Article
Chemistry, Medicinal
Waseem El-Huneidi, Khuloud Bajbouj, Jibran Sualeh Muhammad, Arya Vinod, Jasmin Shafarin, Ghalia Khoder, Mohamed A. Saleh, Jalal Taneera, Eman Abu-Gharbieh
Summary: Carnosic acid inhibits proliferation and survival of human gastric cancer cells in a dose-dependent manner by suppressing the phosphorylation/activation of Akt and mTOR, and enhancing cleavage of PARP as well as downregulating survivin expression.
Article
Biochemistry & Molecular Biology
Wei-liang Sun, Ling-yan He, Li Liang, Si-yu Liu, Jie Luo, Mei-ling Lv, Zheng-wen Cai
Summary: This study identifies a novel pathway, Ambra1-Akt-FoxO1-Bim, which regulates apoptosis and chemosensitivity in breast cancer cells by modulating the expression of the key protein Bim.
Article
Chemistry, Multidisciplinary
Mei-sa Wang, Qiu-shuang Han, Zhi-rong Jia, Chuan-sheng Chen, Chen Qiao, Qian-qian Liu, Ya-meng Zhang, Kai-wei Wang, Jie Wang, Kang Xiao, Xuan-sheng Ding
Summary: Studies have shown that fenofibrate promotes apoptosis by regulating the PPAR alpha/AMPK/AKT/FoxO1 pathway, reducing cholesterol levels and enhancing the anti-proliferative effects of gefitinib in NSCLC cells. Combination treatment of gefitinib and fenofibrate significantly inhibits tumor growth in mouse xenograft models compared to single-drug therapy.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Medicine, Research & Experimental
Xirui Fan, Jinyi Zhou, Xintong Yan, Xiaowen Bi, Juanjuan Liang, Shuai Lu, Lan Luo, Da Zhou, Zhimin Yin
Summary: Citrate can suppress the growth of prostate cancer cells by inducing autophagic cell death, without remarkable toxicity to mice.
Article
Toxicology
Karolina Kowalska, Marta Justyna Koziel, Dominika Ewa Habrowska-Gorczynska, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The PI3K/Akt signaling pathway is one of the most deregulated pathways in prostate cancer, and DON can affect apoptosis and autophagy in normal prostate epithelial cells by modulating this pathway. High concentrations of DON induce apoptosis, while low concentrations induce autophagy.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Mengliang Luo, Zexin Su, Haotian Gao, Jianye Tan, Rongdong Liao, Jiancheng Yang, Lijun Lin
Summary: Cirsiliol inhibits the growth of osteosarcoma cells and induces cell apoptosis by reducing AKT phosphorylation and promoting FOXO1 expression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Shutao Tan, Lin Fu, Qianze Dong
Summary: Dysregulation of AATF is closely associated with human cancers, with elevated expression observed in human bladder cancer. AATF upregulation was found to promote malignant behavior by regulating cyclin E and Survivin, suggesting its potential as a therapeutic target in BC.
ONCOTARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jian Xie, Binhai Mo, Yunhua Lin, Guoqing Liu, Qingqing Nong, Bingling Wu, Yuqian Xie, Tao Li, Lang Li
Summary: This study evaluated the therapeutic effects and underlying mechanisms of human urinary kallidinogenase (HUK) in coronary microembolization (CME)-induced myocardial injury. The results showed that HUK could alleviate myocardial inflammation, apoptosis, and infarction area by activating the PI3K/Akt/FoxO1 axis, suggesting that HUK may have a protective role in CME-induced cardiac injury.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Food Science & Technology
Yuening Sun, Wenjing Guo, Yongjian Guo, Zhangxing Lin, Dechao Wang, Qinglong Guo, Yuxin Zhou
Summary: The study demonstrated that wogonin could induce apoptosis of prostate cancer cells by regulating fatty acid metabolism and activating signaling pathways, showing promising anti-tumor effects.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Fei Sun, Jian Lin Zhou, Si Xing Wei, Ze Wen Jiang, Hao Peng
Summary: This study investigated the role of the PI3K/AKT/FOXO1 signaling pathway and its downstream targets in glucocorticoid-induced osteonecrosis of the femoral head. The results showed that Dex induced osteoblast apoptosis via the PI3K/AKT/FOXO1 signaling pathway, and FOXO1 was proposed as a therapeutic target for this disease.
Article
Cell Biology
Han Dai, Wenjing Hu, Lianying Zhang, Feiyu Jiang, Xiongmin Mao, Gangyi Yang, Ling Li
Summary: Research showed that FGF21 was significantly downregulated in prostate cancer tissues and cell lines, and inhibited PCa cell proliferation and promoted apoptosis through facilitated autophagy.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Kimia Mirzakhani, Julia Kallenbach, Seyed Mohammad Mahdi Rasa, Federico Ribaudo, Martin Ungelenk, Marzieh Ehsani, Wenrong Gong, Nikolaus Gassler, Mirjam Leeder, Marc-Oliver Grimm, Francesco Neri, Aria Baniahmad
Summary: The study identified that supraphysiological androgen levels induce cellular senescence in prostate cancer cells through the activation of p15(INK4b) and AKT phosphorylation, with lncRNASAT1 playing a crucial regulatory role. This novel AR-lncRNASAT1-AKT-p15(INK4b) signaling axis mediates supraphysiological androgen-induced cellular senescence.
Article
Cell Biology
Pan Cai, Yan Lu, Zhifeng Yin, Xiuhui Wang, Xiaoxiao Zhou, Zhuokai Li
Summary: The study used bioinformatics and an in vitro cellular model to investigate the mechanisms underlying the beneficial effects of baicalein (BN) against glucocorticoid-induced osteoporosis. Analysis revealed BN-targeted genes enriched in KEGG pathways, with common pathways related to osteoporosis. Baicalein was found to suppress osteoporosis through an AKT/FOXO1 signaling pathway, partially reversing glucocorticoid-induced osteoporosis in MC3T3-E1 cells.
Article
Biotechnology & Applied Microbiology
Jing Zhang, Xinyan Xu, Yongfeng Chen, Xiaoju Guan, Hong Zhu, Yuhong Qi
Summary: In this study, the regulatory effect of the CRM1-Survivin axis on the progression of ovarian cancer was explored. The results showed that CRM1 silencing inhibited the proliferation and colony formation of ovarian cancer cells and promoted cell apoptosis by promoting Caspase-3 activation. Survivin was positively regulated by CRM1 and promoted the development of ovarian cancer. This suggests that the CRM1-Survivin axis may serve as a potential therapeutic target for ovarian cancer.
Article
Biochemistry & Molecular Biology
Zhiqi Lei, Ilyas Ali, Min Yang, Caixia Yang, Yifei Li, Lian Li
Summary: This study investigated the deleterious effects of NEFA on bovine granulosa cells and its underlying molecular mechanism using an in vitro model. The results showed that high levels of NEFA led to the accumulation of reactive oxygen species, increased apoptosis-related factors, and disrupted steroid hormone synthesis in BGCs. In addition, NEFA inhibited the PI3K/AKT pathway and increased FoxO1 expression. These findings help to clarify the molecular mechanisms underlying the negative effects of NEFA on BGCs.