Evolution Meets Disease: Penetrance and Functional Epistasis of Mitochondrial tRNA Mutations

Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness

(2010) Margarita V. Meer et al.   NATURE

The genetic and metabolic signature of oncocytic transformation implicates HIF1α destabilization

(2009) Anna Maria Porcelli et al.   HUMAN MOLECULAR GENETICS

The A3243G tRNALeu(UUR) MELAS mutation causes amino acid misincorporation and a combined respiratory chain assembly defect partially suppressed by overexpression of EFTu and EFG2

(2008) F. Sasarman et al.   HUMAN MOLECULAR GENETICS

Overexpression of human mitochondrial valyl tRNA synthetase can partially restore levels of cognate mt-tRNAVal carrying the pathogenic C25U mutation

(2008) Joanna Rorbach et al.   NUCLEIC ACIDS RESEARCH

Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation

(2008) Tao Sun et al.   NUCLEIC ACIDS RESEARCH

Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNALeu(UUR) gene

(2008) H. Park et al.   RNA