Partial Agonist, Telmisartan, Maintains PPARγ Serine 112 Phosphorylation, and Does Not Affect Osteoblast Differentiation and Bone Mass

Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton

(2013) Sima Rahman et al.   ENDOCRINOLOGY

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Telmisartan at 80 mg/Day Increases High-Molecular-Weight Adiponectin Levels and Improves Insulin Resistance in Diabetic Patients

(2012) Hiroko Mori et al.   ADVANCES IN THERAPY

Involvement of the Skeletal Renin-Angiotensin System in Age-Related Osteoporosis of Ageing Mice

(2012) Sa-sa GU et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Rosiglitazone disrupts endosteal bone formation during distraction osteogenesis by local adipocytic infiltration

(2012) Lichu Liu et al.   BONE

Rosiglitazone Inhibits Bone Regeneration and Causes Significant Accumulation of Fat at Sites of New Bone Formation

(2012) Lichu Liu et al.   CALCIFIED TISSUE INTERNATIONAL

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Activation of AMPK–Sirt1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects

(2012) Asuka Shiota et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Histologic identification of brown adipose and peripheral nerve involvement in human atherosclerotic vessels

(2012) Elizabeth Salisbury et al.   HUMAN PATHOLOGY

Structural basis for telmisartan-mediated partial activation of PPAR gamma

(2012) Yasushi Amano et al.   HYPERTENSION RESEARCH

β-Catenin Directly Sequesters Adipocytic and Insulin Sensitizing Activities but Not Osteoblastic Activity of PPARγ2 in Marrow Mesenchymal Stem Cells

(2012) Sima Rahman et al.   PLoS One

Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism

(2011) William P. Cawthorn et al.   BONE

The Heparin-binding Domain of IGFBP-2 Has Insulin-like Growth Factor Binding-independent Biologic Activity in the Growing Skeleton

(2011) Masanobu Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Phosphatase 5 Mediates Lipid Metabolism through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-activated Receptor-γ (PPARγ)

(2011) Terry D. Hinds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Decreased osteoclastogenesis and high bone mass in mice with impaired insulin clearance due to liver-specific inactivation to CEACAM1

(2010) S. Huang et al.   BONE

Telmisartan alleviates rosiglitazone-induced bone loss in ovariectomized spontaneous hypertensive rats

(2010) L. Ma et al.   BONE

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

(2010) Kristina Hedbacker et al.   Cell Metabolism

The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

(2010) Jan Nedergaard et al.   Cell Metabolism

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Telmisartan ameliorates hyperglycemia and metabolic profile in nonobese Cohen-Rosenthal diabetic hypertensive rats via peroxisome proliferator activator receptor–γ activation

(2010) Firas Younis et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis

(2010) Beata Lecka-Czernik   Current Osteoporosis Reports

Chronic treatment with angiotensin AT1 receptor antagonists reduced serum but not bone TGF-β1 levels in ovariectomized rats

(2009) Yong-Qi Li et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

A Selective Peroxisome Proliferator-Activated Receptor-γ Modulator, Telmisartan, Binds to the Receptor in a Different Fashion from Thiazolidinediones

(2009) Tetsuya Tagami et al.   ENDOCRINOLOGY

PPARγ2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells

(2009) Keith R. Shockley et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Angiotensin inhibition stimulates PPARγ and the release of visfatin

(2008) A. Storka et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Angiotensin II accelerates osteoporosis by activating osteoclasts

(2008) Hideo Shimizu et al.   FASEB JOURNAL

Angiotensin II Type 2 Receptor Blockade Increases Bone Mass

(2008) Yayoi Izu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The use of nanoindentation for characterizing the properties of mineralized hard tissues: State-of-the art review

(2008) Gladius Lewis et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Activation of Renin–Angiotensin System Induces Osteoporosis Independently of Hypertension

(2008) Yutaro Asaba et al.   JOURNAL OF BONE AND MINERAL RESEARCH