Article
Biochemistry & Molecular Biology
Duo Wang, Zirui Zeng, Mengyue Shen, Ryuji Okazaki, Hironori Miyata, Tomo Yonezawa, Yasuhiro Yoshida
Summary: Neutrophil endocytosis is closely related to ATP-centered energy metabolism. Inhibition of dynamin inhibits ATP consumption triggered by neutrophil endocytosis, while inhibition of ATP synthase and nicotinamide adenine dinucleotide phosphate oxidase suppresses neutrophil endocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ryo Koyama, Koichi Iwata, Yoshinori Hayashi, Suzuro Hitomi, Ikuko Shibuta, Akihiko Furukawa, Sayaka Asano, Tadayoshi Kaneko, Yoshiyuki Yonehara, Masamichi Shinoda
Summary: The study revealed that pain in tongue cancer patients is caused by upregulation of PANX1 in microglia in the trigeminal spinal subnucleus caudalis, leading to ATP activation of nociceptive neurons in the Vc and ultimately resulting in tongue cancer pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Yaru Xu, Ge Gao, Xiaoru Sun, Qidong Liu, Cheng Li
Summary: Postoperative delirium (POD) is a major complication after surgery with general anesthesia, and the neurotoxicity of general anesthetics plays a key role. Sevoflurane, a common general anesthetic, is shown to induce inflammatory response and caspase-3 activation through upregulation of ATPIF1 in microglia. ATP supplementation may be a potential therapeutic strategy for alleviating sevoflurane-induced POD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biology
Ryan C. F. Siu, Anna Kotova, Ksenia Timonina, Christiane Zoidl, Georg R. Zoidl
Summary: The study highlights the interplay between Connexin-36 (Cx36), NMDA receptor, and Pannexin 1 in calcium signaling in neuronal cells. It shows that CaMKII binding to Cx36 increases gap junction opening, with NMDA receptor and Pannexin 1 playing crucial roles. The research emphasizes the importance of calcium-dependent signaling in modulating the efficacy of Cx36 channels.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniela Ivanova, Katharine L. Dobson, Akshada Gajbhiye, Elizabeth C. Davenport, Daniela Hacker, Sila K. Ultanir, Matthias Trost, Michael A. Cousin
Summary: The study reveals that regulating the copy number of the noncanonical vesicular SNARE protein VAMP4 on synaptic vesicles is crucial for controlling neurotransmitter release probability. VAMP4, with high synaptic turnover, is selectively sorted to endolysosomes during activity-dependent bulk endocytosis, disrupting which can lead to an increase in VAMP4 abundance in the SV pool and inhibition of SV fusion.
Article
Multidisciplinary Sciences
Ross Luu, Silvana Valdebenito, Eliana Scemes, Antonio Cibelli, David C. Spray, Maximiliano Rovegno, Juan Tichauer, Andrea Cottignies-Calamarte, Arielle Rosenberg, Calude Capron, Sandrine Belouzard, Jean Dubuisson, Djillali Annane, Geoffroy Lorin de la Grandmaison, Elisabeth Cramer-Borde, Morgane Bomsel, Eliseo Eugenin
Summary: The study found that SARS-CoV-2 induces a more significant and prolonged opening of Panx-1 channels compared to other viruses, leading to increased release of ATP, PGE(2), and IL-1 beta. Therefore, the Panx-1 channel is considered a critical factor in SARS-CoV-2 infection and could be a potential alternative therapy.
Article
Cell Biology
Desiree Forstner, Jacqueline Guettler, Beatrice A. Brugger, Freya Lyssy, Lena Neuper, Christine Daxboeck, Gerhard Cvirn, Julia Fuchs, Kristin Kraeker, Alina Frolova, Daniela S. Valdes, Christina Stern, Birgit Hirschmugl, Herbert Fluhr, Christian Wadsack, Berthold Huppertz, Olivia Nonn, Florian Herse, Martin Gauster
Summary: Tissue insults in response to inflammation, hypoxia and ischemia cause the release of ATP, which modulates various pathological processes. CD39 and CD73 are two major enzymes that convert extracellular ATP into adenosine. This study investigated the expression of CD39 and CD73 in placental tissue and their regulation in response to platelet-derived factors and oxygen conditions. The results showed that placental CD39 expression increased in preeclampsia and platelet-derived factors led to deregulated CD39 expression. CD39 overexpression decreased extracellular ATP levels and abolished the upregulation of pro-inflammatory cytokine interleukin-1 beta. These findings suggest that increased placental CD39 could be an important anti-coagulant defense mechanism of the placenta.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Paula P. Coelho, Geoffrey G. Hesketh, Annika Pedersen, Elena Kuzmin, Anne-Marie N. Fortier, Emily S. Bell, Colin D. H. Ratcliffe, Anne-Claude Gingras, Morag Park
Summary: This study uncovers an LC3C-Endocytic-Associated-Pathway (LEAP) that selectively recruits plasma membrane cargo to autophagosomes, providing new understanding of the selective coupling of plasma membrane signaling with autophagic degradation.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Karel P. Alcedo, Jessica L. Bowser, Natasha T. Snider
Summary: Purinergic signaling is a fundamental mechanism used by all cells to control their internal activities and interact with the environment. CD73, a key component of the purinergic system, has been studied in cancer therapy, but recent research shows its complex role in cellular homeostasis, physiological adaptation, and disease development.
TRENDS IN CELL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Nadine Mundt, Lina Kenzler, Marc Spehr
Summary: Adenosine triphosphate (ATP) is not only the essential source of cellular energy, but also functions as an extracellular signal that activates purinergic receptors. Purinergic signaling plays a crucial role in male reproductive system functions, particularly in spermatogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Estefaniia Delgado-Pinar, Matilde Medeiros, Telma Costa, J. Sergio Seixas de Melo
Summary: Chemical derivatives of PEI with either TPA or Cou can form stable complexes with adenine and guanine nucleotides in water based on noncovalent interactions such as pi-pi stacking and hydrogen bonding. PEI-TPA acts as a chemosensor with recognition based on AIE and pi-pi interaction, while the Cou derivative relies on electrostatic interaction. The study provides valuable insights into designing receptors for selective recognition of nucleotides in water.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Medicine, Research & Experimental
Carina Herman de Sousa, Maria Adelina Costa, Rafaela Pedro Silva, Fatima Ferreirinha, Severino Ribeiro, Paulo Correia-de-Sa
Summary: This study demonstrates for the first time the overexpression of Panx1 in HSCF induced by A(2A)R, indirectly implicating ATP release in the fibrogenic vicious cycle operated by adenosine accumulating in subcutaneous tissue fibrosis and myofascial pain associated with dermal inflammation.
Article
Hematology
Ivana Bertovic, Roberta Kurelic, Hana Mahmutefendic Lucin, Antonija Jurak Begonja
Summary: Rab5-dependent endocytosis plays an important role in megakaryocytes receptor trafficking and membrane formation during thrombopoiesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biology
Jack Greiner, Thomas Glonek
Summary: The lens and muscle tissues have high concentrations of ATP despite low metabolic requirements, suggesting a non-metabolic function of ATP in cellular and tissue function evolution.
Article
Biochemistry & Molecular Biology
Yu Zhang, Ying-Jie Zhu, Han-Ping Yu
Summary: Ultralong hydroxyapatite (HAP) nanowires have potential biomedical applications due to their similarity to bone composition and excellent properties. However, controlling their formation and the long synthesis time have been challenging. This study introduces an eco-friendly microwave hydrothermal method that uses adenosine 5'-triphosphate (ATP) as a bio-phosphorus source and water as the only solvent for rapid synthesis of ultralong HAP nanowires. The resulting nanowires show high flexibility, self-assemble into bundles, and have excellent bioactivity on chitosan scaffolds.
Article
Neurosciences
Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Jagroop Dhaliwal, Esther O. Carmona-Wagner, Valery I. Shestopalov, Diane C. Lagace, Leigh Anne Swayne
JOURNAL OF NEUROSCIENCE
(2016)
Article
Biochemical Research Methods
Adrianna N. Gunton, Juan C. Sanchez-Arias, Esther O. Carmona-Wagner, Leigh E. Wicki-Stordeur, Leigh Anne Swayne
PROTEOMICS CLINICAL APPLICATIONS
(2017)
Editorial Material
Biology
Brian A. MacVicar, Leigh Wicki-Stordeur, Louis-Philippe Bernier
Article
Biochemistry & Molecular Biology
Leigh E. Wicki-Stordeur, Andrew K. J. Boyce, Leigh Anne Swayne
CELL COMMUNICATION AND ADHESION
(2013)
Article
Cell Biology
Leigh E. Wicki-Stordeur, Leigh Anne Swayne
CELL COMMUNICATION AND SIGNALING
(2013)
Review
Biochemistry & Molecular Biology
Leigh Anne Swayne, Leigh E. Wicki-Stordeur
Review
Biochemistry & Molecular Biology
Andrew K. J. Boyce, Ross T. Prager, Leigh E. Wicki-Stordeur, Leigh Anne Swayne
Article
Developmental Biology
Leigh E. Wicki-Stordeur, Adrian D. Dzugalo, Rose M. Swansburg, Jocelyne M. Suits, Leigh Anne Swayne
NEURAL DEVELOPMENT
(2012)
Review
Neurosciences
Leigh E. Wicki-Stordeur, Leigh A. Swayne
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Review
Cell & Tissue Engineering
Leigh E. Wicki-Stordeur, Leigh Anne Swayne
STEM CELLS INTERNATIONAL
(2012)
Review
Physiology
Andrew K. J. Boyce, Leigh E. Wicki-Stordeur, Leigh Anne Swayne
FRONTIERS IN PHYSIOLOGY
(2014)
Article
Cell Biology
Juan C. Sanchez Arias, Leigh E. Wicki-Stordeur, Rebecca C. Candlish, Emma van der Slagt, Irina Paci, Praveen P. N. Rao, Brian A. MacVicar, Leigh Anne Swayne
Review
Neurosciences
Alexandra L. Schober, Leigh E. Wicki-Stordeur, Keith K. Murai, Leigh Anne Swayne
Summary: Astrocytes have diverse roles in regulating brain circuit formation and physiology. Recent advancements have revealed a high level of diversity in astrocytes, including molecular, morphological, and functional differences. This diversification begins during embryonic specification events and continues into the early postnatal period, overlapping with synapse development and circuit refinement. There is evidence of molecular crosstalk among astrocytes, neurons, and synapses, suggesting that astrocyte diversity is influenced by and influences this crosstalk. Understanding astrocyte heterogeneity is vital for studying neurological diseases.
TRENDS IN NEUROSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Simona D. Frederiksen, Leigh E. Wicki-Stordeur, Leigh Anne Swayne
Summary: This study explores the connections between neurological conditions and genetic susceptibility, identifying potential links between the pannexin 1 (PANX1) channel and synaptic disease mechanisms. The study also reveals an overlap in risk genes for autism spectrum disorders and schizophrenia.