The Fab Conformations in the Solution Structure of Human Immunoglobulin G4 (IgG4) Restrict Access to Its Fc Region

Structural Determinants of Unique Properties of Human IgG4-Fc

(2013) Anna M. Davies et al.   JOURNAL OF MOLECULAR BIOLOGY

The Solution Structure of Rabbit IgG Accounts for Its Interactions with the Fc Receptor and Complement C1q and Its Conformational Stability

(2012) Lucy E. Rayner et al.   JOURNAL OF MOLECULAR BIOLOGY

Atomic resolution model of the antibody Fc interaction with the complement C1q component

(2012) Sebastian Schneider et al.   MOLECULAR IMMUNOLOGY

Crystal structure of the human IgG4 CH3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange

(2012) Anna M. Davies et al.   MOLECULAR IMMUNOLOGY

Crystal Structure of Fcγ Receptor I and Its Implication in High Affinity γ-Immunoglobulin Binding

(2011) Jinghua Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3-CH3 Interaction Strength

(2011) A. F. Labrijn et al.   JOURNAL OF IMMUNOLOGY

Mechanism of Immunoglobulin G4 Fab-arm Exchange

(2011) Theo Rispens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

(2011) Rebecca J. Rose et al.   STRUCTURE

Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy

(2010) Yuki Abe et al.   BIOCHEMICAL JOURNAL

Potential aggregation prone regions in biotherapeutics

(2010) Xiaoling Wang et al.   mAbs

Hybrid IgG4/IgG4 Fc antibodies form upon ‘Fab-arm’ exchange as demonstrated by SDS-PAGE or size-exclusion chromatography

(2010) Theo Rispens et al.   MOLECULAR IMMUNOLOGY

Intrachain disulfide bond in the core hinge region of human IgG4

(2010) James W. Bloom et al.   PROTEIN SCIENCE

Immunoglobulin G4: an odd antibody

(2009) R. C. Aalberse et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Human IgG4 Binds to IgG4 and Conformationally Altered IgG1 via Fc-Fc Interactions

(2009) T. Rispens et al.   JOURNAL OF IMMUNOLOGY

Constrained solution scattering modelling of human antibodies and complement proteins reveals novel biological insights

(2009) S. J. Perkins et al.   Journal of the Royal Society Interface

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

(2009) Aran F Labrijn et al.   NATURE BIOTECHNOLOGY

Structure determinations of human and chimaeric antibodies by solution scattering and constrained molecular modelling

(2008) Stephen J. Perkins et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

The Effect of a Point Mutation on the Stability of IgG4 as Monitored by Analytical Ultracentrifugation

(2007) Yanling Lu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES