A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo

Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells

(2017) Yeonhwa Song et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

SLC7A11 Overexpression in Glioblastoma Is Associated with Increased Cancer Stem Cell-Like Properties

(2017) Monika D. Polewski et al.   STEM CELLS AND DEVELOPMENT

Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma

(2017) Makoto Nishino et al.   Journal of Cancer

NK cells control breast cancer and related cancer stem cell hematological spread

(2017) Rossana Tallerico et al.   OncoImmunology

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

(2016) Kimberly J. Briggs et al.   CELL

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells

(2016) Masanori Hasegawa et al.   Oncotarget

Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

(2016) Tina Sehm et al.   Oncotarget

L-Ferritin targets breast cancer stem cells and delivers therapeutic and imaging agents

(2016) Laura Conti et al.   Oncotarget

Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic Implications

(2016) Huai-Qiang Ju et al.   Theranostics

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

(2015) Ming-zhe Ma et al.   CANCER LETTERS

 -Catenin Promotes Regulatory T-cell Responses in Tumors by Inducing Vitamin A Metabolism in Dendritic Cells

(2015) Y. Hong et al.   CANCER RESEARCH

Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer

(2015) S. Lanzardo et al.   CANCER RESEARCH

Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs

(2015) Y. D. Bhutia et al.   CANCER RESEARCH

Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian mice

(2015) Ikuko Miyazaki et al.   JOURNAL OF NEUROCHEMISTRY

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

(2015) Haiquan Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cholesterol-lowering VLP vaccine that targets PCSK9

(2015) Erin Crossey et al.   VACCINE

Preclinical refinements of a broadly protective VLP-based HPV vaccine targeting the minor capsid protein, L2

(2015) Ebenezer Tumban et al.   VACCINE

Affinity selection of epitope-based vaccines using a bacteriophage virus-like particle platform

(2015) John P O’Rourke et al.   Current Opinion in Virology

In Vivo Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors

(2015) Nabendu Pore et al.   NEOPLASIA

Epitope-Specific Anti-hCG Vaccines on a Virus Like Particle Platform

(2015) Jerri Caldeira et al.   PLoS One

RETRACTED ARTICLE: Suppression of the xCT–CD44v antiporter system sensitizes triple-negative breast cancer cells to doxorubicin

(2014) Feng Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

CSPG4-Specific Immunity and Survival Prolongation in Dogs with Oral Malignant Melanoma Immunized with Human CSPG4 DNA

(2014) F. Riccardo et al.   CLINICAL CANCER RESEARCH

Mammary stem cells and the differentiation hierarchy: current status and perspectives

(2014) J. E. Visvader et al.   GENES & DEVELOPMENT

Multiple Roles of Perforin in Hampering ERBB-2 (Her-2/neu) Carcinogenesis in Transgenic Male Mice

(2014) M. Macagno et al.   JOURNAL OF IMMUNOLOGY

Development of a Mimotope Vaccine Targeting the Staphylococcus aureus Quorum Sensing Pathway

(2014) John P. O’Rourke et al.   PLoS One

Microenvironment, Oncoantigens, and Antitumor Vaccination: Lessons Learned from BALB-neuT Mice

(2014) Laura Conti et al.   Biomed Research International

Preclinical efficacy and safety of an anti-IL-1β vaccine for the treatment of type 2 diabetes

(2014) Gunther Spohn et al.   Molecular Therapy-Methods & Clinical Development

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma

(2013) M. Yoshikawa et al.   CANCER RESEARCH

The noninflammatory role of high mobility group box 1/toll-like receptor 2 axis in the self-renewal of mammary cancer stem cells

(2013) Laura Conti et al.   FASEB JOURNAL

Human NK Cells Selective Targeting of Colon Cancer-Initiating Cells: A Role for Natural Cytotoxicity Receptors and MHC Class I Molecules

(2013) R. Tallerico et al.   JOURNAL OF IMMUNOLOGY

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

Redox regulation in stem-like cancer cells by CD44 variant isoforms

(2013) O Nagano et al.   ONCOGENE

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1

(2013) E. G. Geier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma

(2011) Weijie Guo et al.   CANCER LETTERS

Peptide Epitope Identification by Affinity Selection on Bacteriophage MS2 Virus-Like Particles

(2011) Bryce Chackerian et al.   JOURNAL OF MOLECULAR BIOLOGY

Attenuation of PI3K/Akt-Mediated Tumorigenic Signals through PTEN Activation by DNA Vaccine-Induced Anti-ErbB2 Antibodies

(2010) A. Porzia et al.   JOURNAL OF IMMUNOLOGY

Preparation and Analysis of the Central Nervous System

(2010) William H. Jordan et al.   TOXICOLOGIC PATHOLOGY

Immunogenic display of diverse peptides, including a broadly cross-type neutralizing human papillomavirus L2 epitope, on virus-like particles of the RNA bacteriophage PP7

(2010) Jerri do Carmo Caldeira et al.   VACCINE

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults

(2009) Pierre A Robe et al.   BMC CANCER

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

IL-6, but not IFN-γ, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing

(2009) G Regis et al.   LEUKEMIA

The x c − cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine

(2008) Jun Guan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Murine pneumotropic virus chimeric Her2/neuvirus-like particles as prophylactic and therapeutic vaccines against Her2/neuexpressing tumors

(2008) Kalle Andreasson et al.   INTERNATIONAL JOURNAL OF CANCER

Immunogenic Display of Diverse Peptides on Virus-like Particles of RNA Phage MS2

(2008) David S. Peabody et al.   JOURNAL OF MOLECULAR BIOLOGY

Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study

(2008) Alain C Tissot et al.   LANCET

Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway

(2008) R-S Chen et al.   ONCOGENE