Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry

Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry

(2018) Laura Riva et al.   JOURNAL OF VIROLOGY

Role of the E2 Hypervariable Region (HVR1) in the Immunogenicity of a Recombinant Hepatitis C Virus Vaccine

(2018) John L. M. Law et al.   JOURNAL OF VIROLOGY

Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies

(2018) Ralf Bartenschlager et al.   VIRUS RESEARCH

Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma

(2018) Vandana Sekhar et al.   PLoS Pathogens

Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine

(2018) Mei-Le Keck et al.   Frontiers in Immunology

Glycan Shielding and Modulation of Hepatitis C Virus Neutralizing Antibodies

(2018) Muriel Lavie et al.   Frontiers in Immunology

Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design

(2018) Florian Wrensch et al.   Frontiers in Immunology

Current status and future development of infectious cell-culture models for the major genotypes of hepatitis C virus: Essential tools in testing of antivirals and emerging vaccine strategies

(2018) Santseharay Ramirez et al.   ANTIVIRAL RESEARCH

Hepatitis C virus escape studies for human monoclonal antibody AR4A reveal isolate-specific resistance and a high barrier to resistance

(2018) Rodrigo Velázquez-Moctezuma et al.   JOURNAL OF INFECTIOUS DISEASES

Defining Breadth of Hepatitis C Virus Neutralization

(2018) Valerie J. Kinchen et al.   Frontiers in Immunology

The core domain of hepatitis C virus glycoprotein E2 generates potent cross-neutralizing antibodies in guinea pigs

(2017) Patricia T. Vietheer et al.   HEPATOLOGY

The Chimpanzee Model of Viral Hepatitis: Advances in Understanding the Immune Response and Treatment of Viral Hepatitis

(2017) Robert E Lanford et al.   ILAR JOURNAL

ICTV Virus Taxonomy Profile: Flaviviridae

(2017) Peter Simmonds et al.   JOURNAL OF GENERAL VIROLOGY

Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity

(2017) Dorothea Bankwitz et al.   JOURNAL OF HEPATOLOGY

Attachment and Postattachment Receptors Important for Hepatitis C Virus Infection and Cell-to-Cell Transmission

(2017) Huahao Fan et al.   JOURNAL OF VIROLOGY

Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A

(2017) Rodrigo Velázquez-Moctezuma et al.   PLoS Pathogens

Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1

(2017) Ramy El-Diwany et al.   PLoS Pathogens

Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies

(2016) Catherine Fauvelle et al.   GASTROENTEROLOGY

Hepatitis C virus plays hide and seek with neutralizing antibodies

(2016) Dorothea Bankwitz et al.   HEPATOLOGY

Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity

(2016) Jannick Prentoe et al.   HEPATOLOGY

Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family

(2016) Donald B. Smith et al.   JOURNAL OF GENERAL VIROLOGY

The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control

(2016) Jens Bukh   JOURNAL OF HEPATOLOGY

A Hepatitis C Virus Envelope Polymorphism Confers Resistance to Neutralization by Polyclonal Sera and Broadly Neutralizing Monoclonal Antibodies

(2016) Lisa N. Wasilewski et al.   JOURNAL OF VIROLOGY

Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus

(2016) Zhen-yong Keck et al.   JOURNAL OF VIROLOGY

An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry

(2016) Kathleen McCaffrey et al.   JOURNAL OF VIROLOGY

TIM-1 Promotes Hepatitis C Virus Cell Attachment and Infection

(2016) Jing Wang et al.   JOURNAL OF VIROLOGY

Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus

(2016) Satomi Yamamoto et al.   PLoS Pathogens

HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

(2015) Jannick Prentoe et al.   GUT

Hepatitis C virus treatment in the real world: optimising treatment and access to therapies: Table 1

(2015) Fabien Zoulim et al.   GUT

Intensive temporal mapping of hepatitis C hypervariable region 1 quasispecies provides novel insights into hepatitis C virus evolution in chronic infection

(2015) Daniel Schmidt-Martin et al.   JOURNAL OF GENERAL VIROLOGY

From non-A, non-B hepatitis to hepatitis C virus cure

(2015) Jean-Michel Pawlotsky et al.   JOURNAL OF HEPATOLOGY

Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

(2015) Christian K. Mathiesen et al.   JOURNAL OF VIROLOGY

Network Analysis of the Chronic Hepatitis C Virome Defines Hypervariable Region 1 Evolutionary Phenotypes in the Context of Humoral Immune Responses

(2015) Brendan A. Palmer et al.   JOURNAL OF VIROLOGY

Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region

(2015) Yousef Alhammad et al.   JOURNAL OF VIROLOGY

Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses

(2014) William O. Osburn et al.   HEPATOLOGY

Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a

(2014) Thomas H.R. Carlsen et al.   HEPATOLOGY

Naturally selected hepatitis C virus polymorphisms confer broad neutralizing antibody resistance

(2014) Justin R. Bailey et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell Death-Inducing DFFA-Like Effector b Is Required for Hepatitis C Virus Entry into Hepatocytes

(2014) X. Wu et al.   JOURNAL OF VIROLOGY

Role of Hypervariable Region 1 for the Interplay of Hepatitis C Virus with Entry Factors and Lipoproteins

(2014) D. Bankwitz et al.   JOURNAL OF VIROLOGY

Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2

(2014) Abdul Ghafoor Khan et al.   NATURE

Hypervariable Region 1 Deletion and Required Adaptive Envelope Mutations Confer Decreased Dependency on Scavenger Receptor Class B Type I and Low-Density Lipoprotein Receptor for Hepatitis C Virus

(2013) J. Prentoe et al.   JOURNAL OF VIROLOGY

Syndecan-1 Serves as the Major Receptor for Attachment of Hepatitis C Virus to the Surfaces of Hepatocytes

(2013) Q. Shi et al.   JOURNAL OF VIROLOGY

Ultrastructural analysis of hepatitis C virus particles

(2013) Maria Teresa Catanese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis C Virus E2 Envelope Glycoprotein Core Structure

(2013) L. Kong et al.   SCIENCE

Characterization of Hepatitis C Virus Particle Subpopulations Reveals Multiple Usage of the Scavenger Receptor BI for Entry Steps

(2012) Viet Loan Dao Thi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three Different Functional Microdomains in the Hepatitis C Virus Hypervariable Region 1 (HVR1) Mediate Entry and Immune Evasion

(2012) Mo Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C Virus Attachment Mediated by Apolipoprotein E Binding to Cell Surface Heparan Sulfate

(2012) J. Jiang et al.   JOURNAL OF VIROLOGY

Cooperativity in Virus Neutralization by Human Monoclonal Antibodies to Two Adjacent Regions Located at the Amino Terminus of Hepatitis C Virus E2 Glycoprotein

(2012) Z. Keck et al.   JOURNAL OF VIROLOGY

Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor

(2012) Bruno Sainz et al.   NATURE MEDICINE

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

(2012) E. Giang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate

(2012) Zhen-yong Keck et al.   PLoS Pathogens

Role of low-density lipoprotein receptor in the hepatitis C virus life cycle

(2011) Anna Albecka et al.   HEPATOLOGY

Development and Application of Hepatitis C Reporter Viruses with Genotype 1 to 7 Core-Nonstructural Protein 2 (NS2) Expressing Fluorescent Proteins or Luciferase in Modified JFH1 NS5A

(2011) J. M. Gottwein et al.   JOURNAL OF VIROLOGY

Neutralizing Monoclonal Antibodies against Hepatitis C Virus E2 Protein Bind Discontinuous Epitopes and Inhibit Infection at a Postattachment Step

(2011) M. C. Sabo et al.   JOURNAL OF VIROLOGY

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

(2011) Joachim Lupberger et al.   NATURE MEDICINE

Production of Infectious Hepatitis C Virus in Primary Cultures of Human Adult Hepatocytes

(2010) Philippe Podevin et al.   GASTROENTEROLOGY

Biochemical and Morphological Properties of Hepatitis C Virus Particles and Determination of Their Lipidome

(2010) Andreas Merz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of antibody-mediated neutralization directed against the hypervariable region 1 of hepatitis C virus E2 glycoprotein

(2010) G. Vieyres et al.   JOURNAL OF GENERAL VIROLOGY

Role of N-Linked Glycans in the Functions of Hepatitis C Virus Envelope Proteins Incorporated into Infectious Virions

(2010) F. Helle et al.   JOURNAL OF VIROLOGY

Mutations within a Conserved Region of the Hepatitis C Virus E2 Glycoprotein That Influence Virus-Receptor Interactions and Sensitivity to Neutralizing Antibodies

(2010) S. Dhillon et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes

(2010) D. Bankwitz et al.   JOURNAL OF VIROLOGY

Hypervariable Region 1 Differentially Impacts Viability of Hepatitis C Virus Strains of Genotypes 1 to 6 and Impairs Virus Neutralization

(2010) J. Prentoe et al.   JOURNAL OF VIROLOGY

Hepatitis C virus expressing flag-tagged envelope protein 2 has unaltered infectivity and density, is specifically neutralized by flag antibodies and can be purified by affinity chromatography

(2010) Jannick Prentoe et al.   VIROLOGY

Selection Pressure From Neutralizing Antibodies Drives Sequence Evolution During Acute Infection With Hepatitis C Virus

(2009) Kimberly A. Dowd et al.   GASTROENTEROLOGY

The role of positive selection in hepatitis C virus

(2009) José M. Cuevas et al.   INFECTION GENETICS AND EVOLUTION

Apolipoprotein E but Not B Is Required for the Formation of Infectious Hepatitis C Virus Particles

(2009) J. Jiang et al.   JOURNAL OF VIROLOGY

Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

(2009) Alexander Ploss et al.   NATURE

A single point mutation in E2 enhances hepatitis C virus infectivity and alters lipoprotein association of viral particles

(2009) Wanyin Tao et al.   VIROLOGY

Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: Role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

(2008) Judith M. Gottwein et al.   HEPATOLOGY

Highly Efficient JFH1‐Based Cell‐Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing‐Antibody Treatment to Control Infection

(2008) Tanja B. Jensen et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies

(2008) J. Grove et al.   JOURNAL OF VIROLOGY

Previously Infected Chimpanzees Are Not Consistently Protected against Reinfection or Persistent Infection after Reexposure to the Identical Hepatitis C Virus Strain

(2008) J. Bukh et al.   JOURNAL OF VIROLOGY

Apolipoprotein C1 Association with Hepatitis C Virus

(2008) J.-C. Meunier et al.   JOURNAL OF VIROLOGY

Definition of a Conserved Immunodominant Domain on Hepatitis C Virus E2 Glycoprotein by Neutralizing Human Monoclonal Antibodies

(2008) Z.-Y. Keck et al.   JOURNAL OF VIROLOGY

Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

(2008) T. K. H. Scheel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA