Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity

A novel PGC-1α isoform in brain localizes to mitochondria and associates with PINK1 and VDAC

(2013) Joungil Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons

(2013) Ruishan Wang et al.   Cell Metabolism

Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes

(2013) Anna Biason-Lauber et al.   Cell Metabolism

Glucose Levels and Risk of Dementia

(2013) Paul K. Crane et al.   NEW ENGLAND JOURNAL OF MEDICINE

A community-based approach to trials of aerobic exercise in aging and Alzheimer's disease

(2012) Eric D. Vidoni et al.   Contemporary Clinical Trials

Extranuclear Localization of SIRT1 and PGC-1α: An Insight into Possible Roles in Diseases Associated with Mitochondrial Dysfunction

(2012) K. Aquilano et al.   CURRENT MOLECULAR MEDICINE

A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset†

(2012) Selma M. Soyal et al.   HUMAN MOLECULAR GENETICS

Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes

(2012) Lucy M Hinder et al.   JOURNAL OF ENDOCRINOLOGY

Selective breeding for endurance running capacity affects cognitive but not motor learning in rats

(2012) Jan Wikgren et al.   PHYSIOLOGY & BEHAVIOR

A Rat Model System to Study Complex Disease Risks, Fitness, Aging, and Longevity

(2012) Lauren Gerard Koch et al.   TRENDS IN CARDIOVASCULAR MEDICINE

SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells

(2012) Reas S. Khan et al.   Frontiers in Cellular Neuroscience

Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes

(2011) Anders H Olsson et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Early Microstructural and Metabolic Changes following Controlled Cortical Impact Injury in Rat: A Magnetic Resonance Imaging and Spectroscopy Study

(2011) Su Xu et al.   JOURNAL OF NEUROTRAUMA

High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal

(2011) Seán M Kilbride et al.   Molecular Neurodegeneration

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

(2011) Mali Jiang et al.   NATURE MEDICINE

Truncated Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α Splice Variant Is Severely Altered in Huntington’s Disease

(2011) Ashu Johri et al.   Neurodegenerative Diseases

Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity

(2010) Constance Tweedie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria

(2010) Katia Aquilano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The link between iron, metabolic syndrome, and Alzheimer’s disease

(2010) Edna Grünblatt et al.   JOURNAL OF NEURAL TRANSMISSION

Prefrontal and hippocampal contributions to encoding and retrieval of spatial memory

(2010) John C. Churchwell et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI

(2010) G. A. Kerchner et al.   NEUROLOGY

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

(2009) Gary E. Gibson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury

(2009) John P. Thyfault et al.   JOURNAL OF PHYSIOLOGY-LONDON

Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2009) Yazi D. Ke et al.   PLoS One

Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability

(2008) G. Ramadori et al.   JOURNAL OF NEUROSCIENCE

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

(2008) Judith Miklossy et al.   NEUROBIOLOGY OF AGING