Inhibition of the PI3K/AKT pathway potentiates cytotoxicity of EGFR kinase inhibitors in triple-negative breast cancer cells

Dissecting the Heterogeneity of Triple-Negative Breast Cancer

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Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells

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BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site

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AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

(2011) Sarat Chandarlapaty et al.   CANCER CELL

The epidermal growth factor receptor/Erb-B/HER family in normal and malignant breast biology

(2011) Suzanne A. Eccles   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

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PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

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Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors

(2011) A. Chakrabarty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase

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What Is the Difference Between Triple-Negative and Basal Breast Cancers?

(2010) Melanie D. Seal et al.   CANCER JOURNAL

Epidermal Growth Factor Receptor in Triple-Negative and Basal-Like Breast Cancer

(2010) Monika L. Burness et al.   CANCER JOURNAL

Prognostic and Therapeutic Implications of Distinct Kinase Expression Patterns in Different Subtypes of Breast Cancer

(2010) G. Bianchini et al.   CANCER RESEARCH

Distinct Biological Roles for the Akt Family in Mammary Tumor Progression: Figure 1.

(2010) Rachelle L. Dillon et al.   CANCER RESEARCH

Emerging Targeted Therapies for Breast Cancer

(2010) Ricardo H. Alvarez et al.   JOURNAL OF CLINICAL ONCOLOGY

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

X-Linked Inhibitor of Apoptosis Protein Inhibits Apoptosis in Inflammatory Breast Cancer Cells with Acquired Resistance to an ErbB1/2 Tyrosine Kinase Inhibitor

(2010) K. M. Aird et al.   MOLECULAR CANCER THERAPEUTICS

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

Triple-negative breast cancer: Present challenges and new perspectives

(2010) Franca Podo et al.   Molecular Oncology

Triple-negative breast cancer: disease entity or title of convenience?

(2010) Lisa Carey et al.   Nature Reviews Clinical Oncology

Understanding resistance to EGFR inhibitors—impact on future treatment strategies

(2010) Deric L. Wheeler et al.   Nature Reviews Clinical Oncology

Loss of BRCA1 leads to an increased sensitivity to Bisphenol A

(2010) Laundette P. Jones et al.   TOXICOLOGY LETTERS

Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer

(2009) B. Corkery et al.   ANNALS OF ONCOLOGY

Target-based therapies in breast cancer: current status and future perspectives

(2009) Nicola Normanno et al.   ENDOCRINE-RELATED CANCER

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

(2008) D Li et al.   ONCOGENE

mTORC1 promotes survival through translational control of Mcl-1

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