Journal
CELL METABOLISM
Volume 16, Issue 6, Pages 693-705Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2012.11.001
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Funding
- Swedish Research Council
- Stockholm City Council (ALF)
- Swedish Heart-Lung Foundation
- Swedish Diabetes Foundation
- Swedish Kidney Foundation
- Karolinska Institute
- Swedish Foundation for Strategic Research
- Cardiovascular Program, Karolinska Institute/Stockholm County Council
- Eli Lilly
- Albireo
- AstraZeneca
- KaroBio
- AB Albireo
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The circulating FGFs are a new group of proteins believed to function as classic hormones. With emphasis on human metabolism, we critically review current data, and propose that-although a number of questions remain-circulating FGF23 is pivotal in the control of phosphate and vitamin D metabolism, and may have additional systemic effects, particularly in chronic kidney disease; that FGF19 signaling is important for the regulation of bile acid metabolism, whereas its physiological role in promoting glucose and lipid metabolism is less well understood; and that the physiological role of circulating FGF21 in metabolic homeostasis warrants further investigation.
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