The Role of Autophagy in Crohn’s Disease

Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease

(2016) Lynn Cotterill et al.   CANADIAN JOURNAL OF GASTROENTEROLOGY

Dynamics and function of PtdIns(3)Pin autophagy

(2014) Keisuke Obara et al.   Autophagy

The incredible ULKs

(2012) Sebastian Alers et al.   Cell Communication and Signaling

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response

(2012) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

Immuno-inhibitory PD-L1 can be induced by a Peptidoglycan/NOD2 mediated pathway in primary monocytic cells and is deficient in Crohn's patients with homozygous NOD2 mutations.

(2012) Rachel E. Hewitt et al.   CLINICAL IMMUNOLOGY

Mechanisms of LRRK2-Mediated Neurodegeneration

(2012) Elpida Tsika et al.   Current Neurology and Neuroscience Reports

Mutations in IRGM Are Associated With More Frequent Need for Surgery in Patients With Ileocolonic Crohnʼs Disease

(2012) Rishabh Sehgal et al.   DISEASES OF THE COLON & RECTUM

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

(2012) Adriana Sánchez-Danés et al.   EMBO Molecular Medicine

Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse

(2012) Manon E. Wildenberg et al.   GASTROENTEROLOGY

Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans

(2012) Deepa Raju et al.   GASTROENTEROLOGY

OC-010 Detailed analysis of ATG16L1 demonstrates gene-wide extent of association with crohn's disease susceptibility

(2012) J Van Limbergen et al.   GUT

Hospitalisations and surgery in Crohn's disease

(2012) Charles N Bernstein et al.   GUT

The intermediate filament protein, vimentin, is a regulator of NOD2 activity

(2012) Craig Stevens et al.   GUT

Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohnʼs disease

(2012) Travis B. Murdoch et al.   INFLAMMATORY BOWEL DISEASES

Associations Between Genetic Variants in the IRGM Gene and Inflammatory Bowel Diseases in the Korean Population

(2012) Chang Mo Moon et al.   INFLAMMATORY BOWEL DISEASES

Phenotype–Genotype Profiles in Crohnʼs Disease Predicted by Genetic Markers in Autophagy-Related Genes (GOIA Study II)

(2012) Cecília Durães et al.   INFLAMMATORY BOWEL DISEASES

A Dual Role for Receptor-interacting Protein Kinase 2 (RIP2) Kinase Activity in Nucleotide-binding Oligomerization Domain 2 (NOD2)-dependent Autophagy

(2012) Craig R. Homer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IBD—what role do Proteobacteria play?

(2012) Indrani Mukhopadhya et al.   Nature Reviews Gastroenterology & Hepatology

Association Analysis ofULK1with Crohn’s Disease in a New Zealand Population

(2012) Angharad R. Morgan et al.   Gastroenterology Research and Practice

Antigen Processing for MHC Class II Presentation via Autophagy

(2012) Christian Münz   Frontiers in Immunology

Clinical and Genetic Risk Factors for Perianal Crohn's Disease in a Population-Based Cohort

(2011) T W Eglinton et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Biogenesis and Cargo Selectivity of Autophagosomes

(2011) Hilla Weidberg et al.   Annual Review of Biochemistry

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway

(2011) Marija Cemma et al.   Autophagy

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

(2011) Trond Lamark et al.   CELL CYCLE

Autophagy: for better or for worse

(2011) Ellen Wirawan et al.   CELL RESEARCH

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Analysis of Escherichia coli Isolated from Patients Affected by Crohn’s Disease

(2011) Tiziana Raso et al.   CURRENT MICROBIOLOGY

Ubiquitination-mediated autophagy against invading bacteria

(2011) Naonobu Fujita et al.   CURRENT OPINION IN CELL BIOLOGY

NOD-like receptors and the innate immune system: Coping with danger, damage and death

(2011) Kristof Kersse et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Meta-analysis of the Role of Granulomas in the Recurrence of Crohn Disease

(2011) Constantinos Simillis et al.   DISEASES OF THE COLON & RECTUM

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease: Figure 1

(2011) R Somasundaram et al.   GUT

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2

(2011) T. S. Plantinga et al.   GUT

NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant inNCF2that results in reduced binding to RAC2

(2011) Aleixo M Muise et al.   GUT

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

(2011) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response

(2011) Johanneke Kleinnijenhuis et al.   IMMUNOLOGY

NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohnʼs disease in canadian children and young adults

(2011) Devendra K. Amre et al.   INFLAMMATORY BOWEL DISEASES

Protein Tyrosine Phosphatase Nonreceptor Type 2 Regulates Autophagosome Formation in Human Intestinal Cells

(2011) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

Crohnʼs disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy

(2011) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

Characterization of adherent-invasive Escherichia coli isolated from pediatric patients with inflammatory bowel disease

(2011) Anna Negroni et al.   INFLAMMATORY BOWEL DISEASES

Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways

(2011) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crohn disease–associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae

(2011) Benoit Chassaing et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic variants in autophagy-related genes and granuloma formation in a cohort of surgically treated Crohn's disease patients

(2011) Marko Brinar et al.   Journal of Crohns & Colitis

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

(2011) Mansoureh Hakimi et al.   JOURNAL OF NEURAL TRANSMISSION

Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives

(2011) Zelda H. Cheung et al.   JOURNAL OF NEUROCHEMISTRY

Molecular pathogenesis of Parkinson's disease: update

(2011) Shinji Saiki et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Autophagy and disease: always two sides to a problem

(2011) Sunandini Sridhar et al.   JOURNAL OF PATHOLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese

(2011) Zhibin Hu et al.   NATURE GENETICS

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

(2011) Patrick Brest et al.   NATURE GENETICS

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

The role of bacteria and pattern-recognition receptors in Crohn's disease

(2011) Si Ming Man et al.   Nature Reviews Gastroenterology & Hepatology

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

IRGM Is a Common Target of RNA Viruses that Subvert the Autophagy Network

(2011) Isabel Pombo Grégoire et al.   PLoS Pathogens

Susceptibility loci reported in genome-wide association studies are associated with Crohn’s disease in Canadian children

(2010) D. K. AMRE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability

(2010) SANG YONG SONG et al.   APMIS

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

Ubiquitin: Same Molecule, Different Degradation Pathways

(2010) Michael J. Clague et al.   CELL

Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling

(2010) Dong-Min Shin et al.   CELLULAR MICROBIOLOGY

Nod-like receptors: sentinels at host membranes

(2010) Dana J Philpott et al.   CURRENT OPINION IN IMMUNOLOGY

Is there a role for Crohnʼs disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?

(2010) Simone C. Wolfkamp et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

The role of PI3P phosphatases in the regulation of autophagy

(2010) Isabelle Vergne et al.   FEBS LETTERS

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

Protein tyrosine phosphatase N2 regulates TNF -induced signalling and cytokine secretion in human intestinal epithelial cells

(2010) M. Scharl et al.   GUT

Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive Escherichia coli invasion

(2010) N. Rolhion et al.   GUT

Protein Tyrosine Phosphatase non-Receptor Type 2 regulates IFN-γ-induced cytokine signaling in THP-1 monocytes

(2010) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

Genetic variation in the autophagy gene ULK1 and risk of Crohnʼs disease

(2010) Liesbet Henckaerts et al.   INFLAMMATORY BOWEL DISEASES

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases

(2010) Daniel N. Frank et al.   INFLAMMATORY BOWEL DISEASES

Genetics of childhood-onset inflammatory bowel disease

(2010) Paul Henderson et al.   INFLAMMATORY BOWEL DISEASES

Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease

(2010) Shadi Sepehri et al.   INFLAMMATORY BOWEL DISEASES

IL23R, NOD2/CARD15, ATG16L1 and PHOX2B polymorphisms in a group of patients with Crohn's disease and correlation with sub-phenotypes

(2010) Lauriola   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Granulomas in Crohn's disease: Are newly discovered genetic variants involved?

(2010) Yoav Mazor et al.   Journal of Crohns & Colitis

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

The plasma membrane brings autophagosomes to life

(2010) Ana Maria Cuervo   NATURE CELL BIOLOGY

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Complete Genome Sequence of Crohn's Disease-Associated Adherent-Invasive E. coli Strain LF82

(2010) Sylvie Miquel et al.   PLoS One

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis of clathrin-coated vesicles

(2010) Peter S. McPherson   PROTEOMICS

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Human IRGM gene “to be or not to be”

(2010) Cemaletin Bekpen et al.   Seminars in Immunopathology

Modulation of Local PtdIns3P Levels by the PI Phosphatase MTMR3 Regulates Constitutive Autophagy

(2010) Naoko Taguchi-Atarashi et al.   TRAFFIC

NOD2/CARD15,ATG16L1andIL23Rgene polymorphisms and childhood-onset of Crohn’s disease

(2010) Maria Gazouli   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy 16-like 1 rs2241880 G allele is associated with Crohn’s disease in German children

(2009) Martin Lacher et al.   ACTA PAEDIATRICA

rs224136 on Chromosome 10q21.1 and Variants in PHOX2B, NCF4 and FAM92B Are Not Major Genetic Risk Factors for Susceptibility to Crohn's Disease in the German Population

(2009) Jürgen Glas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Confirmation of Multiple Crohn's Disease Susceptibility Loci in a Large Dutch–Belgian Cohort

(2009) Rinse K Weersma et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions

(2009) Elisa Greggio et al.   ASN Neuro

Parkinson disease, LRRK2 and the endocytic-autophagic pathway

(2009) Javier Alegre-Abarrategui et al.   Autophagy

Toll-like receptors in control of immunological autophagy

(2009) M A Delgado et al.   CELL DEATH AND DIFFERENTIATION

Autophagy, Immunity, and Microbial Adaptations

(2009) Vojo Deretic et al.   Cell Host & Microbe

Crohn's disease-associated adherent-invasiveE. coliare selectively favoured by impaired autophagy to replicate intracellularly

(2009) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

Protection of Epithelial Barrier Function by the Crohn's Disease Associated Gene Protein Tyrosine Phosphatase N2

(2009) Michael Scharl et al.   GASTROENTEROLOGY

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

(2009) R J Palomino-Morales et al.   GENES AND IMMUNITY

Germline variants of IRGM in childhood-onset Crohn's disease

(2009) J Van Limbergen et al.   GUT

ATG16L1 T300A polymorphism and Crohn’s disease susceptibility: evidence from 13,022 cases and 17,532 controls

(2009) Hai-Feng Zhang et al.   HUMAN GENETICS

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

(2009) Karen M. Doody et al.   IMMUNOLOGICAL REVIEWS

Contribution of IL23R but not ATG16L1 to Crohnʼs disease susceptibility in Koreans

(2009) Suk-Kyun Yang et al.   INFLAMMATORY BOWEL DISEASES

Detailed Haplotype-Tagging Study of Germline Variation of MUC19 in Inflammatory Bowel Disease

(2009) Anne M. Phillips et al.   INFLAMMATORY BOWEL DISEASES

Analysis of 39 Crohnʼs Disease Risk loci in Swedish Inflammatory Bowel Disease Patients

(2009) Leif Törkvist et al.   INFLAMMATORY BOWEL DISEASES

Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease

(2009) Shinji Higashi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Autophagy: from basic science to clinical application

(2009) J Van Limbergen et al.   Mucosal Immunology

Common variants at five new loci associated with early-onset inflammatory bowel disease

(2009) Marcin Imielinski et al.   NATURE GENETICS

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Molecular mechanisms of Escherichia coli pathogenicity

(2009) Matthew A. Croxen et al.   NATURE REVIEWS MICROBIOLOGY

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATG16L1andIL23RAre Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands

(2008) Rinse K. Weersma et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

ATG16L1 T300A Shows Strong Associations With Disease Subgroups in a Large Australian IBD Population: Further Support for Significant Disease Heterogeneity

(2008) Elizabeth V. Fowler et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Definition of Phenotypic Characteristics of Childhood-Onset Inflammatory Bowel Disease

(2008) Johan Van Limbergen et al.   GASTROENTEROLOGY

Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort

(2008) R L Roberts et al.   GENES AND IMMUNITY

Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae

(2008) Keisuke Obara et al.   GENES TO CELLS

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation

(2008) Takashi Itoh et al.   MOLECULAR BIOLOGY OF THE CELL

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death

(2008) Carl G Feng et al.   NATURE IMMUNOLOGY

Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

(2008) Petric Kuballa et al.   PLoS One

Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohnʼs disease in Northern Europe

(2007) J. Van Limbergen et al.   INFLAMMATORY BOWEL DISEASES