Outside the coding genome, mammalian microRNAs confer structural and functional complexity

The biological functions of miRNAs: lessons from in vivo studies

(2015) Joana A. Vidigal et al.   TRENDS IN CELL BIOLOGY

An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration

(2014) Raghu R. Chivukula et al.   CELL

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

(2014) Thomas R. Cech et al.   CELL

MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex

(2014) Tian-Lin Cheng et al.   DEVELOPMENTAL CELL

The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration

(2014) B. K. Dey et al.   GENES & DEVELOPMENT

Regulation of pri-miRNA Processing by a Long Noncoding RNA Transcribed from an Ultraconserved Region

(2014) Julia Liz et al.   MOLECULAR CELL

miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110

(2014) Rui Song et al.   NATURE

miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

(2014) Jing Y. Krzeszinski et al.   NATURE

Rbfox3 controls the biogenesis of a subset of microRNAs

(2014) Kee K Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phenotypic Characterization of miR-92a−/− Mice Reveals an Important Function of miR-92a in Skeletal Development

(2014) Daniela Penzkofer et al.   PLoS One

Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis

(2014) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lin28a regulates neuronal differentiation and controls miR-9 production

(2014) Jakub S. Nowak et al.   Nature Communications

Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation

(2014) Nila Roy Choudhury et al.   Cell Reports

ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing

(2013) Hiromitsu Ota et al.   CELL

The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation

(2013) H. Cao et al.   DEVELOPMENT

Regulation of miR-17-92a cluster processing by the microRNA binding protein SND1

(2013) Eva-Marie Heinrich et al.   FEBS LETTERS

LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7

(2013) B. B. Madison et al.   GENES & DEVELOPMENT

Tissue-specific control of brain-enriched miR-7 biogenesis

(2013) N. R. Choudhury et al.   GENES & DEVELOPMENT

MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway

(2013) Dongmei Wang et al.   NATURE CELL BIOLOGY

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-21 Knockout Improve the Survival Rate in DSS Induced Fatal Colitis through Protecting against Inflammation and Tissue Injury

(2013) Chenzhang Shi et al.   PLoS One

miR-132/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity

(2013) Judit Remenyi et al.   PLoS One

microRNA-22 Promotes Heart Failure through Coordinate Suppression of PPAR/ERR-Nuclear Hormone Receptor Transcription

(2013) Priyatansh Gurha et al.   PLoS One

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration

(2013) S. Lumayag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice

(2013) C. L. Tan et al.   SCIENCE

MiR-200b and miR-429 Function in Mouse Ovulation and Are Essential for Female Fertility

(2013) H. Hasuwa et al.   SCIENCE

Signaling by p38 MAPK Stimulates Nuclear Localization of the Microprocessor Component p68 for Processing of Selected Primary MicroRNAs

(2013) S. Hong et al.   Science Signaling

miR-1/133a Clusters Cooperatively Specify the Cardiomyogenic Lineage by Adjustment of Myocardin Levels during Embryonic Heart Development

(2013) Katharina Wystub et al.   PLoS Genetics

Loss of miR-10a Activates Lpo and Collaborates with Activated Wnt Signaling in Inducing Intestinal Neoplasia in Female Mice

(2013) Gustavo Stadthagen et al.   PLoS Genetics

A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis

(2013) Virginie Olive et al.   eLife

microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart

(2013) Amy Heidersbach et al.   eLife

MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice

(2013) Jimmy L Zhao et al.   eLife

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

Human RNA Methyltransferase BCDIN3D Regulates MicroRNA Processing

(2012) Blerta Xhemalce et al.   CELL

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Mono-Uridylation of Pre-MicroRNA as a Key Step in the Biogenesis of Group II let-7 MicroRNAs

(2012) Inha Heo et al.   CELL

Targeted Deletion of MicroRNA-22 Promotes Stress-Induced Cardiac Dilation and Contractile Dysfunction

(2012) Priyatansh Gurha et al.   CIRCULATION

MicroRNAs 221 and 222 regulate the undifferentiated state in mammalian male germ cells

(2012) Q.-E. Yang et al.   DEVELOPMENT

STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA

(2012) A.-J. Chen et al.   GENES & DEVELOPMENT

MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway

(2012) Jianqiang Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex

(2012) Shinji Kawai et al.   JOURNAL OF CELL BIOLOGY

MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death

(2012) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-122 regulates hepatic lipid metabolism and tumor suppression

(2012) Jessica Wen et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

(2012) Shu-hao Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

(2012) Wei-Chih Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-29ab1 Deficiency Identifies a Negative Feedback Loop Controlling Th1 Bias That Is Dysregulated in Multiple Sclerosis

(2012) K. M. Smith et al.   JOURNAL OF IMMUNOLOGY

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Architecture of the human regulatory network derived from ENCODE data

(2012) Mark B. Gerstein et al.   NATURE

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

(2012) Y. Kawahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pri-miR-17-92a transcript folds into a tertiary structure and autoregulates its processing

(2012) S. Chakraborty et al.   RNA

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

A Resource for the Conditional Ablation of microRNAs in the Mouse

(2012) Chong Yon Park et al.   Cell Reports

Intact p53-Dependent Responses in miR-34–Deficient Mice

(2012) Carla P. Concepcion et al.   PLoS Genetics

Modulating the Strength and Threshold of NOTCH Oncogenic Signals by mir-181a-1/b-1

(2012) Rita Fragoso et al.   PLoS Genetics

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system

(2011) Rui Tang et al.   CELL RESEARCH

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors

(2011) M. Shibata et al.   JOURNAL OF NEUROSCIENCE

MCPIP1 Ribonuclease Antagonizes Dicer and Terminates MicroRNA Biogenesis through Precursor MicroRNA Degradation

(2011) Hiroshi I. Suzuki et al.   MOLECULAR CELL

Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

(2011) Brice Marcet et al.   NATURE CELL BIOLOGY

miR-34 miRNAs provide a barrier for somatic cell reprogramming

(2011) Yong Jin Choi et al.   NATURE CELL BIOLOGY

Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans

(2011) Loïc de Pontual et al.   NATURE GENETICS

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

(2011) Aikaterini S Papadopoulou et al.   NATURE IMMUNOLOGY

miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression

(2011) Rikako Sanuki et al.   NATURE NEUROSCIENCE

Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy

(2011) Frédérique Rau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Widespread Regulation of miRNA Biogenesis at the Dicer Step by the Cold-Inducible RNA-Binding Protein, RBM3

(2011) Julie Pilotte et al.   PLoS One

NF- B dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies

(2011) J. L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects

(2011) L. A. Medeiros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of pri-miRNA tertiary structure in miR-17~92 miRNA biogenesis

(2011) Steven G Chaulk et al.   RNA Biology

Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles

(2011) A. Jouneau et al.   RNA

Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells

(2010) C. Doebele et al.   BLOOD

The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia

(2010) Ulf Klein et al.   CANCER CELL

The miR-17-92 Cluster of MicroRNAs Confers Tumorigenicity by Inhibiting Oncogene-Induced Senescence

(2010) L. Hong et al.   CANCER RESEARCH

Many Families of C. elegans MicroRNAs Are Not Essential for Development or Viability

(2010) Ezequiel Alvarez-Saavedra et al.   CURRENT BIOLOGY

Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3 

(2010) D. M. Patrick et al.   GENES & DEVELOPMENT

Emerging paradigms of regulated microRNA processing

(2010) M. A. Newman et al.   GENES & DEVELOPMENT

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

mir-17-92, a cluster of miRNAs in the midst of the cancer network

(2010) Virginie Olive et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The miR-144/451 locus is required for erythroid homeostasis

(2010) Kasper D. Rasmussen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Splicing-Independent Function of SF2/ASF in MicroRNA Processing

(2010) Han Wu et al.   MOLECULAR CELL

miR-122 Continues to Blaze the Trail for MicroRNA Therapeutics

(2010) Dirk Haussecker et al.   MOLECULAR THERAPY

A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

(2010) Martijn Kedde et al.   NATURE CELL BIOLOGY

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis

(2010) Gracjan Michlewski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo

(2010) T. Horie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease

(2009) L Elia et al.   CELL DEATH AND DIFFERENTIATION

Loss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure

(2009) Prakash K. Rao et al.   CIRCULATION RESEARCH

Integration of microRNA miR-122 in hepatic circadian gene expression

(2009) D. Gatfield et al.   GENES & DEVELOPMENT

MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury

(2009) M. Xin et al.   GENES & DEVELOPMENT

miR-19 is a key oncogenic component of mir-17-92

(2009) V. Olive et al.   GENES & DEVELOPMENT

Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster

(2009) Thomas Boettger et al.   JOURNAL OF CLINICAL INVESTIGATION

The NF90-NF45 Complex Functions as a Negative Regulator in the MicroRNA Processing Pathway

(2009) S. Sakamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

Modulation of microRNA processing by p53

(2009) Hiroshi I. Suzuki et al.   NATURE

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

(2009) Michele Trabucchi et al.   NATURE

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

(2009) Kimberly R. Cordes et al.   NATURE

Biogenesis of small RNAs in animals

(2009) V. Narry Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

miR-375 maintains normal pancreatic  - and  -cell mass

(2009) M. N. Poy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice

(2009) A. Bonauer et al.   SCIENCE

MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice

(2009) A. H. Williams et al.   SCIENCE

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Highly Dynamic and Sex-Specific Expression of microRNAs During Early ES Cell Differentiation

(2009) Constance Ciaudo et al.   PLoS Genetics

A Feed-Forward Loop Involving Protein Kinase C  and MicroRNAs Regulates Tumor Cell Cycle

(2008) E. E.W. Cohen et al.   CANCER RESEARCH

miRiad Roles for the miR-17-92 Cluster in Development and Disease

(2008) Joshua T. Mendell   CELL

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

(2008) Andrea Ventura et al.   CELL

MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells

(2008) Kathryn N. Ivey et al.   Cell Stem Cell

Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126

(2008) F. Kuhnert et al.   DEVELOPMENT

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart

(2008) N. Liu et al.   GENES & DEVELOPMENT

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

(2008) J. E. Babiarz et al.   GENES & DEVELOPMENT

Posttranscriptional Regulation of miRNAs Harboring Conserved Terminal Loops

(2008) Gracjan Michlewski et al.   MOLECULAR CELL

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

(2008) Jonathan B. Johnnidis et al.   NATURE

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis

(2008) B. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration

(2008) T. L. Cuellar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY