   BMC MICROBIOLOGY

Functional and Phylogenetic Characterization of Vaginolysin, the Human-Specific Cytolysin from Gardnerella vaginalis

(2008) S. E. Gelber et al.   JOURNAL OF BACTERIOLOGY

GILT is a critical host factor for Listeria monocytogenes infection

(2008) Reshma Singh et al.   NATURE