A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

(2016) Rowena L. Sison-Young et al.   ARCHIVES OF TOXICOLOGY

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Fast and Sensitive Total Protein and Peptide Assays for Proteomic Analysis

(2015) Jacek R. Wiśniewski et al.   ANALYTICAL CHEMISTRY

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

(2015) Anna Vildhede et al.   JOURNAL OF PROTEOME RESEARCH

The Reactome pathway Knowledgebase

(2015) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Rapid and Sensitive Assessment of Human Hepatocyte Functions

(2014) Roberto Gramignoli et al.   CELL TRANSPLANTATION

Multi-enzyme digestion FASP and the ‘Total Protein Approach’-based absolute quantification of the Escherichia coli proteome

(2014) Jacek R. Wiśniewski et al.   Journal of Proteomics

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)

(2013) Jenny M. Pedersen et al.   TOXICOLOGICAL SCIENCES

Massive palmitoylation-dependent endocytosis during reoxygenation of anoxic cardiac muscle

(2013) Mei-Jung Lin et al.   eLife

Consecutive Proteolytic Digestion in an Enzyme Reactor Increases Depth of Proteomic and Phosphoproteomic Analysis

(2012) Jacek R. Wiśniewski et al.   ANALYTICAL CHEMISTRY

Understanding the Critical Disposition Pathways of Statins to Assess Drug–Drug Interaction Risk During Drug Development: It's Not Just About OATP1B1

(2012) R Elsby et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Ischaemia–reperfusion injury in liver transplantation—from bench to bedside

(2012) Yuan Zhai et al.   Nature Reviews Gastroenterology & Hepatology

Plateable cryopreserved human hepatocytes for the assessment of cytochrome P450 inducibility: experimental condition-related variables affecting their response to inducers

(2012) Eliane Alexandre et al.   XENOBIOTICA

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

(2011) Megan Roth et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Quantitative Spatial Proteomics Analysis of Proteome Turnover in Human Cells

(2011) François-Michel Boisvert et al.   MOLECULAR & CELLULAR PROTEOMICS

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

N-Acetylcysteine Improves the Viability of Human Hepatocytes Isolated from Severely Steatotic Donor Liver Tissue

(2010) Filippos G. Sagias et al.   CELL TRANSPLANTATION

Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

(2010) Brandon Swift* et al.   DRUG METABOLISM REVIEWS

Preapoptotic cell stress response of primary hepatocytes

(2010) Damijan Nipič et al.   HEPATOLOGY

Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation

(2010) Ricky Harminder Bhogal et al.   LIVER TRANSPLANTATION

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY