Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts

Inhibitory Immunoglobulin-Like Receptors LILRB and PIR-B Negatively Regulate Osteoclast Development

(2014) Y. Mori et al.   JOURNAL OF IMMUNOLOGY

Bisphosphonate Therapy for Osteoporosis: Benefits, Risks, and Drug Holiday

(2012) Michael McClung et al.   AMERICAN JOURNAL OF MEDICINE

Bone Modeling and Remodeling

(2012) Ego Seeman   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Osteoclasts Have Multiple Roles in Bone in Addition to Bone Resorption

(2012) Brendan Boyce et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

The osteoclast, bone remodelling and treatment of metabolic bone disease

(2012) Brendan F. Boyce et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Denosumab: mechanism of action and clinical outcomes

(2012) D. A. Hanley et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Autophagy: A new player in skeletal maintenance?

(2012) Lynne J Hocking et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of T cells in ovariectomy induced bone loss-revisited

(2012) Roberto Pacifici   JOURNAL OF BONE AND MINERAL RESEARCH

Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function

(2012) Julia F. Charles et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and Function of Murine B Cells Lacking RANK

(2012) T. Perlot et al.   JOURNAL OF IMMUNOLOGY

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

Potential first-in-class osteoporosis drug speeds through trials

(2012) Sarah C P Williams   NATURE MEDICINE

Vitamin E decreases bone mass by stimulating osteoclast fusion

(2012) Koji Fujita et al.   NATURE MEDICINE

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

New developments in osteoimmunology

(2012) Hiroshi Takayanagi   Nature Reviews Rheumatology

New insights into osteoclastogenic signaling mechanisms

(2012) Tomoki Nakashima et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Interleukin-17A upregulates receptor activator of NF-κB on osteoclast precursors

(2012) Iannis E Adamopoulos et al.   ARTHRITIS RESEARCH & THERAPY

The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints

(2012) Tania N Crotti et al.   ARTHRITIS RESEARCH & THERAPY

Bone cell interactions through Eph/ephrin

(2012) Koichi Matsuo et al.   Cell Adhesion & Migration

Inhibition of Cathepsin K for Treatment of Osteoporosis

(2012) Steven Boonen et al.   Current Osteoporosis Reports

How are osteoclasts induced to resorb bone?

(2011) T.J. Chambers et al.   Annals of the New York Academy of Sciences

The osteoclast and its unique cytoskeleton

(2011) Steven L. Teitelbaum   Annals of the New York Academy of Sciences

Distinguishing the proapoptotic and antiresorptive functions of risedronate in murine osteoclasts: Role of the Akt pathway and the ERK/Bim axis

(2011) Takumi Matsumoto et al.   ARTHRITIS AND RHEUMATISM

Bisphosphonates: The first 40years

(2011) R. Graham G. Russell   BONE

Paget's disease of bone

(2011) Tim Cundy et al.   CLINICAL BIOCHEMISTRY

Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption

(2011) Carl J. DeSelm et al.   DEVELOPMENTAL CELL

Osteoclast Activity and Subtypes as a Function of Physiology and Pathology—Implications for Future Treatments of Osteoporosis

(2011) K. Henriksen et al.   ENDOCRINE REVIEWS

Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)

(2011) Ya-Hui Chiu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lineage-committed osteoclast precursors circulate in blood and settle down into bone

(2011) Akinori Muto et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

(2011) Sarah Schmidt et al.   JOURNAL OF CELL BIOLOGY

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

(2011) Alexander David Barrow et al.   JOURNAL OF CLINICAL INVESTIGATION

The skeleton: a multi-functional complex organ. The role of key signalling pathways in osteoclast differentiation and in bone resorption

(2011) David J Mellis et al.   JOURNAL OF ENDOCRINOLOGY

Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study

(2011) Karim Fizazi et al.   LANCET

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Suppression of bone formation by osteoclastic expression of semaphorin 4D

(2011) Takako Negishi-Koga et al.   NATURE MEDICINE

TGF-β Inducible Early Gene 1 Regulates Osteoclast Differentiation and Survival by Mediating the NFATc1, AKT, and MEK/ERK Signaling Pathways

(2011) Muzaffer Cicek et al.   PLoS One

Regulation of bone by the adaptive immune system in arthritis

(2011) Kazuo Okamoto et al.   ARTHRITIS RESEARCH & THERAPY

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

(2011) Baohong Zhao et al.   ARTHRITIS RESEARCH & THERAPY

A review of the efficacy and safety of denosumab in postmenopausal women with osteoporosis

(2011) Paul D. Miller   Therapeutic Advances in Musculoskeletal Disease

Functions of nuclear factor κB in bone

(2010) Brendan F. Boyce et al.   Annals of the New York Academy of Sciences

The immune system and bone

(2010) Roberto Pacifici   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin

(2010) David J. Mahoney et al.   ARTHRITIS AND RHEUMATISM

Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells

(2010) H. Li et al.   BLOOD

Biochemical and molecular mechanisms of action of bisphosphonates

(2010) Michael J. Rogers et al.   BONE

Role of NF-κB in the skeleton

(2010) Deborah Veis Novack   CELL RESEARCH

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

(2010) David E. Hughes et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Theoretical perspective: A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates

(2010) A.M. Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

IKKβ activation is sufficient for RANK-independent osteoclast differentiation and osteolysis

(2010) Jesse E Otero et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

T cell suppression by osteoclasts in vitro

(2010) Francesco Grassi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Blimp1–Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis

(2010) Yoshiteru Miyauchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis Synovium

(2010) A. J. Hueber et al.   JOURNAL OF IMMUNOLOGY

The multiple faces of autoimmune-mediated bone loss

(2010) Georg Schett et al.   Nature Reviews Endocrinology

New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis

(2010) J. C. Crockett et al.   OSTEOPOROSIS INTERNATIONAL

Cellular mechanisms of bone remodeling

(2010) Erik Fink Eriksen   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis

(2010) Junichi Kikuta et al.   RHEUMATOLOGY INTERNATIONAL

Estrogens Maintain Bone Mass by Regulating Expression of Genes Controlling Function and Life Span in Mature Osteoclasts

(2009) Yuuki Imai et al.   Annals of the New York Academy of Sciences

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

(2009) Zhenqiang Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

(2008) Matteo M. Guerrini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Physical Mechanism for Coupling Bone Resorption and Formation in Adult Human Bone

(2008) Thomas Levin Andersen et al.   AMERICAN JOURNAL OF PATHOLOGY

Functions of RANKL/RANK/OPG in bone modeling and remodeling

(2008) Brendan F. Boyce et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Synaptotagmin VII Regulates Bone Remodeling by Modulating Osteoclast and Osteoblast Secretion

(2008) Haibo Zhao et al.   DEVELOPMENTAL CELL

Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival

(2008) Susan A Krum et al.   EMBO JOURNAL

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

(2008) Ann E. Kearns et al.   ENDOCRINE REVIEWS

Actin cytoskeletal organisation in osteoclasts: A model to decipher transmigration and matrix degradation

(2008) F SALTEL et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway

(2008) Estelle Chamoux et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood

(2008) Qian Zhang et al.   ARTHRITIS RESEARCH & THERAPY

Genetics, pathogenesis and complications of osteopetrosis

(2007) Andrea Del Fattore et al.   BONE