Article
Biochemistry & Molecular Biology
Jimena Leyria, Riya Philip, Ian Orchard, Angela B. Lange
Summary: Insulin-like peptides (ILPs) are crucial hormones found in all organisms, and a newly discovered ILP called gonadulin has been found to be highly expressed in the reproductive system of Rhodnius prolixus insects. In this study, it was observed that impairment of the gonadulin signaling cascade inhibited ovulation and oviposition, leading to egg retention. Understanding the reproductive processes in R. prolixus could provide insights for the development of biopesticides to control insect populations and disease transmission.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Marc Tatar
Summary: Mutations of the insulin-like receptor in Drosophila can extend lifespan through two modes of operation, one slowing reproduction and growth, and the other prolonging lifespan without impairing growth and reproduction. The structure of the insulin receptor can modulate aging by influencing the balance between reproduction and survival in fruit flies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Rochele Yamamoto, Michael Palmer, Helen Koski, Noelle Curtis-Joseph, Marc Tatar
Summary: Mutations in the Drosophila insulin receptor can affect growth, reproduction, and lifespan, with one specific mutation in the kinase insert domain extending lifespan without impacting growth or reproduction. The study suggests that these mutations may influence aging by interfering with the kinase's function.
Article
Biochemistry & Molecular Biology
Jimena Leyria, Ian Orchard, Angela B. Lange
Summary: Insulin signaling in insects, such as the blood-gorging triatomine R. prolixus, plays a crucial role in metabolism, growth, and reproduction, with a direct effect on ovarian follicles and egg production. The up-regulation of insulin/ToR signaling transcripts in unfed insects suggests a heightened sensitivity to respond rapidly to nutrient levels, while the pathway is only activated in fed insects. This study demonstrates a mechanism by which nutritional signaling regulates reproductive performance in insects, offering potential implications for the development of biocontrol methods.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biology
Vannajan Sanghiran Lee, Sri Devi Sukumaran, Tan Pak Kheong, Umah Rani Kuppusamy, Bavani Arumugam
Summary: This study investigates the impact of charge-specific modification on the interaction between insulin and its receptor, using molecular modelling to analyze the effects on protein stability and bioavailability. Results show that guanidination of insulin enhances the binding to its receptor through electrostatic interactions, providing insights for potential mechanisms of action at a molecular level before moving on to real experiments.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Cecilia Mittelberger, Bettina Hause, Katrin Janik
Summary: The study reveals the interaction between the bacterial pathogen 'Candidatus Phytoplasma mali' and MdTCP16 gene, which may contribute to the characteristic symptoms of apple proliferation disease.
Article
Multidisciplinary Sciences
Justin Clements, Benjamin Z. Bradford, Marjorie Garcia, Shannon Piper, Weijie Huang, Agnieszka Zwolinska, Kurt Lamour, Saskia Hogenhout, Russell L. Groves
Summary: Aster Yellows phytoplasma, transmitted by the aster leafhopper, is a bacterial pathogen causing diseases in herbaceous plants. The progression of the disease is significantly associated with calendar date, crop density, field location, and phytoplasma subgroup.
Review
Entomology
Hui Wang, Qian Chen, Taiyun Wei
Summary: This review discusses the impact of insect viruses on the transmission of arboviruses by insects, as well as potential strategies for disease control.
Article
Biochemistry & Molecular Biology
Ting Lu, Yujie Lu, Lei Wang, Zhipei Liu, Shiyuan Miao, Yajie Tai, Binbin Yang
Summary: The Akt gene plays an important role in regulating female reproduction in Liposcelis entomophila by affecting the juvenile hormone signaling pathway and vitellogenesis.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hui Xue, Xingxing Huang, Guofeng Chang, Weihua Ma, J. Joe Hull, Lizhen Chen
Summary: This study investigated the reproductive capacity of Adelphocoris suturalis through RNAi-mediated knockdown, revealing that knockdown of AsIRS1 significantly reduced egg maturation and had effects on lifetime fecundity, egg hatch rate, and other reproductive parameters. These findings suggest that the insulin signaling pathway, particularly IRS1, plays a key role in the reproductive development of A. suturalis.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carl Procko, Wen Mai Wong, Janki Patel, Seyed Ali Reza Mousavi, Tsegaye Dabi, Marc Duque, Lisa Baird, Sreekanth H. Chalasani, Joanne Chory
Summary: The evolution of the Venus flytrap's ability to sense, capture, and digest animal prey has long been a mystery in the scientific community. Recent genome and transcriptome sequencing studies have provided some insight into the genes involved in these tasks, but proving a direct link has been challenging. In this study, researchers used CRISPR-Cas9 methods to modify the Venus flytrap genome and found that mutations in two mechanosensitive ion channel genes led to a reduced response in leaf-closing behavior. The findings suggest that multiple redundant ion channels play a role in the plant's sensory system for prey detection.
Review
Entomology
Aditi Kulkarni, Frida M. Delgadillo, Sharan Gayathrinathan, Brian I. Grajeda, Sourav Roy
Summary: Insect vectors play a crucial role in transmitting diseases, and understanding the molecular interactions that affect their behavior and physiology is important for developing effective strategies to control disease transmission. This review provides a comprehensive overview of the current knowledge in omics-based research on vector species, highlighting potential targets for vector control and discussing advancements and gaps in our understanding. Insights into the post-mating molecular responses in female vectors can contribute to the development of novel vector control methods.
Article
Medicine, Research & Experimental
Gulibositan Aji, Sheng Jiang, Halmurat Obulkasim, Zhiqiang Lu, Wei Wang, Pu Xia
Summary: This study reveals that SphK2 regulates the trafficking of insulin receptor (InsR) by affecting the endocytosis and recycling of InsR, thus modulating insulin signaling. These findings provide mechanistic evidence for SphK2 as a potential intervention target for insulin resistance and type 2 diabetes (T2D).
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Entomology
Ziye Wang, Delong Tan, Feifeng Wang, Shuhao Guo, Jinhua Liu, Andrew G. S. Cuthbertson, Baoli Qiu, Wen Sang
Summary: This study found that the expression levels of upstream factors DcILP1, DcILP2, and DcIR in the insulin signaling system of Diaphorina citri are upregulated after feeding on young shoots, which in turn influences the expression of the upstream regulatory gene DcRheb of the TOR signaling pathway and eventually leads to the maturation of the ovaries and oviposition behavior of female D. citri.
Article
Microbiology
Heng Li, Yixin Chen, Chengcong Lu, Houjun Tian, Shuo Lin, Liang Wang, Tingting Linghu, Xue Zheng, Hui Wei, Xiaojing Fan, Yong Chen
Summary: This study reveals that a plant virus induces the production of a specific volatile in its host plant, which is recognized by an olfactory protein in its insect vector. This manipulation of insect behavior by the virus enhances viral spread and transmission. The findings shed light on how plant viruses control insect vector behavior through chemical signals.
Review
Chemistry, Medicinal
Verena Gelmedin, Colette Dissous, Christoph G. Grevelding
FUTURE MEDICINAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Catherine Leroy, Natalya V. Belkina, Thavy Long, Emeric Deruy, Colette Dissous, Stephen Shaw, David Tulasne
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Infectious Diseases
Thavy Long, R. Jeffrey Neitz, Rachel Beasley, Chakrapani Kalyanaraman, Brian M. Suzuki, Matthew P. Jacobson, Colette Dissous, James H. McKerrow, David H. Drewry, William J. Zuercher, Rahul Singh, Conor R. Caffrey
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Article
Biotechnology & Applied Microbiology
Mathieu Vanderstraete, Nadege Gouignard, Arnaud Ahier, Marion Morel, Jerome Vicogne, Colette Dissous
Letter
Immunology
Meenu Sharma, Maxime Lecerf, Alain Friboulet, Srini V. Kaveri, Colette Dissous, Jagadeesh Bayry
JOURNAL OF INFECTIOUS DISEASES
(2014)
Article
Multidisciplinary Sciences
Thavy Long, Mathieu Vanderstraete, Katia Cailliau, Marion Morel, Arlette Lescuyer, Nadege Gouignard, Christoph G. Grevelding, Edith Browaeys, Colette Dissous
Article
Multidisciplinary Sciences
Svenja Beckmann, Thomas Quack, Colette Dissous, Katia Cailliau, Gabriele Lang, Christoph G. Grevelding
Article
Infectious Diseases
Mathieu Vanderstraete, Nadege Gouignard, Katia Cailliau, Marion Morel, Julien Lancelot, Jean-Francois Bodart, Colette Dissous
PLOS NEGLECTED TROPICAL DISEASES
(2013)
Article
Infectious Diseases
Christin Buro, Svenja Beckmann, Katia C. Oliveira, Colette Dissous, Katia Cailliau, Richard J. Marhoefer, Paul M. Selzer, Sergio Verjovski-Almeida, Christoph G. Grevelding
PLOS NEGLECTED TROPICAL DISEASES
(2014)
Article
Infectious Diseases
Andreas Schubert, Uriel Koziol, Katia Cailliau, Mathieu Vanderstraete, Colette Dissous, Klaus Brehm
PLOS NEGLECTED TROPICAL DISEASES
(2014)
Article
Microbiology
Mathieu Vanderstraete, Nadege Gouignard, Katia Cailliau, Marion Morel, Steffen Hahnel, Silke Leutner, Svenja Beckmann, Christoph G. Grevelding, Colette Dissous
Article
Parasitology
Marion Morel, Mathieu Vanderstraete, Katia Cailliau, Arlette Lescuyer, Julien Lancelot, Colette Dissous
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2014)
Review
Endocrinology & Metabolism
Colette Dissous, Marion Morel, Mathieu Vanderstraete
FRONTIERS IN ENDOCRINOLOGY
(2014)
Review
Pharmacology & Pharmacy
Svenja Beckmann, Silke Leutner, Nadege Gouignard, Colette Dissous, Christoph G. Grevelding
CURRENT PHARMACEUTICAL DESIGN
(2012)