Article
Pathology
Swati Satturwar, Anil Parwani, Roby Thomas, Sheldon Bastacky, Rajiv Dhir, Gabriela M. Quiroga-Garza
Summary: Osteoclast-type giant cell-rich carcinomas (OGCRCs) of urinary bladder are rare and aggressive tumors with little known about their pathogenesis and clinical management. This study reviewed clinical and pathological features of 5 cases of OGCRCs, finding that most cases were associated with conventional bladder urothelial carcinoma (UC), suggesting an undifferentiated or dedifferentiated nature of this neoplasm.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Oncology
Yujiao Deng, Ya Wang, Yan Zhang, Na Yang, Xingli Ji, Bing Wu
Summary: Osteoclast-like giant cell tumor is a common bone tumor that rarely involves the liver. Previous reports have mainly focused on cases of osteoclast-like giant cell carcinoma of the liver, often coexisting with sarcomatoid or hepatocellular carcinoma. This case describes an extremely rare undifferentiated liver tumor with osteoclast-like giant cells and provides a comprehensive summary of previously published cases. The findings aim to improve preoperative diagnosis and management options for undifferentiated liver tumors with osteoclast-like giant cells.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Omar Alhalabi, Pavlos Msaouel
Summary: An in silico study revealed that urothelial carcinomas of the bladder and upper tract, as well as chromophobe renal cell carcinoma, are more likely to have alterations in the CDKN1A gene, which may result in loss of p21(waf1) function. These mutations could have significant prognostic and therapeutic implications for these malignancies.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Pieter Demetter, Raphael Marechal, Francesco Puleo, Myriam Delhaye, Sebastien Debroux, Fadi Charara, Maria Gomez Galdon, Jean-Luc Van Laethem, Laurine Verset
Summary: Undifferentiated carcinoma of the pancreas is an aggressive and rare tumor, with the variant UC-OGC having osteoclast-like giant cells showing some differences compared to plain undifferentiated carcinoma. UC-OGC often has a worse prognosis, but pure UC-OGC exhibits more indolent behavior.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jiyoung Yoon, Seung-Yeon Yoo, Young Soo Park, Kee Don Choi, Beom Su Kim, Moon-Won Yoo, In Seob Lee, Jeong Hwan Yook, Ga Hee Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: This study investigated the prevalence and risk factors of lymph node metastasis (LNM) in undifferentiated early gastric cancer (UD-EGC) cases meeting the expanded indication for endoscopic submucosal dissection (ESD). The results showed that the risk of LNM is higher than expected when using the current expanded indication for UD-EGC. Histological evaluation could provide useful clues for reducing the risk of LNM.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Thomas van Doeveren, Jose A. Nakauma-Gonzalez, Andrew S. Mason, Geert J. L. H. van Leenders, Tahlita C. M. Zuiverloon, Ellen C. Zwarthoff, Isabelle C. Meijssen, Angelique C. van der Made, Antoine G. van Der Heijden, Kees Hendricksen, Bas W. G. van Rhijn, Charlotte S. Voskuilen, Job van Riet, Winand N. M. Dinjens, Hendrikus J. Dubbink, Harmen J. G. van de Werken, Joost L. Boormans
Summary: By sequencing genes in 15 UTUC patients treated by RNU, it was found that the majority of patients had a clonal relationship between UTUC and subsequent UCB, supporting the idea that UCBs following UTUC surgery are primarily clonally derived recurrences.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Ni Zhao, Nan Mei, Ye Yi, Hongyan Wang, Yajian Wang, Yu Yao, Chunli Li
Summary: This study retrospectively analyzed the clinical data and follow-up results of four patients with pancreatic undifferentiated carcinoma with osteoclast-like giant cells. The study identified the characteristics of the disease and discussed the key points of treatment. The main symptoms of patients included upper abdominal pain and discomfort, nausea and vomiting, or no symptoms. Tumor location varied and metastasis was observed in pancreatic adipose tissue and lymph nodes.
PATHOLOGY & ONCOLOGY RESEARCH
(2023)
Article
Oncology
Mamoru Hashimoto, Kazutoshi Fujita, Eisuke Tomiyama, Saizo Fujimoto, Shogo Adomi, Eri Banno, Takafumi Minami, Tetsuya Takao, Masahiro Nozawa, Hiroaki Fushimi, Kazuhiro Yoshimura, Norio Nonomura, Hirotsugu Uemura
Summary: This study investigated the relationship between nectin-4 and HER2 and EGFR in patients with upper urinary tract urothelial carcinoma (UTUC). The results showed high expression of HER2, EGFR, and nectin-4 in UTUC patients. Combination targeted therapy for HER2, EGFR, and nectin-4 may be an effective treatment option for UTUC patients.
ANTICANCER RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Hiroshi Imaoka, Masafumi Ikeda, Kosuke Maehara, Kumiko Umemoto, Masato Ozaka, Satoshi Kobayashi, Takeshi Terashima, Hiroto Inoue, Chihiro Sakaguchi, Kunihiro Tsuji, Kazuhiko Shioji, Keiya Okamura, Akiko Tsujimoto, Ikuo Nakamura, Hirofumi Shirakawa, Masayuki Furukawa, Makoto Ueno, Chigusa Morizane, Junji Furuse
Summary: This study aimed to clarify the prognosis of patients with unresectable undifferentiated carcinoma (UC) of the pancreas and construct a prognostic model. Independent prognostic factors were identified through multivariate analysis and used to define a prognostic model that stratified patients into high-risk and low-risk groups with significant differences in overall survival.
Review
Biochemistry & Molecular Biology
Romans Uljanovs, Stanislavs Sinkarevs, Boriss Strumfs, Liga Vidusa, Kristine Merkurjeva, Ilze Strumfa
Summary: Immunohistochemistry is an indispensable tool in diagnostic surgical pathology, and it has various applications in parathyroid tumors. These applications include detecting specific protein loss, aberrant immunophenotype, histogenesis of neck masses, and pathogenetic events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Haifeng Ran, Guiqin Chen, Yulun He, Qiane Yu, Yuxin Xie, Junwei Liu, Heng Liu, Tijiang Zhang
Summary: Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas is a rare pancreatic tumor with distinct clinicopathological characteristics compared to pancreatic ductal adenocarcinoma. Imaging examinations are valuable for diagnosis and treatment planning, but further investigation is needed regarding the imaging characteristics of this tumor. This report presents a rare case of rapidly progressing undifferentiated carcinoma with osteoclast-like giant cells of the pancreas with poor prognosis. The patient received chemotherapy but did not show significant improvement, resulting in death after 6 months. The report aims to increase awareness and improve early diagnosis and therapeutic outcomes through summarizing available imaging findings.
Article
Biochemistry & Molecular Biology
Jia-Fong Jhang, Han-Chen Ho, Yuan-Hsiang Hsu, Yuan-Hong Jiang, Hann-Chorng Kuo
Summary: This study found that patients with recurrent urinary tract infection (rUTI) have bladder defects and elevated urine inflammatory markers. After treatment with platelet-rich plasma (PRP) injections, some patients showed improvement in bladder defects.
Article
Biochemistry & Molecular Biology
Alessandra Cinque, Anna Capasso, Riccardo Vago, Matteo Floris, Michael W. Lee, Roberto Minnei, Francesco Trevisani
Summary: Upper urinary tract urothelial carcinoma (UTUC) is a rare but aggressive malignancy occurring in the renal pelvis or ureter. UTUC is often diagnosed at an advanced stage due to non-specific symptoms and the lack of early biomarkers. However, microRNAs (miRNAs) show promise as novel biomarkers for optimizing the diagnosis and prognosis of UTUC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Hiroshi Imaoka, Masafumi Ikeda, Kumiko Umemoto, Yu Sunakawa, Makoto Ueno, Hideki Ueno, Masato Ozaka, Takamichi Kuwahara, Naohiro Okano, Masashi Kanai, Terumasa Hisano, Yuko Suzuki, Akinori Asagi, Kazuhiko Shioji, Akiko Todaka, Kunihiro Tsuji, Kenji Ikezawa, Ikuya Miki, Yoshito Komatsu, Noriyuki Akutsu, Tatsuya Yamashita, Hiroyuki Okuyama, Junji Furuse, Hiroaki Nagano
Summary: Undifferentiated carcinoma (UC) is an aggressive epithelial neoplasm with a poor prognosis, but recent advances in diagnostic modalities and genomic sequencing technologies are providing new possibilities for diagnosis and expanded treatments. UC of the pancreas is a rare subtype of pancreatic cancer with no definitive direction of differentiation. The World Health Organization (WHO) classifies UC into subtypes, and surgical resection is currently the only curative treatment, though there are promising results from paclitaxel-containing regimens for unresectable UC.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Lukasz Bialek, Konrad Bilski, Jakub Dobruch, Wojciech Krajewski, Tomasz Szydelko, Piotr Kryst, Slawomir Poletajew
Summary: This study aimed to evaluate the effectiveness of non-invasive tests in the diagnosis of upper urinary tract urothelial carcinoma (UTUC). Among the 10,084 screened publications, 25 were included in the analysis. Most of the studies had small sample sizes and heterogeneous control groups. Voided urinary cytology was the most commonly used test, with low sensitivity and good specificity. Fluorescence in situ hybridization in diagnostic cytology showed higher sensitivity and similarly good specificity. Other urine or blood tests had limited research and varied results. Currently, there is a lack of high-quality data confirming the effectiveness of non-invasive tests in the diagnosis of UTUC.
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.
