Role of Non-Neuronal Cells in Body Weight and Appetite Control

A novel role for central ACBP/DBI as a regulator of long-chain fatty acid metabolism in astrocytes

(2015) Khalil Bouyakdan et al.   JOURNAL OF NEUROCHEMISTRY

Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice

(2015) Laura B. Buckman et al.   Molecular Metabolism

Neonatal overfeeding alters hypothalamic microglial profiles and central responses to immune challenge long-term

(2014) Ilvana Ziko et al.   BRAIN BEHAVIOR AND IMMUNITY

Obesity and neuroinflammation: A pathway to cognitive impairment

(2014) Alyson A. Miller et al.   BRAIN BEHAVIOR AND IMMUNITY

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

Hypothalamic Subependymal Niche: A Novel Site of the Adult Neurogenesis

(2014) Ewa Rojczyk-Gołębiewska et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Opposing Effects of Ghrelin on Hypothalamic and Systemic Inflammatory Processes Are Modulated by Its Acylation Status and Food Intake in Male Rats

(2014) Cristina García-Cáceres et al.   ENDOCRINOLOGY

On the value of seasonal mammals for identifying mechanisms underlying the control of food intake and body weight

(2014) Francis J.P. Ebling   HORMONES AND BEHAVIOR

TLR2 Expression in Astrocytes Is Induced by TNF- - and NF- B-Dependent Pathways

(2014) N. K. Phulwani et al.   JOURNAL OF IMMUNOLOGY

Tanycytes: A Gateway to the Metabolic Hypothalamus

(2014) F. Langlet   JOURNAL OF NEUROENDOCRINOLOGY

Betaine recovers hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose-fed rats

(2014) Jian-Mei Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

(2014) Jae Geun Kim et al.   NATURE NEUROSCIENCE

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Dynamic Localization of Glucokinase and Its Regulatory Protein in Hypothalamic Tanycytes

(2014) Magdiel Salgado et al.   PLoS One

Human Astrocytes: Secretome Profiles of Cytokines and Chemokines

(2014) Sung S. Choi et al.   PLoS One

Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

(2014) Yue Wang et al.   PLoS One

Microglial diversity by responses and responders

(2014) Ulla Gertig et al.   Frontiers in Cellular Neuroscience

Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα

(2014) Eugenia Morselli et al.   Cell Reports

Fatty Acids in Energy Metabolism of the Central Nervous System

(2014) Alexander Panov et al.   Biomed Research International

Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice

(2014) Daniel A. Lee et al.   Frontiers in Neuroscience

Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting

(2013) Fanny Langlet et al.   Cell Metabolism

Regulation of Hypothalamic Neuronal Sensing and Food Intake by Ketone Bodies and Fatty Acids

(2013) C. Le Foll et al.   DIABETES

Hypothalamic Inflammation Without Astrogliosis in Response to High Sucrose Intake Is Modulated by Neonatal Nutrition in Male Rats

(2013) Esther Fuente-Martín et al.   ENDOCRINOLOGY

Hormones and diet, but not body weight, control hypothalamic microglial activity

(2013) Yuanqing Gao et al.   GLIA

Oligodendrocyte-microglia cross-talk in the central nervous system

(2013) Laura Peferoen et al.   IMMUNOLOGY

Glucose Regulates Hypothalamic Long-chain Fatty Acid Metabolism via AMP-activated Kinase (AMPK) in Neurons and Astrocytes

(2013) Bouchra Taïb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

(2013) Fanny Langlet et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Differential effects of GH and GH-releasing peptide-6 on astrocytes

(2013) Eva Baquedano et al.   JOURNAL OF ENDOCRINOLOGY

Fgf10-Expressing Tanycytes Add New Neurons to the Appetite/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamus

(2013) N. Haan et al.   JOURNAL OF NEUROSCIENCE

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

MCT2 Expression and Lactate Influx in Anorexigenic and Orexigenic Neurons of the Arcuate Nucleus

(2013) Christian Cortes-Campos et al.   PLoS One

Cerebral Cell Renewal in Adult Mice Controls the Onset of Obesity

(2013) Alexandra Gouazé et al.   PLoS One

Evidence for NG2-glia Derived, Adult-Born Functional Neurons in the Hypothalamus

(2013) Sarah C. Robins et al.   PLoS One

Exposure to Inflammatory Cytokines IL-1β and TNFα Induces Compromise and Death of Astrocytes; Implications for Chronic Neuroinflammation

(2013) Christa van Kralingen et al.   PLoS One

Role of hypothalamic neurogenesis in feeding regulation

(2013) Lígia Sousa-Ferreira et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hypothalamic tanycytes: potential roles in the control of feeding and energy balance

(2013) Matei Bolborea et al.   TRENDS IN NEUROSCIENCES

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors

(2013) S.C. Robins et al.   Nature Communications

Metabolic Aspects of Neuron-Oligodendrocyte-Astrocyte Interactions

(2013) Ana I. Amaral et al.   Frontiers in Endocrinology

Sex differences in adipose tissue

(2013) Esther Fuente-Martín et al.   Adipocyte

Gender-dependent effects of high-fat lard diet on cardiac function in C57Bl/6J mice

(2012) Mieke C. Louwe et al.   Applied Physiology Nutrition and Metabolism

Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity

(2012) Tina Sartorius et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Development of ramified microglia from early macrophages in the zebrafish optic tectum

(2012) Adam J. Svahn et al.   Developmental Neurobiology

Developmental Origins of Astrocyte Heterogeneity: The Final Frontier of CNS Development

(2012) Lesley S. Chaboub et al.   DEVELOPMENTAL NEUROSCIENCE

Gliotransmission and Brain Glucose Sensing: Critical Role of Endozepines

(2012) D. Lanfray et al.   DIABETES

Protective role of neuropeptide Y Y2receptors in cell death and microglial response following methamphetamine injury

(2012) Joana Gonçalves et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Apolipoprotein E protects astrocytes from hypoxia and glutamate-induced apoptosis

(2012) Shuai Zhou et al.   FEBS LETTERS

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

Sex, glia, and development: Interactions in health and disease

(2012) Jaclyn M. Schwarz et al.   HORMONES AND BEHAVIOR

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes

(2012) Esther Fuente-Martín et al.   JOURNAL OF CLINICAL INVESTIGATION

Food Intake Adaptation to Dietary Fat Involves PSA-Dependent Rewiring of the Arcuate Melanocortin System in Mice

(2012) A. Benani et al.   JOURNAL OF NEUROSCIENCE

Infant satiety depends on transient expression of cholecystokinin-1 receptors on ependymal cells lining the third ventricle in mice

(2012) Tomoya Ozaki et al.   JOURNAL OF PHYSIOLOGY-LONDON

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

(2012) Juxue Li et al.   NATURE CELL BIOLOGY

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

(2012) Daniel A Lee et al.   NATURE NEUROSCIENCE

Effect of leptin administration on myelination in ob/ob mouse cerebrum after birth

(2012) Ryuju Hashimoto et al.   NEUROREPORT

Exercise protects against high-fat diet-induced hypothalamic inflammation

(2012) Chun-Xia Yi et al.   PHYSIOLOGY & BEHAVIOR

A putative functional role for oligodendrocytes in mood regulation

(2012) N Edgar et al.   Translational Psychiatry

Emerging role of glial cells in the control of body weight

(2012) Cristina García-Cáceres et al.   Molecular Metabolism

High calorie diet triggers hypothalamic angiopathy

(2012) Chun-Xia Yi et al.   Molecular Metabolism

Morphofunctional Aspects of the Blood-Brain Barrier

(2011) Beatrice Nico et al.   CURRENT DRUG METABOLISM

Metabolic Sensing and the Brain: Who, What, Where, and How?

(2011) Barry E. Levin et al.   ENDOCRINOLOGY

Differential Acute and Chronic Effects of Leptin on Hypothalamic Astrocyte Morphology and Synaptic Protein Levels

(2011) Cristina García-Cáceres et al.   ENDOCRINOLOGY

The evolutionary origins of glia

(2011) Daniel K. Hartline   GLIA

Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice

(2011) David E.G. McNay et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Sex differences in microglial colonization of the developing rat brain

(2011) Jaclyn M. Schwarz et al.   JOURNAL OF NEUROCHEMISTRY

Activation of Microglia in Specific Hypothalamic Nuclei and the Cerebellum of Adult Rats Exposed to Neonatal Overnutrition

(2011) S. Tapia-González et al.   JOURNAL OF NEUROENDOCRINOLOGY

Postnatal Overfeeding Leads to Obesity and Exacerbated Febrile Responses to Lipopolysaccharide Throughout Life

(2011) M. A. Clarke et al.   JOURNAL OF NEUROENDOCRINOLOGY

Glial Regulation of Neuronal Function: From Synapse to Systems Physiology

(2011) J. G. Tasker et al.   JOURNAL OF NEUROENDOCRINOLOGY

Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells

(2011) Raquel Ferreira et al.   Journal of Neuroinflammation

Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation

(2011) Yi-Fang Tu et al.   Journal of Neuroinflammation

ATP-mediated glucosensing by hypothalamic tanycytes

(2011) Cameron Frayling et al.   JOURNAL OF PHYSIOLOGY-LONDON

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

MCT Expression and Lactate Influx/Efflux in Tanycytes Involved in Glia-Neuron Metabolic Interaction

(2011) Christian Cortés-Campos et al.   PLoS One

Purinergic signaling in hypothalamic tanycytes: Potential roles in chemosensing

(2011) Nicholas Dale   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Detection of extracellular glucose by GLUT2 contributes to hypothalamic control of food intake

(2010) Emilie Stolarczyk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: The role of tumor necrosis factor-α

(2010) Yi Zhong et al.   BRAIN BEHAVIOR AND IMMUNITY

Direct and indirect effects of neuropeptide Y and neurotrophin 3 on myelination in the neonatal brains

(2010) Ryuju Hashimoto et al.   BRAIN RESEARCH

Inhibition of Apoptotic Cell Death by Ghrelin Improves Functional Recovery after Spinal Cord Injury

(2010) Jee Y. Lee et al.   ENDOCRINOLOGY

Changes in Melanocortin Expression and Inflammatory Pathways in Fetal Offspring of Nonhuman Primates Fed a High-Fat Diet

(2010) B. E. Grayson et al.   ENDOCRINOLOGY

IGF-I stimulates neurogenesis in the hypothalamus of adult rats

(2010) M. Pérez-Martín et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Enduring consequences of maternal obesity for brain inflammation and behavior of offspring

(2010) Staci D. Bilbo et al.   FASEB JOURNAL

Astrocytes Modulate Distribution and Neuronal Signaling of Leptin in the Hypothalamus of Obese A vy Mice

(2010) Weihong Pan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Role of astrocytic leptin receptor subtypes on leptin permeation across hCMEC/D3 human brain endothelial cells

(2010) Hung Hsuchou et al.   JOURNAL OF NEUROCHEMISTRY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

(2010) T. L. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Developmental changes in hypothalamic leptin receptor: relationship with the postnatal leptin surge and energy balance neuropeptides in the postnatal rat

(2009) E. C. Cottrell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Obesity induces functional astrocytic leptin receptors in hypothalamus

(2009) H. Hsuchou et al.   BRAIN

Leptin modulates cell morphology and cytokine release in microglia

(2009) Véronique Lafrance et al.   BRAIN BEHAVIOR AND IMMUNITY

Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation

(2009) Tu-Hsueh Yeh et al.   GLIA

Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain

(2009) Amandine Mullier et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Relationship among Brain and Blood Glucose Levels and Spontaneous and Glucoprivic Feeding

(2009) A. A. Dunn-Meynell et al.   JOURNAL OF NEUROSCIENCE

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

(2009) Michael M. Halassa et al.   NEURON

Astrocyte-Mediated Distributed Plasticity at Hypothalamic Glutamate Synapses

(2009) Grant R.J. Gordon et al.   NEURON

Leptin receptor mRNA in rat brain astrocytes

(2009) Hung Hsuchou et al.   PEPTIDES

Neonatal bacterial infection alters fever to live and simulated infections in adulthood

(2009) Staci D. Bilbo et al.   PSYCHONEUROENDOCRINOLOGY

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Early-life programming of later-life brain and behavior: a critical role for the immune system

(2009) Staci D. Bilbo   Frontiers in Behavioral Neuroscience

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo

(2008) Francesca Peri et al.   CELL

Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain

(2008) Zaman Mirzadeh et al.   Cell Stem Cell

Brain Apolipoprotein E: an Important Regulator of Food Intake in Rats

(2008) L. Shen et al.   DIABETES

Astrocyte Leptin Receptor (ObR) and Leptin Transport in Adult-Onset Obese Mice

(2008) Weihong Pan et al.   ENDOCRINOLOGY

Reduced synaptic activity precedes synaptic stripping in vagal motoneurons after axotomy

(2008) Jun Yamada et al.   GLIA

Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex

(2008) L. Dimou et al.   JOURNAL OF NEUROSCIENCE

Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellumin vivo

(2008) Kirsten Caesar et al.   JOURNAL OF PHYSIOLOGY-LONDON

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

(2008) Leanne E Rivers et al.   NATURE NEUROSCIENCE

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL

NG2 cells generate oligodendrocytes and gray matter astrocytes in the spinal cord

(2008) Xiaoqin Zhu et al.   Neuron Glia Biology

Activity-Dependent Structural and Functional Plasticity of Astrocyte-Neuron Interactions

(2008) Dionysia T. Theodosis et al.   PHYSIOLOGICAL REVIEWS

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE