Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells
Authors
Keywords
-
Journal
CELL CYCLE
Volume 11, Issue 5, Pages 974-989
Publisher
Informa UK Limited
Online
2012-03-07
DOI
10.4161/cc.11.5.19450
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer
- (2016) Javier A. Menendez et al. Aging-US
- Metformin: Multi-faceted protection against cancer
- (2015) Sonia Del Barco et al. Oncotarget
- Sensing of energy and nutrients by AMP-activated protein kinase
- (2011) D Grahame Hardie AMERICAN JOURNAL OF CLINICAL NUTRITION
- Energy metabolism in nuclear reprogramming
- (2011) Clifford DL Folmes et al. Biomarkers in Medicine
- Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
- (2011) D. Iliopoulos et al. CANCER RESEARCH
- The Lin28/let-7 Axis Regulates Glucose Metabolism
- (2011) Hao Zhu et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression
- (2011) Marcus E. Peter CELL CYCLE
- Metformin activates an Ataxia Telangiectasia Mutated (ATM)/Chk2-regulated DNA damage-like response
- (2011) Alejandro Vazquez-Martin et al. CELL CYCLE
- Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a
- (2011) Cristina Oliveras-Ferraros et al. CELL CYCLE
- mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: A roadmap from energy metabolism to stem cell renewal and aging
- (2011) Javier A. Menendez et al. CELL CYCLE
- Anaerobicizing into Pluripotency
- (2011) Athanasia D. Panopoulos et al. Cell Metabolism
- Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming
- (2011) Clifford D.L. Folmes et al. Cell Metabolism
- Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape
- (2011) Bernadett Papp et al. CELL RESEARCH
- Inducing iPSCs to Escape the Dish
- (2011) Bonnie Barrilleaux et al. Cell Stem Cell
- Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth
- (2011) G. Z. Rocha et al. CLINICAL CANCER RESEARCH
- Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
- (2011) X. Stephenne et al. DIABETOLOGIA
- Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions
- (2011) Alejandro Vazquez-Martin et al. DRUG RESISTANCE UPDATES
- Small RNA-mediated regulation of iPS cell generation
- (2011) Zhonghan Li et al. EMBO JOURNAL
- AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function
- (2011) D. G. Hardie GENES & DEVELOPMENT
- Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells
- (2011) Alessandro Prigione et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
- Inhibition of Glycolytic Enzymes Mediated by Pharmacologically Activated p53
- (2011) Joanna Zawacka-Pankau et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oncogene-Induced Senescence and its Role in Tumor Suppression
- (2011) Jay P. Reddy et al. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- Integrated Analysis of ATM Mediated Gene and Protein Expression Impacting Cellular Metabolism
- (2011) Amrita K. Cheema et al. JOURNAL OF PROTEOME RESEARCH
- Metformin may antagonize Lin28 and/or Lin28B activity, thereby boosting let-7 levels and antagonizing cancer progression
- (2011) Mark F. McCarty MEDICAL HYPOTHESES
- Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
- (2011) Momoko Maekawa et al. NATURE
- The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
- (2011) Maria M. Mihaylova et al. NATURE CELL BIOLOGY
- p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
- (2011) Peng Jiang et al. NATURE CELL BIOLOGY
- Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts
- (2011) Sandra Varum et al. PLoS One
- Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression
- (2011) Ji-Won Jung et al. PLoS One
- Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs
- (2011) R. J. A. Frost et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Embryonic Stem Cell MicroRNAs: Defining Factors in Induced Pluripotent (iPS) and Cancer (CSC) Stem Cells?
- (2011) Preethi Gunaratne Current Stem Cell Research & Therapy
- The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells
- (2010) Alejandro Vazquez-Martin et al. BREAST CANCER RESEARCH AND TREATMENT
- Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
- (2010) M. Pollak Cancer Prevention Research
- Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism
- (2010) C. V. Dang CANCER RESEARCH
- AMPK: Evidence for an energy-sensing cytokinetic tumor suppressor
- (2010) Alejandro Vazquez-Martin et al. CELL CYCLE
- Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): From cancer stem cells to aging-associated fibrosis
- (2010) Sílvia Cufí et al. CELL CYCLE
- p53: Guardian of reprogramming
- (2010) Sergio Menendez et al. CELL CYCLE
- Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status
- (2010) Alejandro Vazquez-Martin et al. CELL CYCLE
- Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
- (2010) Simon A. Hawley et al. Cell Metabolism
- Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells
- (2010) Miguel Angel Esteban et al. Cell Stem Cell
- Metformin and Energy Metabolism in Breast Cancer: From Insulin Physiology to Tumour-initiating Stem Cells
- (2010) A. Vazquez-Martin et al. CURRENT MOLECULAR MEDICINE
- Induced pluripotent stem cells and senescence: learning the biology to improve the technology
- (2010) Ana Banito et al. EMBO REPORTS
- Metformin: Taking away the candy for cancer?
- (2010) Mathilde Jalving et al. EUROPEAN JOURNAL OF CANCER
- AMPK as a metabolic tumor suppressor: control of metabolism and cell growth
- (2010) Zhijun Luo et al. Future Oncology
- Induced pluripotency: history, mechanisms, and applications
- (2010) M. Stadtfeld et al. GENES & DEVELOPMENT
- An energetic tale of AMPK-independent effects of metformin
- (2010) Russell A. Miller et al. JOURNAL OF CLINICAL INVESTIGATION
- Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
- (2010) Marc Foretz et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting Breast Cancer Stem Cells
- (2010) Suling Liu et al. JOURNAL OF CLINICAL ONCOLOGY
- p53 connects tumorigenesis and reprogramming to pluripotency: Figure 1.
- (2010) Natalia Tapia et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?
- (2010) I. Ben Sahra et al. MOLECULAR CANCER THERAPEUTICS
- Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
- (2010) Collin Melton et al. NATURE
- Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies
- (2010) Hao Zhu et al. NATURE GENETICS
- Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer
- (2010) S Peng et al. ONCOGENE
- The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells
- (2010) Alessandro Prigione et al. STEM CELLS
- AMP-activated protein kinase activator A-769662 is an inhibitor of the Na+-K+-ATPase
- (2009) Boubacar Benziane et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
- (2009) S. Fogarty et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission
- (2009) H. A. Hirsch et al. CANCER RESEARCH
- The role of p53 in limiting somatic cell reprogramming
- (2009) Yan Liu et al. CELL RESEARCH
- Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells
- (2009) Yoshinori Yoshida et al. Cell Stem Cell
- Mouse Fibroblasts Lacking RB1 Function Form Spheres and Undergo Reprogramming to a Cancer Stem Cell Phenotype
- (2009) Yongqing Liu et al. Cell Stem Cell
- Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins
- (2009) Hongyan Zhou et al. Cell Stem Cell
- MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
- (2009) C. V. Dang et al. CLINICAL CANCER RESEARCH
- The role of let-7 in cell differentiation and cancer
- (2009) Benjamin Boyerinas et al. ENDOCRINE-RELATED CANCER
- Senescence impairs successful reprogramming to pluripotent stem cells
- (2009) A. Banito et al. GENES & DEVELOPMENT
- Tumor suppressors and cell metabolism: a recipe for cancer growth
- (2009) R. G. Jones et al. GENES & DEVELOPMENT
- The promises and perils of p53
- (2009) Valery Krizhanovsky et al. NATURE
- Linking the p53 tumour suppressor pathway to somatic cell reprogramming
- (2009) Teruhisa Kawamura et al. NATURE
- A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
- (2009) Rosa M. Marión et al. NATURE
- Direct cell reprogramming is a stochastic process amenable to acceleration
- (2009) Jacob Hanna et al. NATURE
- Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
- (2009) Hyenjong Hong et al. NATURE
- Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
- (2009) Jochen Utikal et al. NATURE
- The Ink4/Arf locus is a barrier for iPS cell reprogramming
- (2009) Han Li et al. NATURE
- Lin28 promotes transformation and is associated with advanced human malignancies
- (2009) Srinivas R Viswanathan et al. NATURE GENETICS
- Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells
- (2009) Caihong Qiu et al. NUCLEIC ACIDS RESEARCH
- c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry
- (2009) F Morrish et al. ONCOGENE
- mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
- (2009) D. B. Shackelford et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation
- (2009) E. P. Papapetrou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Deconstructing Stem Cell Tumorigenicity: A Roadmap to Safe Regenerative Medicine
- (2009) Paul S. Knoepfler STEM CELLS
- Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
- (2008) Xu Huang et al. BIOCHEMICAL JOURNAL
- Participation of OCT3/4 and β-catenin during dysgenetic gonadal malignant transformation
- (2008) Icela Palma et al. CANCER LETTERS
- Octamer 4 Small Interfering RNA Results in Cancer Stem Cell-Like Cell Apoptosis
- (2008) T. Hu et al. CANCER RESEARCH
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
- Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail
- (2008) Paul S. Knoepfler Cell Stem Cell
- Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells
- (2008) David J. Wong et al. Cell Stem Cell
- Guidelines and Techniques for the Generation of Induced Pluripotent Stem Cells
- (2008) Nimet Maherali et al. Cell Stem Cell
- Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma
- (2008) S.-H. Chiou et al. CLINICAL CANCER RESEARCH
- Cellular life span and the Warburg effect
- (2008) Hiroshi Kondoh EXPERIMENTAL CELL RESEARCH
- Myc's broad reach
- (2008) M. Eilers et al. GENES & DEVELOPMENT
- Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)
- (2008) Hua Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Molecular Mechanism Governing the Oncogenic Potential of SOX2 in Breast Cancer
- (2008) Yupeng Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Implications of the Cancer Stem-Cell Hypothesis for Breast Cancer Prevention and Therapy
- (2008) Madhuri Kakarala et al. JOURNAL OF CLINICAL ONCOLOGY
- p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
- (2008) Hongwu Zheng et al. NATURE
- Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
- (2008) Danwei Huangfu et al. NATURE BIOTECHNOLOGY
- Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
- (2008) Danwei Huangfu et al. NATURE BIOTECHNOLOGY
- An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors
- (2008) Ittai Ben-Porath et al. NATURE GENETICS
- Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
- (2008) K. Okita et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started