Review
Biochemistry & Molecular Biology
Xiaohui Ji, Wenqian Zhang, Liqin Yin, Zunhan Shi, Jinwen Luan, Linshan Chen, Longhua Liu
Summary: The number of patients with type 2 diabetes is increasing, posing challenges to public health and economic development. Peroxisome proliferator-activated receptor gamma (PPAR gamma) has been identified as a potential drug target for the treatment of type 2 diabetes. Post-translational modifications (PTMs) of PPAR gamma offer a promising approach to develop safer compounds for diabetes treatment.
Article
Medicine, Research & Experimental
Ya-jun Hou, Dawei Li, Weiqi Wang, Leilei Mao, Xiaoyan Fu, Baoliang Sun, Cundong Fan
Summary: This study evaluated the anticancer effects and mechanism of NT157 against human glioma growth, and found that NT157 alone inhibited glioma cell growth by regulating cell cycle, promoting apoptosis, and inducing DNA damage and dysfunction of signaling pathways. Combined treatment with TRAIL further enhanced apoptosis by upregulating DR5 and inducing DNA damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Peng-Long Li, Mei Li, Zhenya Wang, Xiao-Ming Wang, Shuai-Yang Liu, Song Tian, Zhou-Xiang Wang, Xu Cheng, Yufeng Hu, Peng Zhang, Zhi-Gang She, Hailong Yang, Hongliang Li, Xiao-Jing Zhang
Summary: This study aims to identify promising drug candidates by targeting PPAR gamma for adipogenesis-based metabolic homeostasis and clarify the detailed mechanisms. Magnolol was identified as a potent adipogenesis activator by stabilizing PPAR gamma, providing a new avenue for the therapy of adipogenesis-related metabolic disorder.
Article
Biochemistry & Molecular Biology
Roberta Rapuano, Pamela Ziccardi, Valentina Cioffi, Sabrina Dallavalle, Salvatore Moricca, Angelo Lupo
Summary: The study found that Cladosporols inhibited lipid storage in 3T3-L1 mature adipocytes without affecting the proliferative ability of preadipocytes, and downregulated the expression of differentiation markers in adipogenesis. Additionally, conditioned medium from Cladosporol-treated 3T3-L1 cells inhibited proliferation and migration of HT-29 colorectal cancer cells.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Cell Biology
Simona Cataldi, Marianna Aprile, Caterina Perfetto, Brice Angot, Mireille Cormont, Alfredo Ciccodicola, Jean-Francois Tanti, Valerio Costa
Summary: Adipose tissue dysfunctions are associated with insulin resistance and type 2 diabetes mellitus. Targeting GIP receptor is a valid option for improving the efficacy of GLP-1 receptor agonists in diabetes treatment. However, the therapeutic potential and impact of targeting the GIP/GIPR axis on adipose tissue are controversial.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Syed Nazreen
Summary: The designed and synthesized new thiazolidine-2,4-dione hybrids show potential as PPAR-gamma agonists and thymidylate synthase inhibitors with desired pharmacokinetics properties. Compounds 12 and 11 are the most active, exhibiting significant antitumor activity and thymidylate synthase inhibitory activity.
ARCHIV DER PHARMAZIE
(2021)
Article
Multidisciplinary Sciences
Joanna Niziol, Krzysztof Ossolinski, Aneta Plaza-Altamer, Artur Kolodziej, Anna Ossolinska, Tadeusz Ossolinski, Tomasz Ruman
Summary: In this study, metabolomic profiling was used to identify serum metabolites that can differentiate bladder cancer patients from non-cancer controls. The results showed that twenty-seven metabolites can distinguish between bladder cancer patients and controls, and twenty-three metabolites can differentiate between different grades and stages of bladder cancer. This suggests that measuring serum metabolites could provide a less invasive diagnostic method for bladder cancer detection and management of recurrent disease.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jorge Antonio Silva-Gomez, Marina Galicia-Moreno, Ana Sandoval-Rodriguez, Hipolito Otoniel Miranda-Roblero, Silvia Lucano-Landeros, Arturo Santos, Hugo Christian Monroy-Ramirez, Juan Armendariz-Borunda
Summary: The study evaluated the effects of PFD on early stages of liver cancer development, showing that PFD can prevent tissue damage, reduce fibrosis and inflammation, and promote apoptosis in the experimental model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yong Hao, Shuwei Bai, Jing Peng, Ronghua Hong, Jie Ding, Zezhi Li, Yangtai Guan
Summary: The study suggests that TRIM27 mediates ubiquitination of PPAR gamma, leading to increased expression of cleaved Caspase-3 and IL-1 beta, promoting Glu-induced apoptosis and IL-1 beta release in HT22 cells.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang, Cui Yang, Guan-hua Du
Summary: Avasimibe demonstrated potent anticancer effects on human glioblastoma cells by inhibiting proliferation, inducing apoptosis, and regulating multiple signaling pathways. The drug showed promising potential as a chemotherapy treatment for glioblastoma.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Multidisciplinary Sciences
Francisco J. Sanchez-Rivera, Jeremy Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jacks
Summary: The level of mitochondrial apoptotic priming is a critical determinant of cell fate upon p53 reactivation, with cells having high initial priming tending to undergo apoptosis and cells with low priming tending to survive and arrest in the cell cycle. Manipulating the priming levels through BCL-2 or BCL-XL expression or inhibition can affect the outcome of p53 restoration, highlighting mitochondrial apoptotic priming as a key factor in determining cell fate. Moreover, less primed cells can be forced into apoptotic cell fate following p53 activation using p53-independent drugs that increase apoptotic priming.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Ammad Ahmad Farooqi, Rakhmetova Venera, Gulnara Kapanova, Gulnur Tanbayeva, Gulshara Akhmetova, Yerlan Kudabayev, Assiya Turgambayeva
Summary: Bladder cancer is a challenging disease, and researchers have made significant progress in understanding the mechanisms underlying its development and progression. Restoring apoptosis in drug-resistant cancers, particularly through TRAIL-mediated signaling, shows promise as a valuable treatment strategy. Various natural products and agonistic antibodies have been tested in clinical trials, demonstrating encouraging results in sensitizing drug-resistant bladder cancer cells to apoptosis. Multipronged approaches combining natural products, chemotherapeutics, and agonistic antibodies show potential in well-designed clinical trials.
Article
Medicine, General & Internal
Kai Yang, Jie Shen, Fu-Qing Tan, Xiang-Yi Zheng, Li-Ping Xie
Summary: Activation of the PAWR gene by small double-stranded RNAs (saRNAs) inhibits the growth of bladder cancer cells by inducing apoptosis and cell cycle arrest, through the inactivation of the NF-kappa B and Akt pathways. Additionally, saRNAs cooperate with cisplatin to inhibit bladder cancer cells, suggesting a therapeutic benefit for bladder cancer.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hammad Alam, Vartika Srivastava, Windy Sekgele, Mohmmad Younus Wani, Abdullah Saad Al-Bogami, Julitha Molepo, Aijaz Ahmad
Summary: Candida auris is a pathogenic fungus that is highly resistant to current antifungal drugs. In this study, a derivative called C5 was found to have strong antifungal activity against C. auris and induced apoptosis in the fungal cells. The compound showed high activity with low cytotoxicity. Further in vivo experiments are needed to confirm its effectiveness in animal models.
Review
Chemistry, Organic
Ajay Kumar, Salahuddin, Rajnish Kumar, Rakesh Sahu, Shivali Mishra, Chanchal Singh, Devleena Tiglani
Summary: This article discusses the synthesis of thiazolidinediones and their potential therapeutic effects on diabetes.
MINI-REVIEWS IN ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Analytical
Emmanuelle Albalat, Philippe Telouk, Vincent Balter, Toshiyuki Fujii, Victor Packy Bondanese, Marie-Laure Plissonnier, Virginie Vlaeminck-Guillem, Justine Baccheta, Ndieme Thiam, Pierre Miossec, Fabien Zoulim, Alain Puisieux, Francis Albarede
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2016)
Article
Biotechnology & Applied Microbiology
Jessica Cottarel, Marie-Laure Plissonnier, Majlinda Kullolli, Sharon Pitteri, Sophie Clement, Valentina Millarte, Si-Nafa Si-Ahmed, Hesso Farhan, Fabien Zoulim, Romain Parent
JOURNAL OF GENERAL VIROLOGY
(2016)
News Item
Medicine, Research & Experimental
Marie-Laure Plissonnier, Thomas Lahlali, Patrick Mehlen, Romain Parent
M S-MEDECINE SCIENCES
(2016)
Meeting Abstract
Gastroenterology & Hepatology
R. Barnault, M-L Plissonnier, T. Lahlali, M. Michelet, N. Laverdure, B. Ducarouge, F. Zoulim, P. Mehlen, R. Parent
JOURNAL OF HEPATOLOGY
(2017)
Article
Biochemistry & Molecular Biology
M-L Plissonnier, T. Lahlali, M. Raab, M. Michelet, C. Romero-Lopez, M. Rivoire, K. Strebhardt, D. Durantel, M. Levrero, P. Mehlen, F. Zoulim, R. Parent
Article
Oncology
Marie-Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Christiane Mougin, Jean Rommelaere, Isabelle Lascombe
Article
Biochemistry & Molecular Biology
Romain Barnault, Thomas Lahlali, Marie-Laure Plissonnier, Cristina Romero-Lopez, Noemie Laverdure, Benjamin Ducarouge, Michel Rivoire, Patrick Mehlen, Fabien Zoulim, Romain Parent
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Review
Virology
Marie-Laure Plissonnier, Katharina Herzog, Massimo Levrero, Mirjam B. Zeisel
Article
Virology
Marie-Laure Plissonnier, Jessica Cottarel, Eric Piver, Majlinda Kulioni, Federica Grazia Centonze, Sharon Pitteri, Hesso Farhan, Jean-Christophe Meunier, Fabien Zoulim, Romain Parent
Article
Gastroenterology & Hepatology
Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri
Article
Microbiology
Federica Antonelli, Marco Bartolini, Marie-Laure Plissonnier, Alfonso Esposito, Giulia Galotta, Sandra Ricci, Barbara Davidde Petriaggi, Cristian Pedone, Antonella Di Giovanni, Silvano Piazza, Francesca Guerrieri, Manuela Romagnoli
Article
Gastroenterology & Hepatology
Christophe Gallard, Nadjet Lebsir, Hira Khursheed, Emma Reungoat, Marie-Laure Plissonnier, Jennifer Bre, Maud Michelet, Yasmina Chouik, Fabien Zoulim, Eve-Isabelle Pecheur, Birke Bartosch, Boyan Grigorov
Summary: This study investigates the impact of chronic hepatitis C virus (HCV) infection on the liver extracellular matrix (ECM) and reveals that heparanase-1 (HPSE) plays a promoting role in HCV infection, enhancing the release of the virus by increasing CD63 synthesis and exosome secretion. The study also suggests that virus-induced oxidative stress may regulate HPSE expression through NF-kappa B activation.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Romain Barnault, Claire Verzeroli, Carole Fournier, Maud Michelet, Anna Rita Redavid, Ievgeniia Chicherova, Marie-Laure Plissonnier, Annie Adrait, Olga Khomich, Fleur Chapus, Mathieu Richaud, Maeva Hervieu, Veronika Reiterer, Federica Grazia Centonze, Julie Lucifora, Birke Bartosch, Michel Rivoire, Hesso Farhan, Yohann Coute, Valbona Mirakaj, Thomas Decaens, Patrick Mehlen, Benjamin Gibert, Fabien Zoulim, Romain Parent
Summary: This study identifies Netrin-1 as an inflammation-inducible factor in the liver and reveals its contribution to hepatic inflammation through an atypical mechanism. Additionally, the study finds that an anti-Netrin-1 antibody has anti-inflammatory activity in hepatic inflammation.
Meeting Abstract
Gastroenterology & Hepatology
Oceane Floriot, Giuseppe Rubens Pascucci, Matteo Pallocca, Francesca de Nicola, Michel Rivoire, Marie-Laure Plissonnier, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri
JOURNAL OF HEPATOLOGY
(2019)
Article
Gastroenterology & Hepatology
Thomas Lahlali, Marie-Laure Plissonnier, Cristina Romero-Lopez, Maud Michelet, Benjamin Ducarouge, Alfredo Berzal-Herranz, Fabien Zoulim, Patrick Mehlen, Romain Parent
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2016)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)