The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings

Acetaminophen and Asthma: Spurious Association?

(2013) Kwok Chiu Chang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Can Intravenous Paracetamol Reduce Opioid Use in Preoperative Hip Fracture Patients?

(2013) Kai S. Tsang et al.   ORTHOPEDICS

Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses

(2013) K. Hawton et al.   BMJ-British Medical Journal

Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension

(2012) Hisham Aljadhey et al.   BMC Cardiovascular Disorders

Use of Nonsteroidal Anti-inflammatory Drugs and Risk of Ovarian and Endometrial Cancer: The Multiethnic Cohort

(2012) V. W. Setiawan et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Nonsteroidal Antiinflammatory Drugs, Acetaminophen, and Hypertension

(2012) Isabella Sudano et al.   CURRENT HYPERTENSION REPORTS

Early antipyretic exposure does not increase mortality in patients with gram-negative severe sepsis: a retrospective cohort study

(2012) Nicholas Mohr et al.   Internal and Emergency Medicine

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

(2012) Marc C. Hochberg et al.   ARTHRITIS CARE & RESEARCH

Effects of high-dose paracetamol on blood pressure in acute stroke

(2011) H. M. den Hertog et al.   ACTA NEUROLOGICA SCANDINAVICA

Paracetamol and cyclooxygenase inhibition: is there a cause for concern?

(2011) Burkhard Hinz et al.   ANNALS OF THE RHEUMATIC DISEASES

A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain

(2011) M. Doherty et al.   ANNALS OF THE RHEUMATIC DISEASES

Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review

(2011) E Maund et al.   BRITISH JOURNAL OF ANAESTHESIA

A Large Cohort Study of Long-term Acetaminophen Use and Prostate Cancer Incidence

(2011) E. J. Jacobs et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases--Safety, Pharmacokinetics, and Pharmacodynamics

(2011) L. M. Howells et al.   Cancer Prevention Research

The Effects of Nonsteroidal Anti-Inflammatory Drugs on Blood Pressure in Hypertensive Patients

(2011) Stanley Snowden et al.   Cardiology in Review

Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis

(2011) S. Eyers et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Opioid-Paracetamol Prescription Patterns and Liver Dysfunction

(2011) Jane R. Mort et al.   DRUG SAFETY

High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase

(2011) Philip E. Morgan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tropisetron and paracetamol association in post-operative patients

(2011) Gisèle Pickering et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Influence of acetaminophen and ibuprofen on in vivo patellar tendon adaptations to knee extensor resistance exercise in older adults

(2011) C. C. Carroll et al.   JOURNAL OF APPLIED PHYSIOLOGY

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

(2011) Kelsey C Duggan et al.   Nature Chemical Biology

Tropisetron blocks analgesic action of acetaminophen: A human pain model study

(2011) Oliver Bandschapp et al.   PAIN

A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen/paracetamol for postoperative dental pain

(2011) Stephen E. Daniels et al.   PAIN

Osteopontin Expression during Early Cerebral Ischemia-Reperfusion in Rats: Enhanced Expression in the Right Cortex Is Suppressed by Acetaminophen

(2011) Sunanda S. Baliga et al.   PLoS One

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study

(2010) R. C. Dart et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults

(2010) Todd A. Trappe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Acetaminophen Use and Risk of Asthma, Rhinoconjunctivitis, and Eczema in Adolescents

(2010) Richard W. Beasley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Comparative Safety of Analgesics in Older Adults With Arthritis

(2010) Daniel H. Solomon   ARCHIVES OF INTERNAL MEDICINE

The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

(2010) Amanda E. Lane et al.   BIOCHEMICAL JOURNAL

Acetaminophen reduces mitochondrial dysfunction during early cerebral postischemic reperfusion in rats

(2010) Sunanda S. Baliga et al.   BRAIN RESEARCH

Overdose pattern and outcome in paracetamol-induced acute severe hepatotoxicity

(2010) Darren G. N. Craig et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Acetaminophen Increases Blood Pressure in Patients With Coronary Artery Disease

(2010) Isabella Sudano et al.   CIRCULATION

The Influence of Ondansetron on the Analgesic Effect of Acetaminophen After Laparoscopic Hysterectomy

(2010) R Jokela et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Use of Pharmaco-Metabonomics for Early Prediction of Acetaminophen-Induced Hepatotoxicity in Humans

(2010) J H Winnike et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Fish oil supplementation increases the cyclooxygenase inhibitory activity of paracetamol in rheumatoid arthritis patients

(2010) Gillian E. Caughey et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Study designs in paediatric pharmacoepidemiology

(2010) Katia Verhamme et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Paracetamol for intravenous use in medium- and intensive care patients: pharmacokinetics and tolerance

(2010) Monique M. de Maat et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents

(2010) Romina Nassini et al.   FASEB JOURNAL

Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure

(2010) Olivier Boutaud et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of the diclofenac-induced cyclooxygenase-2 activity by paracetamol in cultured macrophages is not related to the intracellular lipid hydroperoxide tone

(2010) Samir S. Ayoub et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole

(2010) H G Shertzer et al.   INTERNATIONAL JOURNAL OF OBESITY

A Bifunctional Role for Group IIA Secreted Phospholipase A2in Human Rheumatoid Fibroblast-like Synoviocyte Arachidonic Acid Metabolism

(2010) Katherine J. Bryant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

(2010) Michael J. Davies   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty

(2010) S. J. Mitchell et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

A Risk-Benefit Assessment of Paracetamol (Acetaminophen) Combined with Caffeine

(2010) Hazel Palmer et al.   PAIN MEDICINE

Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure

(2010) O. Boutaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link

(2010) H. Conroy et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

A Literature Review of Randomized Clinical Trials of Intravenous Acetaminophen (Paracetamol) for Acute Postoperative Pain

(2010) Alex Macario et al.   Pain Practice

FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?

(2010) Garry G. Graham et al.   INFLAMMOPHARMACOLOGY

Mechanisms of Non-Opioid Analgesics Beyond Cyclooxygenase Enzyme Inhibition

(2010) May Hamza et al.   Current Molecular Pharmacology

The Effects of Intrathecal Cyclooxygenase-1, Cyclooxygenase-2, or Nonselective Inhibitors on Pain Behavior and Spinal Fos-Like Immunoreactivity

(2009) Il Ok Lee et al.   ANESTHESIA AND ANALGESIA

Interventional Pain Treatments for Cancer Pain

(2009) Paul J. Christo et al.   Annals of the New York Academy of Sciences

Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease

(2009) Betty S. van der Veen et al.   ANTIOXIDANTS & REDOX SIGNALING

Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione

(2009) Valdecir F. Ximenes et al.   BIOCHEMICAL JOURNAL

Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations

(2009) Maud Koelsch et al.   BIOCHEMICAL PHARMACOLOGY

Acetaminophen Use and the Risk of Asthma in Children and Adults

(2009) Mahyar Etminan et al.   CHEST

Evaluation of analgesic efficacy, gastrotoxicity and nephrotoxicity of fixed-dose combinations of nonselective, preferential and selective cyclooxgenase inhibitors with paracetamol in rats

(2009) Gaurav Kumar et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Use of acetaminophen during pregnancy and risk of preeclampsia, hypertensive and vascular disorders: A birth cohort study

(2009) Cristina Rebordosa et al.   Journal of Maternal-Fetal & Neonatal Medicine

Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress

(2009) Debjani Tripathy et al.   Journal of Neuroinflammation

Resveratrol inhibits prostaglandin formation in IL-1β-stimulated SK-N-SH neuronal cells

(2009) Lena Wendeburg et al.   Journal of Neuroinflammation

Acetaminophen, aspirin and progression of advanced chronic kidney disease

(2009) M. Evans et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors

(2009) Sudhir N. Umathe et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Effect of intravenous administration of paracetamol on morphine consumption in cancer pain control

(2009) Buket Tasmacioglu et al.   SUPPORTIVE CARE IN CANCER

Analgesic effect of paracetamol on cancer related pain in concurrent strong opioid therapy. A prospective clinical study

(2008) Bertil Axelsson et al.   ACTA ONCOLOGICA

The Antiplatelet Effect of Six Non-Steroidal Anti-Inflammatory Drugs and Their Pharmacodynamic Interaction With Aspirin in Healthy Volunteers

(2008) Patrick A. Gladding et al.   AMERICAN JOURNAL OF CARDIOLOGY

Hospitalizations for Upper and Lower GI Events Associated With Traditional NSAIDs and Acetaminophen Among the Elderly in Quebec, Canada

(2008) Elham Rahme et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Mammalian Heme Peroxidases: From Molecular Mechanisms to Health Implications

(2008) Michael J. Davies et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective effect of resveratrol in endotoxemia-induced acute phase response in rats

(2008) Hichem Sebai et al.   ARCHIVES OF TOXICOLOGY

Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid

(2008) Mitchell M. Lloyd et al.   BIOCHEMICAL JOURNAL

Hypobromous acid and bromamine production by neutrophils and modulation by superoxide

(2008) Anna L. P. Chapman et al.   BIOCHEMICAL JOURNAL

Acetaminophen normalizes glucose homeostasis in mouse models for diabetes

(2008) Howard G. Shertzer et al.   BIOCHEMICAL PHARMACOLOGY

Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet

(2008) Eric L. Kendig et al.   BIOCHEMICAL PHARMACOLOGY

Structural and Kinetic Analyses of Macrophage Migration Inhibitory Factor Active Site Interactions†‡

(2008) Gregg V. Crichlow et al.   BIOCHEMISTRY

Preventive Effects of Nutritional Doses of Polyphenolic Molecules on Cardiac Fibrosis Associated with Metabolic Syndrome: Involvement of Osteopontin and Oxidative Stress

(2008) Thibault Sutra et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The role of non-steroidal anti-inflammatory drugs in the risk of development and treatment of hematologic malignancies

(2008) Pawel Robak et al.   LEUKEMIA & LYMPHOMA

Differential involvement of opioidergic and serotonergic systems in the antinociceptive activity of N-arachidonoyl-phenolamine (AM404) in the rat: comparison with paracetamol

(2008) Valentina Ruggieri et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Acetaminophen prevents hyperalgesia in central pain cascade

(2008) Brianna Crawley et al.   NEUROSCIENCE LETTERS

Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia

(2008) Christophe Mallet et al.   PAIN

The pharmacology and therapeutic relevance of endocannabinoid derived cyclo-oxygenase (COX)-2 products

(2008) D.F. Woodward et al.   PHARMACOLOGY & THERAPEUTICS

The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models

(2008) Y SEO et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effect of Intravenous Propacetamol on Blood Pressure in Febrile Critically Ill Patients

(2008) Moshe Hersch et al.   PHARMACOTHERAPY

COX-2 Selective Inhibitors in the Treatment of Osteoarthritis

(2008) Loren Laine et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS-activator peroxynitrite

(2007) Stefan Schildknecht et al.   FASEB JOURNAL

Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man

(2007) Burkhard Hinz et al.   FASEB JOURNAL

Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain

(2007) H MIRANDA et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Acetaminophen: Antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant

(2007) Shuxin Li et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS