Article
Biology
Jack Rhodes, Andra-Octavia Roman, Marta Bjornson, Benjamin Brandt, Paul Derbyshire, Michele Wyler, Marc W. Schmid, Frank L. H. Menke, Julia Santiago, Cyril Zipfel
Summary: This study reports on a previously uncharacterised family of plant signalling peptides, CTNIPs, and identifies the orphan receptor HSL3 as their receptor. The HSL3-CTNIP signalling module is conserved in most extant angiosperms. This discovery is important for understanding the diverse functions of plant signalling peptides and receptor-ligand co-evolution.
Article
Biochemistry & Molecular Biology
Carl Procko, Wen Mai Wong, Janki Patel, Seyed Ali Reza Mousavi, Tsegaye Dabi, Marc Duque, Lisa Baird, Sreekanth H. Chalasani, Joanne Chory
Summary: The evolution of the Venus flytrap's ability to sense, capture, and digest animal prey has long been a mystery in the scientific community. Recent genome and transcriptome sequencing studies have provided some insight into the genes involved in these tasks, but proving a direct link has been challenging. In this study, researchers used CRISPR-Cas9 methods to modify the Venus flytrap genome and found that mutations in two mechanosensitive ion channel genes led to a reduced response in leaf-closing behavior. The findings suggest that multiple redundant ion channels play a role in the plant's sensory system for prey detection.
Article
Biotechnology & Applied Microbiology
Ning-Na Yin, Shu-Mei Nuo, Hai-Yan Xiao, Yu-Jie Zhao, Jia-Ying Zhu, Nai-Yong Liu
Summary: The study revealed differences in ionotropic receptor (IR) genes in Lepidoptera and Trichoptera, the most diverse insect orders representing terrestrial and aquatic insects. Phylogenetic analysis classified the IRs into three subfamilies, with A-IRs and LS-IRs showing high conservation in gene structure, while D-IRs exhibited low amino acid identities. Expression profiles showcased functional diversities of IRs in specific chemosensory behaviors of male and female adults in Bombyx mori and Papilio xuthus.
Article
Astronomy & Astrophysics
Noam R. Izenberg, Diana M. Gentry, David J. Smith, Martha S. Gilmore, David H. Grinspoon, Mark A. Bullock, Penelope J. Boston, Grzegorz P. Slowik
Summary: Ancient Venus and Earth may have had similar conditions necessary for the development of life, with the possibility that life originated on Venus and has survived through time. The Venus Life Equation introduces a new method for calculating the probability of life on Venus, highlighting areas for future exploration missions to address.
Article
Astronomy & Astrophysics
Jean-Luc Margot, Donald B. Campbell, Jon D. Giorgini, Joseph S. Jao, Lawrence G. Snedeker, Frank D. Ghigo, Amber Bonsall
Summary: By utilizing radar observations, fundamental properties of Venus such as its spin axis tilt, precession rate, moment of inertia, and length-of-day variations have been determined. Venus has a tilt of 2.6392 degrees, precession rate of 44.58 arcsec per year, an average sidereal day of 243.0226 Earth days between 2006 and 2020, with observed variations.
Article
Plant Sciences
Zhiqiang Zhang, Wenqi Huo, Xingxing Wang, Zhongying Ren, Junjie Zhao, Yangai Liu, Kunlun He, Fei Zhang, Wei Li, Shuangxia Jin, Daigang Yang
Summary: This study comprehensively analyzed the origin, evolution, and diversification of the wall-associated kinase (WAK) gene family in plants. The results revealed the origin, evolution, and diversification of WAK genes in green plants. The functional diversity of WAK genes in Arabidopsis and rice was demonstrated through phylogenetic and expression pattern analyses. This study provides important insights for future investigations on the functionality of WAK genes.
PLANT CELL REPORTS
(2023)
Article
Geosciences, Multidisciplinary
M. Persson, Y. Futaana, R. Ramstad, A. Schillings, K. Masunaga, H. Nilsson, A. Fedorov, S. Barabash
Summary: Research indicates that an important process of losing water in Venusian atmosphere is due to the energy and momentum transfer from the solar wind to atmospheric particles. Furthermore, under the Venusian induced magnetosphere, only an average of 0.01% of available power is transferred through oxygen ion escape, with the percentage decreasing as available energy increases.
GEOPHYSICAL RESEARCH LETTERS
(2021)
Article
Multidisciplinary Sciences
Hongyan Han, Xiaopeng Mu, Pengfei Wang, Zewen Wang, Hongbo Fu, Yu Gary Gao, Junjie Du
Summary: LecRLK receptor-like protein kinases have been found to play a role in plants' responses to various stress factors. The study identified 170 LecRLK family genes in Cerasus humilis and found that nine representative genes were actively involved in salt and drought stress responses. These results provide a foundation for future functional verification of these genes and may facilitate the development of new stress-resistant Cerasus humilis cultivars.
Article
Biochemistry & Molecular Biology
Chathura D. Suraweera, Suresh Banjara, Mark G. Hinds, Marc Kvansakul
Summary: The B-cell lymphoma-2 (Bcl-2) family of genes regulates intrinsic apoptosis by coordinating the integrity of the mitochondrial outer membrane. Bcl-2 genes are present in early metazoans and have different variations among species. The structure of Bcl-2 proteins is highly conserved over evolutionary time, and some Bcl-2 proteins may have non-apoptotic functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Audrey A. Burnim, Da Xu, Matthew A. Spence, Colin J. Jackson, Nozomi Ando
Summary: Ribonucleotide reductases (RNRs) are essential enzymes for DNA synthesis in all organisms. This study reveals the evolutionary relationships within the RNR family and identifies structurally similar domains and insertions with similar functions. These findings are important for understanding the diversification of the RNR family.
Review
Astronomy & Astrophysics
Arnaud Salvador, Guillaume Avice, Doris Breuer, Cedric Gillmann, Helmut Lammer, Emmanuel Marcq, Sean N. Raymond, Haruka Sakuraba, Manuel Scherf, M. J. Way
Summary: The current state and surface conditions of Earth and Venus differ greatly, with water playing a key role in these differences. This chapter reviews the outcomes of the accretion sequence and discusses the early thermo-chemical evolution of molten terrestrial planets and its impact on the abundance and distribution of water. The implications of these findings for the surface conditions and habitability are discussed, and future research directions and observations are proposed to further understand the evolution of Venus.
SPACE SCIENCE REVIEWS
(2023)
Review
Neurosciences
Mark L. Mayer
Summary: The research by Watkins and colleagues has played a crucial role in our understanding of excitatory synaptic transmission in the central nervous system of animals; recent studies have revealed unexpected ligand binding profiles for newly identified glutamate receptors; structural studies indicate that the biology of glutamate receptors is more complex than initially anticipated.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Materials Science, Multidisciplinary
Ram Prakash Pandeya, Anup Pradhan Sakhya, Sawani Datta, Tanusree Saha, Giovanni De Ninno, Rajib Mondal, C. Schlueter, A. Gloskovskii, Paolo Moras, Matteo Jugovac, Carlo Carbone, A. Thamizhavel, Kalobaran Maiti
Summary: The study reveals the presence of coupling among conduction electrons in the core level spectra of the superconductor CaFe1.9Co0.1As2, with features evolving with cooling. This highlights the importance of such interactions in Fe-based systems and their relevance to unconventional superconductivity.
Article
Biochemistry & Molecular Biology
Zhiqiang Zhang, Wenyu Ma, Zhongying Ren, Xingxing Wang, Junjie Zhao, Xiaoyu Pei, Yangai Liu, Kunlun He, Fei Zhang, Wenqi Huo, Wei Li, Daigang Yang, Xiongfeng Ma
Summary: Expansion of the WAK/WAKL gene family in cotton is mainly due to segmental and tandem duplications, and the family has been subjected to purifying selection pressure during evolution. The functions of WAK/WAKL genes in cotton are conserved, with their promoters responsive to multiple phytohormones and abiotic stresses, and the genes induced by various abiotic stresses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Steven De Munck, Mathias Provost, Michiko Kurikawa, Ikuko Omori, Junko Mukohyama, Jan Felix, Yehudi Bloch, Omar Abdel-Wahab, J. Fernando Bazan, Akihide Yoshimi, Savvas N. Savvides
Summary: ALK and LTK are recently identified receptor tyrosine kinases involved in neural development, cancer, and autoimmune diseases, along with their activating cytokines ALKAL1 and ALKAL2. Structural studies reveal a unique architecture of the cytokine-binding segments, and propose a mechanistic blueprint for the complexes of ALK family receptors.
Article
Chemistry, Multidisciplinary
Philipp Leippe, Johannes Broichhagen, Katia Cailliau, Alexandra Mougel, Marion Morel, Colette Dissous, Dirk Trauner, Jerome Vicogne
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Biochemistry & Molecular Biology
Marion Morel, Krushangi N. Shah, Weiwen Long
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Vincent Diemer, Nathalie Ollivier, Berenice Leclercq, Herve Drobecq, Jerome Vicogne, Vangelis Agouridas, Oleg Melnyk
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Adnan Hodzic, Lourdes Mateos-Hernandez, Emilie Frealle, Patricia Roman-Carrasco, Pilar Alberdi, Muriel Pichavant, Veronica Risco-Castillo, Delphine Le Roux, Jerome Vicogne, Wolfgang Hemmer, Herbert Auer, Ines Swoboda, Georg Gerhard Duscher, Jose de la Fuente, Alejandro Cabezas-Cruz
Article
Chemistry, Organic
Nathalie Ollivier, Vangelis Agouridas, Benoit Snella, Remi Desmet, Herve Drobecq, Jerome Vicogne, Oleg Melnyk
Article
Biology
Nadege Gouignard, Eric Theveneau, Jean-Pierre Saint-Jeannet
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Article
Oncology
Sreeram Vallabhaneni, Jian Liu, Marion Morel, Jixin Wang, Francesco J. DeMayo, Weiwen Long
Summary: ERK3, a poorly studied mitogen-activated protein kinase, has been shown to be upregulated in cancer, particularly promoting lung cancer cell growth and invasion. Using genetically engineered mouse models, the study revealed that ERK3 acts as an oncoprotein in promoting lung adenocarcinoma development and progression.
MOLECULAR ONCOLOGY
(2022)
Article
Infectious Diseases
Lucile Pagliazzo, Stephanie Caby, Julien Lancelot, Sophie Salome-Desnoulez, Jean-Michel Saliou, Tino Heimburg, Thierry Chassat, Katia Cailliau, Wolfgang Sippl, Jerome Vicogne, Raymond J. Pierce
Summary: The study validated the interaction between histone deacetylase 8 and SmRho1, shedding light on its role in cytoskeletal regulation.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Chemistry, Multidisciplinary
Benoit Snella, Benjamin Grain, Jerome Vicogne, Frederic Capet, Birgit Wiltschi, Oleg Melnyk, Vangelis Agouridas
Summary: Latent oxalyl thioester surrogates are a powerful tool for modifying peptides and proteins in diluted conditions. They are designed to be stable and can be activated on demand for ligation reactions with peptide concentrations as low as a few hundred nM at high rates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Alexandra Mougel, Eric Adriaenssens, Boris Guyot, Lu Tian, Stephanie Gobert, Thierry Chassat, Philippe Persoons, David Hannebique, Helene Bauderlique-Le Roy, Jerome Vicogne, Xuefen Le Bourhis, Roland P. Bourette
Summary: This study investigates the functionality of the CSF-1 receptor in prostate cancer cells and discovers that it can activate multiple signaling pathways and promote cell growth and invasion. They also find that activation of the CSF-1 receptor increases the expression of osteopontin, a key player in cancer development and metastasis. Therefore, the CSF-1 receptor may be a potential therapeutic target for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Vincent Girod, Robin Houssier, Karin Sahmer, Marie-Jose Ghoris, Stephanie Caby, Oleg Melnyk, Colette Dissous, Vincent Senez, Jerome Vicogne
Summary: This study reports a self-purifying microfluidic system that can select healthy adult worms and quickly identify molecules that act on schistosomiasis. This system allows for faster and more sensitive detection of antischistosomal compounds.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Cell Biology
Amanda K. Myers, Marion Morel, Stephen H. Gee, Katherine A. Hoffmann, Weiwen Long
Summary: ERK3 promotes lung cancer cell migration and metastasis by binding to DGK?, while DGK? suppresses ERK3-mediated cell motility by competing for binding sites.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marco Maccarana, Emil Tykesson, Edgar M. Pera, Nadege Gouignard, Jianping Fang, Anders Malmstrom, Giancarlo Ghiselli, Jin-ping Li
Summary: Ebselen was identified as a potent inhibitor of enzymes producing iduronic acid in CS/DS and HS, reducing the accumulation of CS/DS and promoting GAG degradation in MPS-I fibroblasts. While it failed to ameliorate the burden in MPS-I mice, the study suggests a potential for iduronic acid substrate reduction therapy for MPS-I patients.
Article
Multidisciplinary Sciences
Nadege Gouignard, Floriane Cherrier, Emma Brito-Fravallo, Adrien Pain, Natalia Marta Zmarlak, Katia Cailliau, Corinne Geneve, Kenneth D. Vernick, Colette Dissous, Christian Mitri
SCIENTIFIC REPORTS
(2019)