MicroRNA Mechanisms of Action: What have We Learned from Mice?

Transgene-derived overexpression of miR-17-92 in CD8+ T-cells confers enhanced cytotoxic activity

(2015) Akemi Kosaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression and knockout of miR-126 both promote leukemogenesis

(2015) Z. Li et al.   BLOOD

Altered lymphopoiesis and immunodeficiency in miR-142 null mice

(2015) N. J. Kramer et al.   BLOOD

miRNA-204 drives cardiomyocyte proliferation via targeting Jarid2

(2015) Dandan Liang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4

(2015) Kai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mature T cell responses are controlled by microRNA-142

(2015) Yaping Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation

(2015) Chang-Jun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-15/16 AntagonizesMybTo Control NK Cell Maturation

(2015) Ryan P. Sullivan et al.   JOURNAL OF IMMUNOLOGY

Outside the coding genome, mammalian microRNAs confer structural and functional complexity

(2015) Virginie Olive et al.   Science Signaling

The utility of protein and mRNA correlation

(2015) Samuel H. Payne   TRENDS IN BIOCHEMICAL SCIENCES

NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis

(2015) Sha Yan et al.   Nature Communications

Mir-17–92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c

(2015) Shengli Xu et al.   Nature Communications

MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3

(2015) Lingyun Zhang et al.   Nature Communications

Mir-17∼92 Governs Motor Neuron Subtype Survival by Mediating Nuclear PTEN

(2015) Ying-Tsen Tung et al.   Cell Reports

miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability

(2015) Ronald J. Parchem et al.   Cell Reports

Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature

(2015) Leah Cushing et al.   PLoS Genetics

Outside the coding genome, mammalian microRNAs confer structural and functional complexity

(2015) Virginie Olive et al.   Science Signaling

mir-34b/c and mir-449a/b/c are required for spermatogenesis, but not for the first cleavage division in mice

(2015) S. Yuan et al.   Biology Open

Transfection of microRNA Mimics Should Be Used with Caution

(2015) Hyun Yong Jin et al.   Frontiers in Genetics

Induction of angiotensin-converting enzyme after miR-143/145 deletion is critical for impaired smooth muscle contractility

(2014) Diana Dahan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MiR-146a regulates the TRAF6/TNF-axis in donor T cells during GVHD

(2014) N. Stickel et al.   BLOOD

Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation

(2014) M. L. Burger et al.   BLOOD

miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury

(2014) K Wang et al.   CELL DEATH AND DIFFERENTIATION

Multifaceted roles of miR-1s in repressing the fetal gene program in the heart

(2014) Yusheng Wei et al.   CELL RESEARCH

miR-155 Activates Cytokine Gene Expression in Th17 Cells by Regulating the DNA-Binding Protein Jarid2 to Relieve Polycomb-Mediated Repression

(2014) Thelma M. Escobar et al.   IMMUNITY

miR-155 Promotes T Follicular Helper Cell Accumulation during Chronic, Low-Grade Inflammation

(2014) Ruozhen Hu et al.   IMMUNITY

MicroRNA-155 deficiency enhances the recruitment and functions of myeloid-derived suppressor cells in tumor microenvironment and promotes solid tumor growth

(2014) Junfeng Wang et al.   INTERNATIONAL JOURNAL OF CANCER

miR-17-92 Cluster Targets Phosphatase and Tensin Homology and Ikaros Family Zinc Finger 4 to Promote TH17-mediated Inflammation

(2014) Si-Qi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway

(2014) Mohammed I. Ahmed et al.   JOURNAL OF CELL BIOLOGY

MicroRNA-7a regulates pancreatic β cell function

(2014) Mathieu Latreille et al.   JOURNAL OF CLINICAL INVESTIGATION

The miR-155–PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation

(2014) Dong Lu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110

(2014) Rui Song et al.   NATURE

miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

(2014) Jing Y. Krzeszinski et al.   NATURE

Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210

(2014) Haopeng Wang et al.   NATURE IMMUNOLOGY

MicroRNA-378 controls classical brown fat expansion to counteract obesity

(2014) Dongning Pan et al.   Nature Communications

miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis

(2014) Elik Chapnik et al.   eLife

MicroRNA-9 controls dendritic development by targeting REST

(2014) Sebastian A Giusti et al.   eLife

Forced miR-146a expression causes autoimmune lymphoproliferative syndrome in mice via downregulation of Fas in germinal center B cells

(2013) Q. Guo et al.   BLOOD

MicroRNA-17 92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections

(2013) A. A. Khan et al.   BLOOD

The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation

(2013) Su Jung Song et al.   Cell Stem Cell

The MicroRNA miR-181 Is a Critical Cellular Metabolic Rheostat Essential for NKT Cell Ontogenesis and Lymphocyte Development and Homeostasis

(2013) Jorge Henao-Mejia et al.   IMMUNITY

MicroRNA-155 Is Required for Effector CD8+ T Cell Responses to Virus Infection and Cancer

(2013) Jan C. Dudda et al.   IMMUNITY

An Androgen Receptor-MicroRNA-29a Regulatory Circuitry in Mouse Epididymis

(2013) Wubin Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic Expression of MicroRNA-185 Causes a Developmental Arrest of T Cells by Targeting Multiple Genes IncludingMzb1

(2013) Serkan Belkaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment

(2013) Anca Dorhoi et al.   JOURNAL OF CLINICAL INVESTIGATION

MiR-210 Is Induced by Oct-2, Regulates B Cells, and Inhibits Autoantibody Production

(2013) Y. Mok et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway

(2013) Dongmei Wang et al.   NATURE CELL BIOLOGY

The miR-126–VEGFR2 axis controls the innate response to pathogen-associated nucleic acids

(2013) Judith Agudo et al.   NATURE IMMUNOLOGY

Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1

(2013) Christoph A Gebeshuber et al.   NATURE MEDICINE

MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice

(2013) C. L. Tan et al.   SCIENCE

MiR-200b and miR-429 Function in Mouse Ovulation and Are Essential for Female Fertility

(2013) H. Hasuwa et al.   SCIENCE

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice

(2013) Takahiro Horie et al.   Nature Communications

MicroRNA Cluster miR-17-92 Regulates Neural Stem Cell Expansion and Transition to Intermediate Progenitors in the Developing Mouse Neocortex

(2013) Shan Bian et al.   Cell Reports

miR-1/133a Clusters Cooperatively Specify the Cardiomyogenic Lineage by Adjustment of Myocardin Levels during Embryonic Heart Development

(2013) Katharina Wystub et al.   PLoS Genetics

Loss of miR-10a Activates Lpo and Collaborates with Activated Wnt Signaling in Inducing Intestinal Neoplasia in Female Mice

(2013) Gustavo Stadthagen et al.   PLoS Genetics

microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart

(2013) Amy Heidersbach et al.   eLife

MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice

(2013) Takahiro Horie et al.   Journal of the American Heart Association

A Novel Regulator of Macrophage Activation

(2012) Guoqing Zhuang et al.   CIRCULATION

Targeted Deletion of MicroRNA-22 Promotes Stress-Induced Cardiac Dilation and Contractile Dysfunction

(2012) Priyatansh Gurha et al.   CIRCULATION

A Role for miR-145 in Pulmonary Arterial Hypertension

(2012) Paola Caruso et al.   CIRCULATION RESEARCH

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

(2012) Julien Béthune et al.   EMBO REPORTS

Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis

(2012) Laura S. Danielson et al.   FASEB JOURNAL

Quantitative functions of Argonaute proteins in mammalian development

(2012) D. Wang et al.   GENES & DEVELOPMENT

Liver tumorigenicity promoted by microRNA-221 in a mouse transgenic model

(2012) Elisa Callegari et al.   HEPATOLOGY

miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2

(2012) Jianwen Wei et al.   JOURNAL OF CELL BIOLOGY

MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death

(2012) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

(2012) Shu-hao Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice

(2012) Ning Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

(2012) Wei-Chih Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-214 targets ATF4 to inhibit bone formation

(2012) Xiaogang Wang et al.   NATURE MEDICINE

Alternative RISC assembly: Binding and repression of microRNA-mRNA duplexes by human Ago proteins

(2012) M. M. Janas et al.   RNA

Coat color determination by miR-137 mediated down-regulation of microphthalmia-associated transcription factor in a mouse model

(2012) C. Dong et al.   RNA

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

(2012) A. A. Bazzini et al.   SCIENCE

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy

(2012) Ahmet Ucar et al.   Nature Communications

Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells

(2012) Masaki Mori et al.   PLOS BIOLOGY

Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation

(2011) S. Jiang et al.   BLOOD

Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function

(2011) I. Dunand-Sauthier et al.   BLOOD

MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2

(2011) Chunlian Liang et al.   BRAIN RESEARCH

Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy

(2011) Ning Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors

(2011) M. Shibata et al.   JOURNAL OF NEUROSCIENCE

Chondrocyte-Specific MicroRNA-140 Regulates Endochondral Bone Development and Targets Dnpep To Modulate Bone Morphogenetic Protein Signaling

(2011) Y. Nakamura et al.   MOLECULAR AND CELLULAR BIOLOGY

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

(2011) Sabine D. Jordan et al.   NATURE CELL BIOLOGY

Epithelial microRNAs regulate gut mucosal immunity via epithelium–T cell crosstalk

(2011) Moshe Biton et al.   NATURE IMMUNOLOGY

miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression

(2011) Rikako Sanuki et al.   NATURE NEUROSCIENCE

Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis

(2011) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3 

(2010) D. M. Patrick et al.   GENES & DEVELOPMENT

miR-451 protects against erythroid oxidant stress by repressing 14-3-3 

(2010) D. Yu et al.   GENES & DEVELOPMENT

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

Regulation of MicroRNA Expression and Abundance during Lymphopoiesis

(2010) Stefan Kuchen et al.   IMMUNITY

MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development

(2010) Ryan M. O'Connell et al.   IMMUNITY

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

MicroRNA-133a Protects Against Myocardial Fibrosis and Modulates Electrical Repolarization Without Affecting Hypertrophy in Pressure-Overloaded Adult Hearts

(2009) Scot J. Matkovich et al.   CIRCULATION RESEARCH

MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury

(2009) M. Xin et al.   GENES & DEVELOPMENT

Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

(2009) Li-Fan Lu et al.   IMMUNITY

Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster

(2009) Thomas Boettger et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice

(2009) Thomas E. Callis et al.   JOURNAL OF CLINICAL INVESTIGATION

Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

(2009) Sung Wook Chi et al.   NATURE

MicroRNA MiR-17 retards tissue growth and represses fibronectin expression

(2009) Sze Wan Shan et al.   NATURE CELL BIOLOGY

Inositol phosphatase SHIP1 is a primary target of miR-155

(2009) R. M. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-375 maintains normal pancreatic  - and  -cell mass

(2009) M. N. Poy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice

(2009) A. H. Williams et al.   SCIENCE

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart

(2008) N. Liu et al.   GENES & DEVELOPMENT

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

(2008) Yair Dorsett et al.   IMMUNITY