Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells

Fighting breast cancer stem cells through the immune-targeting of the xCT cystine–glutamate antiporter

(2018) Roberto Ruiu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Overexpression of SLC7A11: a novel oncogene and an indicator of unfavorable prognosis for liver carcinoma

(2018) Liang Zhang et al.   Future Oncology

Expression of the MHC class II in triple-negative breast cancer is associated with tumor-infiltrating lymphocytes and interferon signaling

(2017) In Ah Park et al.   PLoS One

Cancer stem cells: The root of tumor recurrence and metastases

(2017) Claudia Peitzsch et al.   SEMINARS IN CANCER BIOLOGY

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility

(2017) Chun-Shik Shin et al.   Nature Communications

The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis

(2017) Federica Fusella et al.   Nature Communications

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells

(2017) Emmanuel Dornier et al.   Nature Communications

Cell-surface marker discovery for lung cancer

(2017) Allison S. Cohen et al.   Oncotarget

Induction of Antihuman C–C Chemokine Receptor Type 5 Antibodies by a Bovine Herpesvirus Type-4 Based Vector

(2017) Andrea Elizabeth Verna et al.   Frontiers in Immunology

CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function

(2017) Arata Takeuchi et al.   Frontiers in Immunology

A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo

(2017) Elisabetta Bolli et al.   OncoImmunology

NK cells control breast cancer and related cancer stem cell hematological spread

(2017) Rossana Tallerico et al.   OncoImmunology

Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability

(2016) Laura R. de la Ballina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annual Hazard Rates of Recurrence for Breast Cancer During 24 Years of Follow-Up: Results From the International Breast Cancer Study Group Trials I to V

(2016) Marco Colleoni et al.   JOURNAL OF CLINICAL ONCOLOGY

Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance

(2016) In-geun Ryoo et al.   Oxidative Medicine and Cellular Longevity

Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells

(2016) Masanori Hasegawa et al.   Oncotarget

L-Ferritin targets breast cancer stem cells and delivers therapeutic and imaging agents

(2016) Laura Conti et al.   Oncotarget

Is there a role for therapeutic cancer vaccines in the age of checkpoint inhibitors?

(2016) Robert O. Dillman   Human Vaccines & Immunotherapeutics

The non-inflammatory role of C1q during Her2/neu-driven mammary carcinogenesis

(2016) Silvio Bandini et al.   OncoImmunology

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

(2015) Ming-zhe Ma et al.   CANCER LETTERS

Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer

(2015) S. Lanzardo et al.   CANCER RESEARCH

Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells

(2015) S. Geninatti Crich et al.   Nanoscale

Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function

(2015) LIANGYU CHEN et al.   ONCOLOGY REPORTS

Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

(2015) Haiquan Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain

(2015) Jennifer Fazzari et al.   Scientific Reports

BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-/-) Mice from Monkeypoxvirus Lethal Challenge

(2015) Valentina Franceschi et al.   PLoS Neglected Tropical Diseases

Bovine herpesvirus 4-based vector delivering a hybrid rat/human HER-2 oncoantigen efficiently protects mice from autochthonous Her-2+ mammary cancer

(2015) Sarah Jacca et al.   OncoImmunology

Multiple Roles of Perforin in Hampering ERBB-2 (Her-2/neu) Carcinogenesis in Transgenic Male Mice

(2014) M. Macagno et al.   JOURNAL OF IMMUNOLOGY

Microenvironment, Oncoantigens, and Antitumor Vaccination: Lessons Learned from BALB-neuT Mice

(2014) Laura Conti et al.   Biomed Research International

Bovine neonatal pancytopenia - Comparative proteomic characterization of two BVD vaccines and the producer cell surface proteome (MDBK)

(2013) Kerstin N Euler et al.   BMC Veterinary Research

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Preclinical vaccines against mammary carcinoma

(2013) Pier-Luigi Lollini et al.   Expert Review of Vaccines

The noninflammatory role of high mobility group box 1/toll-like receptor 2 axis in the self-renewal of mammary cancer stem cells

(2013) Laura Conti et al.   FASEB JOURNAL

Redox regulation in stem-like cancer cells by CD44 variant isoforms

(2013) O Nagano et al.   ONCOGENE

Clinical Protection of Goats against CpHV-1 Induced Genital Disease with a BoHV-4-Based Vector Expressing CpHV-1 gD

(2013) Gaetano Donofrio et al.   PLoS One

Efficient heterologous antigen gene delivery and expression by a replication-attenuated BoHV-4-based vaccine vector

(2013) Antonio Capocefalo et al.   VACCINE

The evolving concept of cancer and metastasis stem cells

(2012) Irène Baccelli et al.   JOURNAL OF CELL BIOLOGY

Th17 Cells in Multiple Sclerosis Express Higher Levels of JAK2, Which Increases Their Surface Expression of IFN- R2

(2012) L. Conti et al.   JOURNAL OF IMMUNOLOGY

Herpes simplex virus type 1 thymidine kinase–armed bovine herpesvirus type 4–based vector displays enhanced oncolytic properties in immunocompetent orthotopic syngenic mouse and rat glioma models

(2012) Marco Redaelli et al.   NEURO-ONCOLOGY

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

Immunization of knock-out α/β interferon receptor mice against lethal bluetongue infection with a BoHV-4-based vector expressing BTV-8 VP2 antigen

(2011) Valentina Franceschi et al.   VACCINE

Expression and secretion of Bluetongue virus serotype 8 (BTV-8)VP2 outer capsid protein by mammalian cells

(2010) A. Capocefalo et al.   JOURNAL OF VIROLOGICAL METHODS

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β

(2009) Luca Durelli et al.   ANNALS OF NEUROLOGY

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

Cellular Targeting of Engineered Heterologous Antigens Is a Determinant Factor for Bovine Herpesvirus 4-Based Vaccine Vector Development

(2009) G. Donofrio et al.   Clinical and Vaccine Immunology

Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer

(2009) E. Charafe-Jauffret et al.   CLINICAL CANCER RESEARCH

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway

(2008) R-S Chen et al.   ONCOGENE

Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2/BoHV-1-gD

(2008) G. Donofrio et al.   VACCINE