Plateable cryopreserved human hepatocytes for the assessment of cytochrome P450 inducibility: experimental condition-related variables affecting their response to inducers

Effect of cryopreservation on the activity of OATP1B1/3 and OCT1 in isolated human hepatocytes

(2011) Lassina Badolo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes

(2011) Tom De Bruyn et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A 96-Well Plate Assay for CYP4503A Induction Using Cryopreserved Human Hepatocytes

(2010) N. Kamiguchi et al.   DRUG METABOLISM AND DISPOSITION

Expression Levels of Drug-Metabolizing Enzyme, Transporter, and Nuclear Receptor mRNAs in a Novel Three-Dimensional Culture System for Human Hepatocytes Using Micro-space Plates

(2010) Masuhiro Nishimura et al.   Drug Metabolism and Pharmacokinetics

Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

(2010) Brandon Swift* et al.   DRUG METABOLISM REVIEWS

Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation

(2010) Claire Terry et al.   LIVER TRANSPLANTATION

Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction ofin vivoclearance

(2010) Joanne A. Foster et al.   XENOBIOTICA

Influence of Seeding Density and Extracellular Matrix on Bile Acid Transport and Mrp4 Expression in Sandwich-Cultured Mouse Hepatocytes

(2009) Brandon Swift et al.   MOLECULAR PHARMACEUTICS

Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions

(2009) Catherine Abadie-Viollon et al.   TOXICOLOGY IN VITRO

Inter-laboratory evaluation of the response of primary human hepatocyte cultures to model CYP inducers – A European Centre for Validation of Alternative Methods (ECVAM) – Funded pre-validation study

(2009) Lysiane Richert et al.   TOXICOLOGY IN VITRO

Cytochrome P450 Induction by Rifampicin in Healthy Subjects: Determination Using the Karolinska Cocktail and the Endogenous CYP3A4 Marker 4β-Hydroxycholesterol

(2008) KP Kanebratt et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

An update on metabolism studies using human hepatocytes in primary culture

(2008) María José Gómez-Lechón et al.   Expert Opinion on Drug Metabolism & Toxicology

Differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes

(2008) Severine Illouz et al.   PHYTOTHERAPY RESEARCH

Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes

(2008) L. Richert et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A newin vitroapproach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations

(2007) Agustín Lahoz et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY