MDR1 in immunity: friend or foe?

Autocrine Adenosine regulates tumor polyfunctional CD73+CD4+ effector T cells devoid of immune checkpoints

(2018) Nicolas Gourdin et al.   CANCER RESEARCH

The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids

(2017) Wei Cao et al.   IMMUNITY

Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions

(2017) Martha L. Pinzón-Daza et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma

(2017) A Besse et al.   LEUKEMIA

Polymorphisms in the multidrug-resistance 1 gene related to glucocorticoid response in rheumatoid arthritis treatment

(2017) Bart V. J. Cuppen et al.   RHEUMATOLOGY INTERNATIONAL

A subset of virus-specific CD161+T cells selectively express the multidrug transporter MDR1 and are resistant to chemotherapy in AML

(2016) Abdullah Alsuliman et al.   BLOOD

Alterations in P-Glycoprotein Expression and Function Between Macrophage Subsets

(2016) Theodore J. Cory et al.   PHARMACEUTICAL RESEARCH

Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance

(2016) Kenji Murata et al.   OncoImmunology

Circulating and tumor-infiltrating mucosal associated invariant T (MAIT) cells in colorectal cancer patients

(2016) Limian Ling et al.   Scientific Reports

Development of Fourth Generation ABC Inhibitors from Natural Products: A Novel Approach to Overcome Cancer Multidrug Resistance

(2015) Subburayan Karthikeyan et al.   Anti-Cancer Agents in Medicinal Chemistry

Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics

(2015) N A Seebacher et al.   BRITISH JOURNAL OF PHARMACOLOGY

CD161intCD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut

(2015) J R Fergusson et al.   Mucosal Immunology

Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice

(2015) Jiali Liu et al.   Scientific Reports

Immune cell dysfunctions in breast cancer patients detected through whole blood multi-parametric flow cytometry assay

(2015) E. Verronèse et al.   OncoImmunology

Human bone marrow contains a subset of quiescent early memory CD8+T cells characterized by high CD127 expression and efflux capacity

(2014) Robert F. Kudernatsch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human regulatory T cells lack the cyclophosphamide-extruding transporter ABCB1 and are more susceptible to cyclophosphamide-induced apoptosis

(2014) Sarah Dimeloe et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MDR1polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients

(2013) Marko Brinar et al.   BMC GASTROENTEROLOGY

Targeting the Y/CCAAT box in cancer: YB-1 (YBX1) or NF-Y?

(2013) D Dolfini et al.   CELL DEATH AND DIFFERENTIATION

Influence of MDR1 C1236T polymorphism on lopinavir plasma concentration and virological response in HIV-1-infected children

(2013) Carolina P. Bellusci et al.   GENE

Expression ofmultidrug resistance 1gene in B-cell lymphomas: association with follicular dendritic cells

(2013) Keiko Yagi et al.   HISTOPATHOLOGY

Expression levels of P-glycoprotein in peripheral blood CD8+ T lymphocytes from HIV-1-infected patients on antiretroviral therapy

(2013) JIU-CONG ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Genetic Polymorphisms in ABCB1 Influence the Pharmacodynamics of Tacrolimus

(2013) Ramin Vafadari et al.   THERAPEUTIC DRUG MONITORING

miR-137 restoration sensitizes multidrug-resistant MCF-7/ADM cells to anticancer agents by targeting YB-1

(2012) X. Zhu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Altered generation of induced regulatory T cells in the FVB.mdr1a−/− mouse model of colitis

(2012) S M Tanner et al.   Mucosal Immunology

Immunological effects of Taxol and Adryamicin in breast cancer patients

(2011) C. Panis et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Discovering Natural Product Modulators to Overcome Multidrug Resistance in Cancer Chemotherapy

(2011) Chung-Pu Wu et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma

(2011) Huiling Shen et al.   EXPERIMENTAL HEMATOLOGY

Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases

(2011) Zhe-Sheng Chen et al.   FEBS Journal

CD161-Expressing Human T Cells

(2011) Joannah R. Fergusson et al.   Frontiers in Immunology

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Prediction of response to disease modifying antirheumatic drugs in rheumatoid arthritis

(2010) Jean-Francis Maillefert et al.   JOINT BONE SPINE

Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia

(2010) Dan-Dan Feng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Very important pharmacogene summary

(2010) Laura M. Hodges et al.   Pharmacogenetics and Genomics

Enhanced MDR1 Expression and Chemoresistance of Cancer Stem Cells Derived from Glioblastoma

(2009) Eiichi Nakai et al.   CANCER INVESTIGATION

Expression of multidrug resistance-1 protein correlates with disease activity rather than the refractoriness to methotrexate therapy in rheumatoid arthritis

(2009) V. Agarwal et al.   CLINICAL RHEUMATOLOGY

A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy

(2009) Cameron J. Turtle et al.   IMMUNITY

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML)

(2008) Ruoping Tang et al.   BMC CANCER

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Substrate-Dependent Effects of Human ABCB1 Coding Polymorphisms

(2008) J. M. Gow et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS