Microglial nodules provide the environment for pathogenic T cells in human encephalitis

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Both IRF3 and especially IRF7 play a key role to orchestrate an effective cerebral inflammatory response in a mouse model of herpes simplex virus encephalitis

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Systematic evaluation of RNA quality, microarray data reliability and pathway analysis in fresh, fresh frozen and formalin-fixed paraffin-embedded tissue samples

(2018) Isabella Wimmer et al.   Scientific Reports

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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The Reactome Pathway Knowledgebase

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The Role of Interferons in Inflammation and Inflammasome Activation

(2017) Nataša Kopitar-Jerala   Frontiers in Immunology

Differences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis

(2016) Susanne Laukoter et al.   ACTA NEUROPATHOLOGICA

Clinical perspectives of TRAIL: insights into central nervous system disorders

(2016) Veronica Tisato et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself

(2016) Saskia Maria Burm et al.   Journal of Neuroinflammation

Toll-like receptors and chronic inflammation in rheumatic diseases: new developments

(2016) Leo A. B. Joosten et al.   Nature Reviews Rheumatology

CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing

(2016) Tilman Schneider-Hohendorf et al.   Nature Communications

“Microglial nodules” and “newly forming lesions” may be a Janus face of early MS lesions; implications from virus-induced demyelination, the Inside-Out model

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Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system

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Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances

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Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons

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Neuroprotective intervention by interferon-γ blockade prevents CD8+T cell–mediated dendrite and synapse loss

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Differential expression of interferon-γ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune response

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Inflammasome induction in Rasmussen’s encephalitis: cortical and associated white matter pathogenesis

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Alpha-B-Crystallin Induces an Immune-Regulatory and Antiviral Microglial Response in Preactive Multiple Sclerosis Lesions

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Identification of a unique TGF-β–dependent molecular and functional signature in microglia

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The Reactome pathway knowledgebase

(2013) David Croft et al.   NUCLEIC ACIDS RESEARCH

Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection

(2013) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

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An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

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Progressive multiple sclerosis: pathology and pathogenesis

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The role of inflammation in epileptogenesis

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Anti-viral CD8 T cells and the cytokines that they love

(2012) Maureen A. Cox et al.   VIROLOGY

Regulation of interleukin-1β by interferon-γ is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production

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TLR-signaling Networks

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Interleukin 18 in the CNS

(2010) Silvia Alboni et al.   Journal of Neuroinflammation

αB-Crystallin Is a Target for Adaptive Immune Responses and a Trigger of Innate Responses in Preactive Multiple Sclerosis Lesions

(2010) Johannes M. van Noort et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Preactive lesions in multiple sclerosis

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

After Injection into the Striatum, in Vitro-Differentiated Microglia- and Bone Marrow-Derived Dendritic Cells Can Leave the Central Nervous System via the Blood Stream

(2008) Sonja Hochmeister et al.   AMERICAN JOURNAL OF PATHOLOGY

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

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Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

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