Pharmacologic inhibition of hypoxia‐inducible factor (HIF)‐hydroxylases ameliorates allergic contact dermatitis

Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling

(2016) Mario C. Manresa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD

(2016) R. Provenzano et al.   Clinical Journal of the American Society of Nephrology

E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity

(2015) Jee H. Lee et al.   IMMUNITY

Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients

(2015) A. Besarab et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection

(2014) Kelly M. Shepardson et al.   PLoS Pathogens

A dynamic model of the hypoxia-inducible factor 1  (HIF-1 ) network

(2013) L. K. Nguyen et al.   JOURNAL OF CELL SCIENCE

Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn’s disease/infectious colitis and healthy controls

(2013) Sophie Van Welden et al.   Journal of Inflammation-London

Regulation of IL-1 -induced NF- B by hydroxylases links key hypoxic and inflammatory signaling pathways

(2013) C. C. Scholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Expression of Fas Ligand and Perforin Directs Effector CD8 T Cell Infiltration into Antigen-Challenged Skin

(2012) D. D. Kish et al.   JOURNAL OF IMMUNOLOGY

Glutamine Suppresses DNFB-Induced Contact Dermatitis by Deactivating p38 Mitogen–Activated Protein Kinase via Induction of MAPK Phosphatase-1

(2012) Otgonzaya Ayush et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Invariant NKT Cells Suppress CD8+ T-Cell–Mediated Allergic Contact Dermatitis Independently of Regulatory CD4+ T Cells

(2012) Anne Goubier et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Update of Immune Events in the Murine Contact Hypersensitivity Model: Toward the Understanding of Allergic Contact Dermatitis

(2012) Tetsuya Honda et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The role of neutrophils during intestinal inflammation

(2012) B M Fournier et al.   Mucosal Immunology

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of chemical-induced innate immunity in allergic contact dermatitis

(2011) S. F. Martin et al.   ALLERGY

Chemotherapy Induces Intratumoral Expression of Chemokines in Cutaneous Melanoma, Favoring T-cell Infiltration and Tumor Control

(2011) M. Hong et al.   CANCER RESEARCH

Lack of effect of ustekinumab in treatment of allergic contact dermatitis

(2011) Nannie Bangsgaard et al.   CONTACT DERMATITIS

Immunotherapy of allergic contact dermatitis

(2011) Radoslaw Spiewak   Immunotherapy

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

(2011) Sarah R. Walmsley et al.   JOURNAL OF CLINICAL INVESTIGATION

Hapten Application to the Skin Induces an Inflammatory Program Directing Hapten-Primed Effector CD8 T Cell Interaction with Hapten-Presenting Endothelial Cells

(2011) D. D. Kish et al.   JOURNAL OF IMMUNOLOGY

Pharmacological Characterization of 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid (JNJ-42041935), a Potent and Selective Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor

(2011) T. D. Barrett et al.   MOLECULAR PHARMACOLOGY

Hypoxia inducible factor-1α contributes to UV radiation-induced inflammation, epidermal hyperplasia and immunosuppression in mice

(2011) Jun-Lae Cho et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

The Chemokine Receptor CXCR2 Ligand KC (CXCL1) Mediates Neutrophil Recruitment and Is Critical for Development of Experimental Lyme Arthritis and Carditis

(2010) A. M. Ritzman et al.   INFECTION AND IMMUNITY

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

An Intact Canonical NF- B Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia

(2010) S. F. Fitzpatrick et al.   JOURNAL OF IMMUNOLOGY

Hydroxylase Inhibition Abrogates TNF- -Induced Intestinal Epithelial Damage by Hypoxia-Inducible Factor-1-Dependent Repression of FADD

(2010) P. Hindryckx et al.   JOURNAL OF IMMUNOLOGY

Epithelial decision makers: in search of the 'epimmunome'

(2010) Mahima Swamy et al.   NATURE IMMUNOLOGY

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

Therapeutic Efficacy and Immunological Response of CCL5 Antagonists in Models of Contact Skin Reaction

(2010) Miriam Canavese et al.   PLoS One

Endothelin-1 Inhibits Prolyl Hydroxylase Domain 2 to Activate Hypoxia-Inducible Factor-1α in Melanoma Cells

(2010) Francesca Spinella et al.   PLoS One

Effector and regulatory mechanisms in allergic contact dermatitis

(2009) M. Vocanson et al.   ALLERGY

Prostaglandin E2–EP3 signaling suppresses skin inflammation in murine contact hypersensitivity

(2009) Tetsuya Honda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cutaneous Hypersensitivities to Hapten Are Controlled by IFN-γ-Upregulated Keratinocyte Th1 Chemokines and IFN-γ-Downregulated Langerhans Cell Th2 Chemokines

(2008) Tomoko Mori et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Blockade of the chemokine receptor CXCR2 ameliorates adjuvant-induced arthritis in rats

(2007) M M Barsante et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY