Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption

Long-term treatment strategies for postmenopausal osteoporosis

(2018) Felicia Cosman   CURRENT OPINION IN RHEUMATOLOGY

Denosumab

(2018) Andrew Wilcock et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

An expanded immunohistochemical profile of osteoclast-rich undifferentiated carcinoma of the urinary tract

(2018) Salvatore F. Priore et al.   MODERN PATHOLOGY

Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss

(2018) Brigitte Raynaud-Messina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors

(2017) Zhenqiang Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMI-1 Mediates Estrogen-Deficiency-Induced Bone Loss by Inhibiting Reactive Oxygen Species Accumulation and T Cell Activation

(2017) Jinbo Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hydroxychloroquine affects bone resorption both in vitro and in vivo

(2017) Tim Both et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes

(2017) Ryan D. Molony et al.   Science Signaling

Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes

(2017) Ryan D. Molony et al.   Science Signaling

Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo

(2016) Vidal Jarauta et al.   CANCER LETTERS

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

(2016) Jian Luo et al.   NATURE MEDICINE

Invasive ductal carcinoma of the breast with osteoclast-like giant cells and clear cell features: a case report of a novel finding and review of the literature

(2016) Nicole K. Zagelbaum et al.   World Journal of Surgical Oncology

Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis

(2016) Nida Meednu et al.   Arthritis & Rheumatology

RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis

(2016) William O'Brien et al.   Arthritis & Rheumatology

RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation

(2015) Lynett Danks et al.   ANNALS OF THE RHEUMATIC DISEASES

The RANKL-RANK Story

(2015) Vanja Nagy et al.   GERONTOLOGY

Ca2+-Dependent Regulations and Signaling in Skeletal Muscle: From Electro-Mechanical Coupling to Adaptation

(2015) Sebastian Gehlert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

(2015) Megan M Weivoda et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Macrophages: Their Emerging Roles in Bone

(2015) Benjamin P Sinder et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

(2015) David L Waning et al.   NATURE MEDICINE

RANKL/OPG; Critical role in bone physiology

(2015) T. John Martin et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Osteopetrosis and Its Relevance for the Discovery of New Functions Associated with the Skeleton

(2015) Amélie E. Coudert et al.   International Journal of Endocrinology

Chondrocytes-Specific Expression of Osteoprotegerin Modulates Osteoclast Formation in Metaphyseal Bone

(2015) Baoli Wang et al.   Scientific Reports

Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases

(2015) Dulshara Sachini Amarasekara et al.   Journal of Immunology Research

Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

(2015) Natalie A. Sims et al.   Frontiers in Endocrinology

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

(2015) Jinhu Xiong et al.   PLoS One

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling

(2014) Janet L. Crane et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid Cell TRAF3 Regulates Immune Responses and Inhibits Inflammation and Tumor Development in Mice

(2014) Almin I. Lalani et al.   JOURNAL OF IMMUNOLOGY

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

(2014) Sofia Movérare-Skrtic et al.   NATURE MEDICINE

Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB

(2014) Bo Yu et al.   NATURE MEDICINE

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

Mice Deficient in NF-κB p50 and p52 or RANK Have Defective Growth Plate Formation and Post-natal Dwarfism

(2014) Lianping Xing et al.   Bone Research

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists

(2013) Moriteru Asano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Osteocyte: An Endocrine Cell … and More

(2013) Sarah L. Dallas et al.   ENDOCRINE REVIEWS

CXCL12/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations

(2013) Mohammad Shahnazari et al.   FASEB JOURNAL

Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts

(2013) Brendan F Boyce   JOURNAL OF BONE AND MINERAL RESEARCH

Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

(2013) Yan Xiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteopetrosis: genetics, treatment and new insights into osteoclast function

(2013) Cristina Sobacchi et al.   Nature Reviews Endocrinology

The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis)

(2012) L. van der Heijden et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Osteocyte RANKL: New insights into the control of bone remodeling

(2012) Jinhu Xiong et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment

(2012) Atsushi Arai et al.   JOURNAL OF CELL SCIENCE

Bone Loss in the HIV-Infected Patient: Evidence, Clinical Implications, and Treatment Strategies

(2012) Vanessa Walker Harris et al.   JOURNAL OF INFECTIOUS DISEASES

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

Disorders of Bone Remodeling

(2011) Xu Feng et al.   Annual Review of Pathology-Mechanisms of Disease

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

(2011) Alexander David Barrow et al.   JOURNAL OF CLINICAL INVESTIGATION

Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by  -Catenin

(2011) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

The Critical Role of IL-34 in Osteoclastogenesis

(2011) Zhi Chen et al.   PLoS One

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

(2011) Baohong Zhao et al.   ARTHRITIS RESEARCH & THERAPY

Biomarkers of the Osteoprotegerin Pathway

(2010) Wolfgang Lieb et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Molecular pathways involved in synovial cell inflammation and tumoral proliferation in diffuse pigmented villonodular synovitis

(2010) U. Fiocco et al.   AUTOIMMUNITY REVIEWS

TRAF3 Controls Activation of the Canonical and Alternative NFκB by the Lymphotoxin Beta Receptor

(2010) Pradeep Bista et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Mitf Induction by RANKL Is Critical for Osteoclastogenesis

(2010) Ssu-Yi Lu et al.   MOLECULAR BIOLOGY OF THE CELL

New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis

(2010) J. C. Crockett et al.   OSTEOPOROSIS INTERNATIONAL

NIK Stabilization in Osteoclasts Results in Osteoporosis and Enhanced Inflammatory Osteolysis

(2010) Chang Yang et al.   PLoS One

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

(2009) Zhenqiang Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

(2009) Masaru Ishii et al.   NATURE

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Functions of RANKL/RANK/OPG in bone modeling and remodeling

(2008) Brendan F. Boyce et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Osteoclast lineage and function

(2008) H. Kalervo Väänänen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

TRAF6 negatively regulates TNFα-induced NF-κB activation

(2008) Megumi Funakoshi-Tago et al.   CYTOKINE

Lipopolysaccharide suppresses RANK gene expression in macrophages by down-regulating PU.1 and MITF

(2008) Junko Ishii et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Control of canonical NF- B activation through the NIK-IKK complex pathway

(2008) B. Zarnegar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

(2008) L. Pederson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ocular Toxicity of Hydroxychloroquine

(2008) Rodney Tehrani et al.   Seminars in Ophthalmology