Article
Developmental Biology
Yimei Dai, Shuting Wu, Canran Cao, Rongtao Xue, Xuefen Luo, Zilong Wen, Jin Xu
Summary: Through studying zebrafish, we have discovered a surprising role of Csf1rb in maintaining the pool of hematopoietic stem and progenitor cells (HSPCs). This study reveals a novel function of Csf1r in maintaining HSPCs, independently of known ligands.
Article
Biochemistry & Molecular Biology
Zhichao Zhang, Xiaoyan Zheng, Yingfei Liu, Yan Luan, Li Wang, Lingyu Zhao, Jianshui Zhang, Yumei Tian, Haixia Lu, Xinlin Chen, Yong Liu
Summary: Activation of mGluR4 in SVZ-derived NSPCs suppresses proliferation and enhances neuronal differentiation, with regulation of PTEN potentially serving as an intracellular target of mGluR4 signaling.
JOURNAL OF NEUROCHEMISTRY
(2021)
Editorial Material
Cell Biology
Victor Tarabykin
Summary: The study highlights the essential role of the SNAP23-VAMP8-Syntaxin1B complex in the establishment of cell polarity in neuronal progenitors by mediating membrane targeting of N-cadherin and formation of adherence junction complexes.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biology
Mamta Verma, Mohd. Imran K. Khan, Rajashekar Varma Kadumuri, Baskar Chakrapani, Sharad Awasthi, Arun Mahesh, Gayathri Govindaraju, Pavithra L. Chavali, Arumugam Rajavelu, Sreenivas Chavali, Arunkumar Dhayalan
Summary: This study demonstrates that protein arginine methyltransferase 3 (PRMT3) interacts with and inhibits retinal dehydrogenase ALDH1A1, negatively regulating the expression of retinoic acid responsive genes. PRMT3 affects diverse biological processes not only by globally regulating protein function through methylation but also by regulating gene expression.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Chanyi Lu, Xiaoli Lin, Jumpei Yamashita, Ranhui Xi, Minliang Zhou, Yali Zhang, Hong Wang, Robert E. Margolskee, Bon-Kyoung Koo, Hans Clevers, Ichiro Matsumoto, Peihua Jiang
Summary: The study reveals the important roles of RNF43/ZNRF3 in regulating taste and lingual epithelial tissue homeostasis. R-spondin interacts with RNF43/ZNRF3 to enhance WNT signaling, thereby controlling taste cell regeneration and lingual epithelial tissue homeostasis.
Article
Developmental Biology
Jessica W. Bertol, Shelby Johnston, Rabia Ahmed, Victoria K. Xie, Kelsea M. Hubka, Lissette Cruz, Larissa Nitschke, Marta Stetsiv, Jeremy P. Goering, Paul Nistor, Sally Lowell, Hanne Hoskens, Peter Claes, Seth M. Weinberg, Irfan Saadi, Mary C. Farach-Carson, Walid D. Fakhouri
Summary: This study elucidates the mechanistic role of Twist1 and Irf6 in the neural tube and cranial neural crest cells (CNCCs), highlighting their importance in the epithelial-to-mesenchymal transition and cell migration processes.
Article
Immunology
Lifei Hou, Koichi Yuki
Summary: CD11a plays a critical role in leukocyte arrest and immunological synapse formation, but its role in the bone marrow is not well studied. This research showed that CD11a is expressed on all subsets of hematopoietic stem and progenitor cells (HPSCs). CD11a deficiency enhances HSPCs activity under LPS stimulation, possibly by upregulating the production of IL-27 to promote cell proliferation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Chen-Guang Zhao, Jie Qin, Jia Li, Shan Jiang, Fen Ju, Wei Sun, Zhen Ren, Yu-Qiang Ji, Rui Wang, Xiao-Long Sun, Xiang Mou, Hua Yuan
Summary: LINGO-1 shRNA promotes neural differentiation of sp-NSPCs and Wnt5a expression, potentially by downregulating miR-15b-3p. Transplantation of LINGO-1 shRNA-treated NSPCs enhances motor function recovery after SCI, suggesting its potential as a therapeutic target.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Carlos W. Gantner, Cameron P. J. Hunt, Jonathan C. Niclis, Vanessa Penna, Stuart J. McDougall, Lachlan H. Thompson, Clare L. Parish
Summary: Research has shown that by modulating the FGF and Notch signaling pathways, the fate and cell cycle of neural stem cells can be influenced, thereby affecting the layer specificity of the generated neurons. Notch inhibition leads to rapid generation of deep-layer VI neurons, while prolonged FGF2 exposure maintains progenitor identity and delays laminar progression.
Article
Biochemistry & Molecular Biology
Amel Ben Saad, Virginie Vauthier, Martine Lapalus, Elodie Mareux, Evangeline Bennana, Anne-Marie Durand-Schneider, Alix Bruneau, Jean-Louis Delaunay, Emmanuel Gonzales, Chantal Housset, Tounsia Ait-Slimane, Francois Guillonneau, Emmanuel Jacquemin, Thomas Falguieres
Summary: ABCB4 is an ABC transporter crucial for phosphatidylcholine secretion into bile. Research has identified RAB10 as a novel molecular partner of ABCB4, influencing its plasma membrane expression and function. Understanding the interactions between RAB10 and ABCB4 may lead to the development of novel therapies for liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Minhao Chen, Yingjuan Li, Longfei Xiao, Guangchun Dai, Panpan Lu, Yunfeng Rui
Summary: This study reveals that enhanced expression of Wnt5a in aged TSPCs leads to senescence, and inhibiting Wnt5a can attenuate senescence through modulating the JAK-STAT signaling pathway. Furthermore, Ror2 acts as the functional receptor of Wnt5a in TSPCs senescence by potentiate the JAK-STAT signaling pathway.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Xinyue Li, Guangyu Ji, Juan Zhou, Jingyi Du, Xian Li, Wei Shi, Yong Hu, Wenjuan Zhou, Aijun Hao
Summary: The study suggests that Pcgf1 functions as both a facilitator for pluripotent maintenance and a repressor for neural induction during early development, as evidenced by various phenotypic and gene expression changes observed in the zebrafish embryos and P19 cells with knocked down Pcgf1. This dual role of Pcgf1 sheds light on its importance in regulating neural tube development and neural induction processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Shizheng Zhao, Ao Zhang, Hao Zhu, Zilong Wen
Summary: The study reports the identification and characterization of a new member of the ETS transcription factors, Spi2, in ray-finned fish. It shows that Spi2 is crucial for hematopoietic stem and progenitor cell development and myeloid lineage differentiation. A reporter line is created to track these cells from early development to adulthood.
Article
Cell & Tissue Engineering
Naoya Yuizumi, Yujin Harada, Takaaki Kuniya, Takehiko Sunabori, Masato Koike, Masaki Wakabayashi, Yasushi Ishihama, Yutaka Suzuki, Daichi Kawaguchi, Yukiko Gotoh
Summary: Lysosomes play a crucial role in regulating the differentiation of neural stem-progenitor cells in the embryonic brain, with TFEB and TFE3 potentially maintaining the undifferentiated state of NPCs through controlling lysosomal biosynthesis. The abundance of lysosomes is associated with cell division activity and the embryonic origin of adult NSCs. TFEB-AA overexpression suppresses neuronal differentiation and the cell cycle of neocortical NPCs.
Article
Agronomy
Meiqing Xing, Wei Wang, Xing Fang, Hongwei Xue
Summary: Leaf inclination, an important component of crop architecture, is regulated by the phytohormones auxin and brassinosteroids. This study reveals the genetic control of leaf inclination and the synergistic effects of auxin and brassinosteroids in rice.
Article
Biochemistry & Molecular Biology
Andrew K. J. Boyce, Michelle S. Kim, Leigh E. Wicki-Stordeur, Leigh Anne Swayne
BIOCHEMICAL JOURNAL
(2015)
Article
Neurosciences
Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Jagroop Dhaliwal, Esther O. Carmona-Wagner, Valery I. Shestopalov, Diane C. Lagace, Leigh Anne Swayne
JOURNAL OF NEUROSCIENCE
(2016)
Article
Biochemical Research Methods
Adrianna N. Gunton, Juan C. Sanchez-Arias, Esther O. Carmona-Wagner, Leigh E. Wicki-Stordeur, Leigh Anne Swayne
PROTEOMICS CLINICAL APPLICATIONS
(2017)
Editorial Material
Biology
Brian A. MacVicar, Leigh Wicki-Stordeur, Louis-Philippe Bernier
Article
Biochemistry & Molecular Biology
Leigh E. Wicki-Stordeur, Andrew K. J. Boyce, Leigh Anne Swayne
CELL COMMUNICATION AND ADHESION
(2013)
Review
Biochemistry & Molecular Biology
Leigh Anne Swayne, Leigh E. Wicki-Stordeur
Review
Biochemistry & Molecular Biology
Andrew K. J. Boyce, Ross T. Prager, Leigh E. Wicki-Stordeur, Leigh Anne Swayne
Article
Developmental Biology
Leigh E. Wicki-Stordeur, Adrian D. Dzugalo, Rose M. Swansburg, Jocelyne M. Suits, Leigh Anne Swayne
NEURAL DEVELOPMENT
(2012)
Review
Neurosciences
Leigh E. Wicki-Stordeur, Leigh A. Swayne
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Review
Cell & Tissue Engineering
Leigh E. Wicki-Stordeur, Leigh Anne Swayne
STEM CELLS INTERNATIONAL
(2012)
Review
Physiology
Andrew K. J. Boyce, Leigh E. Wicki-Stordeur, Leigh Anne Swayne
FRONTIERS IN PHYSIOLOGY
(2014)
Article
Cell Biology
Juan C. Sanchez Arias, Leigh E. Wicki-Stordeur, Rebecca C. Candlish, Emma van der Slagt, Irina Paci, Praveen P. N. Rao, Brian A. MacVicar, Leigh Anne Swayne
Review
Neurosciences
Alexandra L. Schober, Leigh E. Wicki-Stordeur, Keith K. Murai, Leigh Anne Swayne
Summary: Astrocytes have diverse roles in regulating brain circuit formation and physiology. Recent advancements have revealed a high level of diversity in astrocytes, including molecular, morphological, and functional differences. This diversification begins during embryonic specification events and continues into the early postnatal period, overlapping with synapse development and circuit refinement. There is evidence of molecular crosstalk among astrocytes, neurons, and synapses, suggesting that astrocyte diversity is influenced by and influences this crosstalk. Understanding astrocyte heterogeneity is vital for studying neurological diseases.
TRENDS IN NEUROSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Simona D. Frederiksen, Leigh E. Wicki-Stordeur, Leigh Anne Swayne
Summary: This study explores the connections between neurological conditions and genetic susceptibility, identifying potential links between the pannexin 1 (PANX1) channel and synaptic disease mechanisms. The study also reveals an overlap in risk genes for autism spectrum disorders and schizophrenia.