Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors
出版年份 2013 全文链接
标题
Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors
作者
关键词
-
出版物
Cancers
Volume 5, Issue 4, Pages 27-47
出版商
MDPI AG
发表日期
2013-01-16
DOI
10.3390/cancers5010027
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- α5β1 Integrin Ligand PHSRN Induces Invasion and α5 mRNA in Endothelial Cells to Stimulate Angiogenesis
- (2014) Zhao-Zhu Zeng et al. Translational Oncology
- Phase Ib safety and pharmacokinetic study of volociximab, an anti-α5β1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer
- (2012) B. Besse et al. ANNALS OF ONCOLOGY
- Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 2
- (2012) Bénédicte Delouvrié et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 1
- (2012) Bénédicte Delouvrié et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Integrin 5 1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma
- (2012) H. Janouskova et al. CANCER RESEARCH
- ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial–mesenchymal transition of human cancer cells
- (2012) Eun-Hee Nam et al. CARCINOGENESIS
- An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia
- (2012) Longxuan Li et al. EXPERIMENTAL NEUROLOGY
- A novel treatment for glioblastoma: integrin inhibition
- (2012) Marc C Chamberlain et al. Expert Review of Neurotherapeutics
- Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor
- (2012) Masamichi Nagae et al. JOURNAL OF CELL BIOLOGY
- Finding the weakest link – exploring integrin-mediated mechanical molecular pathways
- (2012) Pere Roca-Cusachs et al. JOURNAL OF CELL SCIENCE
- Negative regulators of integrin activity
- (2012) J. Pouwels et al. JOURNAL OF CELL SCIENCE
- Integrin trafficking at a glance
- (2012) R. E. Bridgewater et al. JOURNAL OF CELL SCIENCE
- Integrin bi-directional signaling across the plasma membrane
- (2012) Ping Hu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
- (2012) Moritz Felcht et al. JOURNAL OF CLINICAL INVESTIGATION
- Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin α5β1 and phosphorylating FAK and paxillin
- (2012) Boya Deng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- O(6)-Methylguanine-DNA Methyltransferase Is a Novel Negative Effector of Invasion in Glioblastoma Multiforme
- (2012) M. Chahal et al. MOLECULAR CANCER THERAPEUTICS
- TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function and localization in epithelial cells
- (2012) K Mythreye et al. ONCOGENE
- Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma
- (2012) D Kesanakurti et al. ONCOGENE
- Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF- B network
- (2012) K. M. Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integrins as therapeutic targets
- (2012) Simon L. Goodman et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Regulation of Integrin Activation
- (2011) Chungho Kim et al. Annual Review of Cell and Developmental Biology
- Steroid Receptor Coactivator-1 Upregulates Integrin 5 Expression to Promote Breast Cancer Cell Adhesion and Migration
- (2011) L. Qin et al. CANCER RESEARCH
- Integrin α5β1 controls invasion of human breast carcinoma cells by direct and indirect modulation of MMP-2 collagenase activity
- (2011) Galina Morozevich et al. CELL CYCLE
- Mechanisms of integrin activation and trafficking
- (2011) Coert Margadant et al. CURRENT OPINION IN CELL BIOLOGY
- Volociximab in cancer
- (2011) Salah Almokadem et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer
- (2011) Katherine M. Bell-McGuinn et al. GYNECOLOGIC ONCOLOGY
- Involvement of the TGFβ pathway in the regulation of α5β1 integrins by caveolin-1 in human glioblastoma
- (2011) Erika C. Cosset et al. INTERNATIONAL JOURNAL OF CANCER
- Integrin 5 1 facilitates cancer cell invasion through enhanced contractile forces
- (2011) C. T. Mierke et al. JOURNAL OF CELL SCIENCE
- Alcohol promotes breast cancer cell invasion by regulating the Nm23-ITGA5 pathway
- (2011) Amy W Wong et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Molecular Characterization of the Tumor-Suppressive Function of Nischarin in Breast Cancer
- (2011) Somesh Baranwal et al. JNCI-Journal of the National Cancer Institute
- Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis
- (2011) Yanfang Wang et al. Molecular Cancer
- The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk
- (2011) E Arpaia et al. ONCOGENE
- Suppression of α5 gene expression is closely related to the tumorigenic properties of uveal melanoma cell lines
- (2011) Solange Landreville et al. Pigment Cell & Melanoma Research
- Cancer Cell Invasion Is Enhanced by Applied Mechanical Stimulation
- (2011) Shalini Menon et al. PLoS One
- Integrin Structure, Activation, and Interactions
- (2011) I. D. Campbell et al. Cold Spring Harbor Perspectives in Biology
- Integrin Inhibitors as a Therapeutic Agent for Ovarian Cancer
- (2011) Kenjiro Sawada et al. Journal of Oncology
- α5β1-Integrin Expression Is Essential for Tumor Progression in Experimental Lung Cancer
- (2010) Jesse Roman et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- The PHSCN dendrimer as a more potent inhibitor of human breast cancer cell invasion, extravasation, and lung colony formation
- (2010) Hongren Yao et al. BREAST CANCER RESEARCH AND TREATMENT
- Bcl-2 and β1-integrin predict survival in a tissue microarray of small cell lung cancer
- (2010) M H Lawson et al. BRITISH JOURNAL OF CANCER
- Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression
- (2010) Vermont P. Dia et al. CANCER LETTERS
- Survivin Enhances Motility of Melanoma Cells by Supporting Akt Activation and 5 Integrin Upregulation
- (2010) J. A. McKenzie et al. CANCER RESEARCH
- Kallikrein-Related Peptidase 7 Promotes Multicellular Aggregation via the α5β1Integrin Pathway and Paclitaxel Chemoresistance in Serous Epithelial Ovarian Carcinoma
- (2010) Ying Dong et al. CANCER RESEARCH
- Breast Cancer Cells in Three-dimensional Culture Display an Enhanced Radioresponse after Coordinate Targeting of Integrin 5 1 and Fibronectin
- (2010) J.-M. Nam et al. CANCER RESEARCH
- Dual Functional Monoclonal Antibody PF-04605412 Targets Integrin 5 1 and Elicits Potent Antibody-Dependent Cellular Cytotoxicity
- (2010) G. Li et al. CANCER RESEARCH
- Increased potency of the PHSCN dendrimer as an inhibitor of human prostate cancer cell invasion, extravasation, and lung colony formation
- (2010) Hongren Yao et al. CLINICAL & EXPERIMENTAL METASTASIS
- Endothelial 5 and v integrins cooperate in remodeling of the vasculature during development
- (2010) A. van der Flier et al. DEVELOPMENT
- Ubiquitination of α5β1 Integrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-Integrin Complexes
- (2010) Viola Hélène Lobert et al. DEVELOPMENTAL CELL
- α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells
- (2010) Eva Martinkova et al. INTERNATIONAL JOURNAL OF CANCER
- ADAM15 to α5β1 integrin switch in colon carcinoma cells: A late event in cancer progression associated with tumor dedifferentiation and poor prognosis
- (2010) Claire Toquet et al. INTERNATIONAL JOURNAL OF CANCER
- Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer
- (2010) Anne-Marie C Dingemans et al. Molecular Cancer
- Integrins as therapeutic targets: lessons and opportunities
- (2010) Dermot Cox et al. NATURE REVIEWS DRUG DISCOVERY
- The final steps of integrin activation: the end game
- (2010) Sanford J. Shattil et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis
- (2010) A K Mitra et al. ONCOGENE
- Integrins and Extracellular Matrix in Mechanotransduction
- (2010) M. A. Schwartz Cold Spring Harbor Perspectives in Biology
- Integrin signaling and lung cancer
- (2010) Francesca Caccavari et al. Cell Adhesion & Migration
- α5β1 Integrin Blockade Inhibits Lymphangiogenesis in Airway Inflammation
- (2009) Tatsuma Okazaki et al. AMERICAN JOURNAL OF PATHOLOGY
- Preclinical Evaluation of the Novel Small-Molecule Integrin α5β1 Inhibitor JSM6427 in Monkey and Rabbit Models of Choroidal Neovascularization
- (2009) Grit Zahn ARCHIVES OF OPHTHALMOLOGY
- Discovery of orally available integrin α5β1 antagonists
- (2009) Gunther Zischinsky et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- SAR of N-phenyl piperidine based oral integrin α5β1 antagonists
- (2009) Gunther Zischinsky et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Integrins
- (2009) Malgorzata Barczyk et al. CELL AND TISSUE RESEARCH
- The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling
- (2009) Tong-Lay Lau et al. EMBO JOURNAL
- Clustering of 5 1 integrins determines adhesion strength whereas v 3 and talin enable mechanotransduction
- (2009) P. Roca-Cusachs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanically Activated Integrin Switch Controls 5 1 Function
- (2009) J. C. Friedland et al. SCIENCE
- Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells
- (2009) Donatella Valdembri et al. PLOS BIOLOGY
- Caveolin-1 regulates glioblastoma aggressiveness through the control of α5β1 integrin expression and modulates glioblastoma responsiveness to SJ749, an α5β1 integrin antagonist
- (2008) Sophie Martin et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Loss of E-Cadherin Promotes Ovarian Cancer Metastasis via 5-Integrin, which Is a Therapeutic Target
- (2008) K. Sawada et al. CANCER RESEARCH
- Rational Design of Highly Active and Selective Ligands for the α5β1 Integrin Receptor
- (2008) Dominik Heckmann et al. CHEMBIOCHEM
- Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds 5 1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study
- (2008) A. D. Ricart et al. CLINICAL CANCER RESEARCH
- Cell-autonomous requirement for 1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice
- (2008) T. R. Carlson et al. DEVELOPMENT
- Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments
- (2008) Patrick T. Caswell et al. JOURNAL OF CELL BIOLOGY
- Caveolin-1-dependent 1 integrin endocytosis is a critical regulator of fibronectin turnover
- (2008) F. Shi et al. JOURNAL OF CELL SCIENCE
- Stimulation of lung carcinoma cell growth by fibronectin–integrin signalling
- (2008) Jeffrey D. Ritzenthaler et al. Molecular BioSystems
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