Article
Oncology
Keli Lima, Livia Bassani Lins de Miranda, Anali Del Milagro Bernabe Garnique, Bruna Oliveira de Almeida, Mariane Cristina do Nascimento, Guilherme Augusto Sousa Alcantara, Glaucia Maria Machado-Santelli, Eduardo Magalhaes Rego, Joao Agostinho Machado-Neto
Summary: AD80, a multikinase inhibitor, exhibits antineoplastic effects in pancreatic cancer cells by reducing cell viability and inducing mitotic aberrations, autophagy, and apoptosis. The drug also modulates several genes and signaling pathways, providing insights into potential therapeutic strategies for pancreatic cancer.
Article
Oncology
Moumita Kundu, Subhayan Das, Chandan Kanta Das, Gaurav Kulkarni, Soumen Das, Dibakar Dhara, Mahitosh Mandal
Summary: Glioma is difficult to treat due to its invasive nature and the blood-brain barrier. This study discovered that Magnolol, a neolignan, plays an important role in inducing apoptosis and modulating autophagy in glioma cells. The study also found that Magnolol inhibits the PI3K/AKT/mTOR pathway to induce autophagy. The results suggest that Magnolol could be a promising therapeutic agent for glioma management.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Chemistry, Applied
Afshin Alimohammadi, Mir-Hassan Moosavy, Mohammad Amin Doustvandi, Behzad Baradaran, Mohammad Amini, Ahad Mokhtarzadeh, Miguel de la Guardia
Summary: The study demonstrated that sodium metabisulfite (SMB) significantly reduced viability of human normal cells through induction of apoptosis. Furthermore, SMB increased ROS levels and activated autophagy, indicating additional mechanisms of cell damage. The widespread use of SMB in food safety should be reconsidered based on these findings.
Article
Cell Biology
Pau Munoz-Guardiola, Josefina Casas, Elisabet Megias-Roda, Sonia Sole, Hector Perez-Montoyo, Marc Yeste-Velasco, Tatiana Erazo, Nora Dieguez-Martinez, Sergio Espinosa-Gil, Cristina Munoz-Pinedo, Guillermo Yoldi, Jose L. Abad, Miguel F. Segura, Teresa Moran, Margarita Romeo, Joaquim Bosch-Barrera, Ana Oaknin, Jose Alfon, Carles Domenech, Gemma Fabrias, Guillermo Velasco, Jose M. Lizcano
Summary: ABTL0812 induces cytotoxic autophagy in cancer cells by increasing cellular long-chain dihydroceramides and impairing DEGS1 activity, leading to sustained ER stress and activation of the unfolded protein response (UPR). This discovery suggests that manipulation of dihydroceramide levels could be a new therapeutic strategy for targeting cancer.
Article
Biochemistry & Molecular Biology
Audrey Lequeux, Muhammad Zaeem Noman, Malina Xiao, Kris Van Moer, Meriem Hasmim, Alice Benoit, Manon Bosseler, Elodie Viry, Tsolere Arakelian, Guy Berchem, Salem Chouaib, Bassam Janji
Summary: Inhibition of HIF-1 alpha transcriptional activity can increase levels of NK and CD8(+) T cells in the tumor microenvironment, enhancing the efficacy of cancer immunotherapy. Combining acriflavine can significantly improve the benefits of cancer immunotherapy based on TRP-2 peptide vaccination and anti-PD-1 blocking antibody, while melanoma patients with high CCL5 levels have a higher survival rate.
Article
Biochemistry & Molecular Biology
Qian Zhou, Gang Fang, Yuzhou Pang, Xueni Wang
Summary: This study found that the combination of docetaxel and kaempferol has a synergistic effect in inhibiting prostate cancer cell proliferation and works by inducing autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Bo Yuan, Kang Xu, Ryota Shimada, JingZhe Li, Hideki Hayashi, Mari Okazaki, Norio Takagi
Summary: Glioblastoma is a fatal primary malignant brain tumor with a low survival rate, and there is an urgent need for novel therapeutic approaches. Trivalent arsenic derivative and gamabufotalin show cytotoxic effects against glioblastoma cells, with synergistic cytotoxicity when combined. The study suggests that G(2)/M cell cycle arrest, necrosis, and autophagy contribute to the cytotoxicity, and a possible strategy of combining these compounds with a p38 MAPK inhibitor may provide new insights into combating glioblastoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Monika Joshi, Sheldon L. Holder, Junjia Zhu, Hong Zheng, Shraddha Komanduri, Joshua Warrick, Hesham Yasin, Rohan Garje, Bei Jia, Joseph J. Drabick, David J. DeGraff, Yousef Zakharia
Summary: This study evaluated the safety and efficacy of eribulin mesylate in combination with avelumab for the treatment of mUC. Although the study was terminated early, it was observed that lower doses of eribulin were better tolerated and had an anti-cancer effect. Further research is needed.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Oncology
Silvia Matteoni, Paola Matarrese, Barbara Ascione, Lucia Ricci-Vitiani, Roberto Pallini, Veronica Villani, Andrea Pace, Marco G. Paggi, Claudia Abbruzzese
Summary: The study demonstrates that chlorpromazine (CPZ) hinders malignant features of glioblastoma (GBM) cells by perturbing endoplasmic reticulum (ER) stress and inducing an intense autophagic response. This cytotoxic effect is selective for GBM cells while being cytoprotective for normal cells, suggesting a potential novel treatment approach for GBM patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Mansi Arora, James M. Bogenberger, Amro M. Abdelrahman, Jennifer Yonkus, Roberto Alva-Ruiz, Jennifer L. Leiting, Xianfeng Chen, Pedro Luiz Serrano Uson, Chelsae R. Dumbauld, Alexander T. Baker, Scott Gamb, Jan B. Egan, Yumei Zhou, Bolni Marius Nagalo, Nathalie Meurice, Eeva-Liisa Eskelinen, Marcela A. Salomao, Heidi E. Kosiorek, Esteban Braggio, Michael T. Barrett, Kenneth H. Buetow, Mohamad B. Sonbol, Aaron S. Mansfield, Lewis R. Roberts, Tanios S. Bekaii-Saab, Daniel H. Ahn, Mark J. Truty, Mitesh J. Borad
Summary: The combination of gemcitabine/cisplatin and CDK4/6 inhibitors showed enhanced efficacy, reduced toxicity, and better survival in BTC models. Monotherapy with abemaciclib had modest efficacy due to autophagy-induced resistance, but triplet therapy was able to potentiate efficacy through elimination of the autophagic flux. Abemaciclib also potentiated sensitization to gemcitabine through reduction of ribonucleotide reductase catalytic subunit M1.
Article
Multidisciplinary Sciences
Kuei-Yen Tsai, Po-Li Wei, Mohamed Azarkan, Nasiha M'Rabet, Precious Takondwa Makondi, Hsin-An Chen, Chien-Yu Huang, Yu-Jia Chang
Summary: This study found that F3 bromelain can inhibit the proliferation of colorectal cancer cells, and has comparable cytotoxicity to unfractionated bromelain. F3 bromelain can also be used in combination with routine chemotherapeutic agents to increase cytotoxicity in colorectal cancer cells.
Article
Oncology
Se Hyun Kim, Seock-Ah Im, Koung Jin Suh, Kyung-Hun Lee, Min Hwan Kim, Joohyuk Sohn, Yeon Hee Park, Ji-Yeon Kim, Jae Ho Jeong, Kyoung Eun Lee, In Sil Choi, Kyong Hwa Park, Hee-Jun Kim, Eun Kyung Cho, So Yeon Park, Milim Kim, Jee Hyun Kim
Summary: This study evaluated the efficacy and safety of nivolumab and eribulin combination therapy for metastatic breast cancer in Asian populations. The results showed that this combination therapy had relatively good efficacy and tolerable safety in patients with hormone receptor-positive/HER2-negative and triple-negative breast cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Food Science & Technology
Hsin-Ling Yang, Chia-Hsuan Tsai, Sirjana Shrestha, Chuan-Chen Lee, Jiunn-Wang Liao, You-Cheng Hseu
Summary: The study demonstrated that Coenzyme Q(0) has anticancer activities against human glioblastoma by inducing apoptosis and autophagy, inhibiting tumor cell growth and formation. Additionally, inhibiting the pathways of cell apoptosis and autophagy can affect the anticancer properties of Coenzyme Q(0).
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Veterinary Sciences
Yaocheng Cui, Hongrui Guo, Qin Zhang, Jing Fang, Yue Xie, Shiyi Chen, Xiaoping Ma, Liping Gou, Hengmin Cui, Yi Geng, Gang Ye, Zhijun Zhong, Zhihua Ren, Ya Wang, Junliang Deng, Shuming Yu, Suizhong Cao, Zhisheng Wang, Zhicai Zuo
Summary: The combined effect of high glucose and lipopolysaccharide decreased cell viability and induced autophagy in MDBK cells, with Notch3/mTOR signaling pathway involved in the process.
BMC VETERINARY RESEARCH
(2022)
Article
Oncology
Jossimar Coronel-Hernandez, Rebeca Salgado-Garcia, David Cantu-De Leon, Nadia Jacobo-Herrera, Oliver Millan-Catalan, Izamary Delgado-Waldo, Alma D. Campos-Parra, Miguel Rodriguez-Morales, Norma L. Delgado-Buenrostro, Carlos Perez-Plasencia
Summary: A combination therapy using doxorubicin, metformin, and sodium oxamate was implemented to treat colorectal cancer, revealing a potential autophagy regulation mechanism mediated by microRNAs and exploring the transcriptional regulation mechanism of this treatment combination.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Anna A. Kiseleva, Erica A. Golemis
Review
Oncology
Robert Clarke, Pavel Kraikivski, Brandon C. Jones, Catherine M. Sevigny, Surojeet Sengupta, Yue Wang
CANCER AND METASTASIS REVIEWS
(2020)
Article
Developmental Biology
Kelvin See, Anna A. Kiseleva, Cheryl L. Smith, Feiyan Liu, Jun Li, Andrey Poleshko, Jonathan A. Epstein
DEVELOPMENTAL BIOLOGY
(2020)
Article
Oncology
Alexander Y. Deneka, Meghan C. Kopp, Anna S. Nikonova, Anna Gaponova, Anna A. Kiseleva, Harvey H. Hensley, Douglas B. Flieder, Ilya G. Serebriiskii, Erica A. Golemis
Summary: This study reveals a new role for the scaffolding protein NEDD9 in regulating LKB1-AMPK signaling in early stage NSCLC, suppressing autophagy and tumor growth.
Article
Oncology
Bora Lim, David A. Potter, Mohamad A. Salkeni, Paula Silverman, Tufia C. Haddad, Frederic Forget, Ahmad Awada, Jean-Luc Canon, Michael Danso, Alain Lortholary, Hugues Bourgeois, Elizabeth Tan-Chiu, Sylvie Vincent, Brittany Bahamon, Kevin J. Galinsky, Chirag Patel, Rachel Neuwirth, E. Jane Leonard, Jennifer R. Diamond
Summary: The study evaluated the efficacy and safety of sapanisertib plus exemestane or fulvestrant in treating advanced/metastatic hormone receptor-positive breast cancer, showing certain clinical benefit for patients. The treatment demonstrated different efficacy in patients previously sensitive or resistant to exemestane.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kristina M. Whately, Maria A. Voronkova, Abha Maskey, Jasleen Gandhi, Juergen Loskutov, Hyeran Choi, Sila Yanardag, Dongquan Chen, Sijin Wen, Naira Margaryan, Matthew B. Smolkin, Marc L. Purazo, Gangqing Hu, Elena N. Pugacheva
Summary: Metastatic breast cancer, especially in triple negative breast cancers, is a leading cause of breast cancer-related deaths. The presence of nuclear AURKA is molecularly connected to metastatic dissemination through HIF1 signaling, and it has been identified as a crucial driver of early metastasis. The expression of multiple HIF-dependent genes induced by nuclear AURKA promotes early cancer dissemination and is associated with decreased patient survival.
Review
Oncology
Mohamad Adham Salkeni, Wajeeha Rizvi, Kyaw Hein, Gerald M. Higa
Summary: The discovery of HER2 has had profound implications for breast cancer, leading to significant advances in understanding the disease at a molecular level and providing avenues for target-specific therapies. Despite its predictive and prognostic value, challenges remain in treating tumor recurrence and metastatic disease, suggesting a need for further research on reprogrammable signaling pathways.
BREAST CANCER-TARGETS AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Naomi G. Williamson, Callee M. Walsh, Teiya Kijimoto
Summary: Organisms can alter their phenotypes in response to changing environmental conditions, a phenomenon known as phenotypic plasticity. In this study, using dung beetles as a model organism, researchers explored the physiological basis of phenotypic plasticity and found that differences in metabolite levels were more apparent between animals with different body sizes than between different sexes. They also identified specific metabolites and biochemical pathways that may be involved in horn size determination.
Article
Public, Environmental & Occupational Health
Callee M. Walsh, Stephen R. Jackson, Notashia N. Baughman, Jason E. Ham, J. R. Wells
Summary: In this study, a personal sampling technique was developed to quantify the concentration of peracetic acid in air samples. The technique demonstrated high specificity and accuracy, and it allowed for longer sampling periods compared to current methods. The use of safer personal sampling materials adds to the utility of this technique.
ACS CHEMICAL HEALTH & SAFETY
(2022)
Article
Multidisciplinary Sciences
Fatimah Matalkah, Scott Rhodes, Visvanathan Ramamurthy, Peter Stoilov
Summary: The study identified a structural epitope of PROM1 recognized by mAB 13A4 and demonstrated significant differences in affinity between mAB 13A4 and the PROM1 isoforms in photoreceptor cells. The results support the computationally predicted helical bundle structure of PROM1 and highlight the usefulness of mAB 13A4 in evaluating the impact of mutations on PROM1 structure.
Article
Biology
Fatimah Matalkah, Bohye Jeong, Macie Sheridan, Eric Horstick, Visvanathan Ramamurthy, Peter Stoilov
Summary: RNA-binding proteins Musashi 1 and 2 play important roles in the survival and function of photoreceptor cells, regulating splicing and protein expression. Their roles in stem cells are opposite to their roles in mature photoreceptor cells, but they are still essential.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Anna A. Kiseleva, Yu-Chia Cheng, Cheryl L. Smith, Richard A. Katz, Andrey Poleshko
Summary: This study demonstrates that Proline Rich 14 (PRR14) protein organizes H3K9me3-modified heterochromatin at the nuclear lamina. It is shown that PRR14 associates with both the nuclear lamina and heterochromatin, and can reorganize heterochromatin in interphase cells independently of mitosis. The study proposes a model of dynamic heterochromatin organization at the nuclear lamina via the PRR14 tethering protein.
Review
Oncology
Robert Clarke, Brandon C. Jones, Catherine M. Sevigny, Leena A. Hilakivi-Clarke, Surojeet Sengupta
Summary: Despite the relatively limited number of experimental models of ER+ breast cancer, they have been proven to be very useful in advancing understanding of how cells respond to endocrine therapies and the role of ER as a transcription factor. These models, despite their limitations, play a crucial role in studying mechanisms of therapy action and resistance and hypothesis testing in breast cancer research.
CANCER DRUG RESISTANCE
(2021)
Article
Biochemistry & Molecular Biology
Jesse Sundar, Fatimah Matalkah, Bohye Jeong, Peter Stoilov, Visvanathan Ramamurthy
Summary: The Musashi family of RNA-binding proteins plays a critical role in the morphogenesis of terminally differentiated photoreceptor neurons in the retina. Loss of MSI1 and MSI2 in mice led to disrupted photoreceptor outer segment morphology and eventually neuronal degeneration, highlighting the importance of Musashi proteins in regulating key transcripts critical for photoreceptor function.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Meeting Abstract
Oncology
S. Sengupta, C. M. Sevigny, B. C. Jones, L. Jin, P. R. Pohlmann, R. Calrke