Article
Biochemistry & Molecular Biology
Young Rae Jo, Hye Ran Kim, So Young Jang, Hana Go, Min-Young Song, Da Kyeong Park, Yuna Oh, Juyeon Jo, Yoon Kyung Shin, Sung Joong Lee, Sang-Myung Cheon, Hyun Kyoung Lee, Kyung Eun Lee, Young Hye Kim, Hwan Tae Park
Summary: The study found that a large population of central neurons are derived from Cnp-expressing neuroglial stem cells; conditional gene targeting using the Cnp promoter, known to be OL-specific, can induce neuron-autonomous phenotypes.
Article
Biochemistry & Molecular Biology
Yu-Chieh Chen, Jiunn-Ming Sheen, Su-Chen Wang, Mei-Hsin Hsu, Chih-Cheng Hsiao, Kow-Aung Chang, Li-Tung Huang
Summary: Research has shown that MTX treatment affects spatial memory function in developing rats, and this effect can be rescued by melatonin. MTX treatment also alters epigenetic modifications on myelination process, particularly in the hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Andrea D. Rivera, Francesca Pieropan, Irene Chacon-De-La-Rocha, Davide Lecca, Maria P. Abbracchio, Kasum Azim, Arthur M. Butt
Summary: Brain ageing is characterized by a decline in neuronal function and cognitive deficits, with myelin disruption being identified as a significant factor contributing to the loss of brain plasticity and repair responses. Through a combined systems biology and neurobiological approach, it was found that oligodendroglial and myelin genes are highly altered in the aging mouse cerebrum, with the G-protein coupled receptor Gpr17 being central to the disruption of OPCs in aging. Systems biology strategies were used to identify therapeutic agents that rejuvenate OPCs and restore myelination in age-related neuropathological contexts.
Article
Biochemistry & Molecular Biology
Lingyu Shi, Zongyi Wang, Yujiao Li, Zheng Song, Wu Yin, Bing Hu
Summary: This study reveals the critical role of chd7 in oligodendrocyte migration and myelination in zebrafish, potentially associated with CHARGE syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Assia Tiane, Melissa Schepers, Renzo Riemens, Ben Rombaut, Patrick Vandormael, Veerle Somers, Jos Prickaerts, Niels Hellings, Daniel van den Hove, Tim Vanmierlo
Summary: In this study, researchers identified Id2 and Id4 as targets of DNA methylation during the differentiation of oligodendrocyte precursor cells. Using CRISPR technology, they confirmed that methylation of Id2/Id4 could drive cell differentiation. Furthermore, they found alterations in methylation and gene expression levels of these genes in multiple sclerosis patients compared to controls.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Cell Biology
Tomohiro Torii, Tomohiro Miyasaka, Hiroaki Misonou
Summary: This review article discusses the presence of tau in oligodendrocytes and its potential impact on oligodendrocyte function. The study shows that the expression levels of tau significantly change in hypomyelination models and in demyelination regions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Irena Smaga
Summary: This review summarizes the current knowledge on the role of myelin-related changes in depression, as well as the relationship among maternal malnutrition, myelination, and depression. The findings suggest that myelin alterations play a significant role in the development of depression.
Article
Biochemistry & Molecular Biology
Ruyi Mei, Wanwan Qiu, Yingying Yang, Siyu Xu, Yueyu Rao, Qingxin Li, Yuhao Luo, Hao Huang, Aifen Yang, Huaping Tao, Mengsheng Qiu, Xiaofeng Zhao
Summary: This study reveals that Ddr1 is selectively upregulated in newly differentiated oligodendrocytes in the early postnatal CNS and plays a crucial role in oligodendrocyte differentiation and myelination. Ddr1 deficiency leads to compromised axonal myelination and motor dysfunction, activating the ERK pathway in the CNS. Additionally, Ddr1 is important for myelin repair after lysolecithin-induced demyelination. Overall, this study sheds light on the role of Ddr1 in myelin development and repair in the CNS and provides a novel target for treating demyelinating diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Shuang-Ling Wu, Bin Yu, Yong-Jie Cheng, Shu-Yu Ren, Fei Wang, Lan Xiao, Jing-Fei Chen, Feng Mei
Summary: Alzheimer's disease (AD) is characterized by the presence of aggregated amyloid beta-protein (Aβ). Recent evidence suggests that inadequate myelinogenesis plays a role in AD-related functional deficits. The relationship between Aβ and myelinogenesis in AD brains, however, remains unclear.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Cell Biology
Kristen H. Schuster, Alexandra F. Putka, Hayley S. McLoughlin
Summary: Emerging evidence suggests that non-neuronal cells, especially oligodendrocytes, play a role in the pathophysiology of various neurodegenerative diseases. This study utilized primary oligodendrocyte cultures to investigate the effects of known pathogenic mechanisms of SCA3 on this cell type. The findings demonstrate the utility of primary oligodendrocyte culture in studying cell-specific pathway dysregulation relevant to SCA3.
Review
Neurosciences
Minkyung Kang, Yao Yao
Summary: Oligodendrocytes are crucial cells in the central nervous system responsible for myelinating axons and supporting the function of neurons. The function and development of oligodendrocytes are tightly regulated by various molecules, with laminin playing a significant role in processes such as survival, migration, proliferation, differentiation, and myelination. Understanding the specific molecular targets and signaling pathways in oligodendrocyte biology may have implications for therapeutic interventions in demyelinating diseases.
Article
Neurosciences
He Wang, Mengjia Liu, Zhuoyang Ye, Cuihua Zhou, Huiru Bi, Long Wang, Chen Zhang, Hui Fu, Ying Shen, Jian-Jun Yang, Yimin Hu, Guiquan Chen
Summary: This study reveals that the phosphorylation of FoxO1 by Akt plays a critical role in Sox10 expression and OL differentiation. Deletion of all three Akt isoforms leads to downregulation of Sox10, and mutant FoxO1 inhibits Sox10 promoter activity.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Matthew Swire, Peggy Assinck, Peter A. McNaughton, David A. Lyons, Charles Ffrench-Constant, Matthew R. Livesey
Summary: HCN2 ion channels play a key role in regulating myelin sheath length in the central nervous system. Pharmacological blockade or genetic knockout of HCN2 can affect myelin sheath length, highlighting their importance in the relationship between neuronal activity and myelin formation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Kristin D. Dahl, Adam R. Almeida, Hannah A. Hathaway, Jennifer Bourne, Tanya L. Brown, Lisbet T. Finseth, Teresa L. Wood, Wendy B. Macklin
Summary: In the Central Nervous System (CNS), oligodendrocyte progenitor cells (OPCs) differentiate into mature oligodendrocytes that generate myelin, crucial for normal nervous system function. This study focused on the role of mTORC2 signaling in OPCs using PDGFRa-Cre X Rictorfl/fl mice. Loss of mTORC2 in OPCs led to early reduction in myelin RNAs and proteins, with more severe hypomyelination and increased unmyelinated axons observed in the corpus callosum compared to the spinal cord. The study revealed regionally specific effects of mTORC2 signaling in OPCs, particularly in the corpus callosum.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Yan Chen, Zheng Zheng, Ainong Mei, Huan Huang, Fan Lin
Summary: The study revealed that the expression levels of claudin-1 and claudin-3 were downregulated in leukoaraiosis patients, and their overexpression reduced apoptosis in oligodendrocytes and promoted the expression of myelinogenesis-related proteins.
Article
Pediatrics
Tomoyuki Motoya, Noriko Ogawa, Tetsuya Nitta, Ashiq Mahmood Rafiq, Esrat Jahan, Motohide Furuya, Akihiro Matsumoto, Jun Udagawa, Hiroki Otani
CONGENITAL ANOMALIES
(2016)
Article
Pediatrics
Tomoyuki Motoya, Noriko Ogawa, Tetsuya Nitta, Ashiq Mahmood Rafiq, Esrat Jahan, Motohide Furuya, Akihiro Matsumoto, Jun Udagawa, Hiroki Otani
CONGENITAL ANOMALIES
(2016)
Article
Pediatrics
Ryo Kaneda, Yuko Saeki, Dereje Getachew, Akihiro Matsumoto, Motohide Furuya, Noriko Ogawa, Tomoyuki Motoya, Ashiq M. Rafiq, Esrat Jahan, Jun Udagawa, Ryuju Hashimoto, Hiroki Otani
CONGENITAL ANOMALIES
(2018)
Article
Endocrinology & Metabolism
Tomoko Kimura, Kodai Hino, Tadaaki Kono, Atsushi Takano, Norihisa Nitta, Noritoshi Ushio, Shinjiro Hino, Ryuta Takase, Motoi Kudo, Yataro Daigo, Wataru Morita, Mitsuyoshi Nakao, Masato Nakatsukasa, Toshihiro Tamagawa, Ashiq Mahmood Rafiq, Akihiro Matsumoto, Hiroki Otani, Jun Udagawa
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2018)
Article
Anatomy & Morphology
Ashiq Mahmood Rafiq, Jun Udagawa, Torbjorn Lundh, Esrat Jahan, Akihiro Matsumoto, Joji Sekine, Hiroki Otani
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2012)
Article
Anatomy & Morphology
Makiko Yamada, Jun Udagawa, Ryuju Hashimoto, Akihiro Matsumoto, Toshihisa Hatta, Hiroki Otani
ANATOMICAL SCIENCE INTERNATIONAL
(2013)
Article
Dentistry, Oral Surgery & Medicine
Esrat Jahan, Akihiro Matsumoto, Ashiq Mahmood Rafiq, Ryuju Hashimoto, Takayuki Inoue, Jun Udagawa, Joji Sekine, Hiroki Otani
ARCHIVES OF ORAL BIOLOGY
(2014)
Article
Pediatrics
Mai Kawamoto, Jun Udagawa, Ryuju Hashimoto, Akihiro Matsumoto, Makiko Yamada, Masayuki Nimura, Hiroki Otani
CONGENITAL ANOMALIES
(2011)
Article
Endocrinology & Metabolism
Takayuki Inoue, Ryuju Hashimoto, Akihiro Matsumoto, Esrat Jahan, Ashiq Mahmood Rafiq, Jun Udagawa, Toshihisa Hatta, Hiroki Otani
JOURNAL OF BONE AND MINERAL RESEARCH
(2014)
Article
Neurosciences
Ryuju Hashimoto, Akihiro Matsumoto, Jun Udagawa, Kyoji Hioki, Hiroki Otani
Article
Pediatrics
Dereje Getachew, Ryo Kaneda, Yuko Saeki, Akihiro Matsumoto, Hiroki Otani
Summary: The apico-basal polarity of epithelial cells relies on the organized arrays of the cytoskeleton and adhesion apparatus. In mouse embryonic esophageal epithelium, the rearrangement of the cytoskeleton and adhesion apparatus seems to be closely associated with the conversion from pseudostratified single columnar to stratified squamous morphology, as well as the cessation of interkinetic nuclear migration.
CONGENITAL ANOMALIES
(2021)
Article
Anatomy & Morphology
Esrat Jahan, Ashiq Mahmood Rafiq, Akihiro Matsumoto, Nusrat Jahan, Hiroki Otani
Summary: The study observed the development of the smooth muscle layer (SML) in the mouse ileum near the ileocecal junction, revealing that smooth muscle cells (SMCs) in the inner circular layer (IC) change from oval-shaped and irregularly arranged to elongated spindle shape with a decreased number of layers. In the outer longitudinal layer (OL), a single layer of SMC is observed at a later stage with a different cell orientation compared to IC. The study suggests that the development and differentiation of the ileal SML is complex and possibly related to macroscopic organogenesis.
ANATOMICAL SCIENCE INTERNATIONAL
(2021)
Article
Pediatrics
Dereje Getachew, Akihiro Matsumoto, Yasuhiro Uchimura, Jun Udagawa, Nanako Mita, Noriko Ogawa, Shigeru Moriyama, Akiyasu Takami, Hiroki Otani
Summary: The research found differences in cell nuclear movements between the trachea and esophagus, as well as significant regional differences within the trachea but not the esophagus. These differences may be related to the distinct organogenesis process of the two organs.
CONGENITAL ANOMALIES
(2021)
Article
Biochemistry & Molecular Biology
Shohei Fukunaga, Noriko Ogawa, Akihiro Matsumoto, Takafumi Ito, Kazuaki Tanabe, Hiroki Otani
Summary: The prevalence of chronic kidney disease (CKD) is increasing globally, and its risk is associated with glomerular number. This study found that the administration of retinoic acid (RA) to pregnant mice increased fetal glomerular number, providing a method to investigate whether increasing glomerular number can reduce CKD risk.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.