Review
Oncology
Ruth M. Urbantat, Peter Vajkoczy, Susan Brandenburg
Summary: Chemokine signaling plays a crucial role in glioblastoma, potentially serving as therapeutic targets for new treatment regimens. Further research and clinical studies are needed to explore the efficacy of these novel chemokine-targeting therapies.
Review
Cell Biology
Conor Hennessy, Declan P. McKernan
Summary: PRRs play a central role in inflammation following microbial infection by recognizing molecular patterns, and targeting them may offer a potential therapeutic approach for chronic inflammatory diseases and infections.
Review
Immunology
Masanori A. Murayama, Jun Shimizu, Chie Miyabe, Kazuo Yudo, Yoshishige Miyabe
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-alpha, play crucial roles in RA development. Biological therapies targeting these cytokines have revolutionized RA treatment, but non-responsiveness is still a challenge. This review focuses on the pathogenic roles of chemokines and their receptors in RA and discusses their potential as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Applied
Wenwei Han, Youjing Lv, Yutong Sun, Yingdi Wang, Zhan Zhao, Chuanqin Shi, Xiangyan Chen, Li Wang, Meifang Zhang, Bo Wei, Xia Zhao, Xin Wang
Summary: Hyaluronic acid exhibits dual effects on inflammation, with different sizes and structures of HA oligosaccharides and derivatives having varying impacts on inflammation, where HA disaccharide can competitively block TLR4-dependent inflammation.
CARBOHYDRATE POLYMERS
(2022)
Review
Immunology
Lin Wang, Chengqi He
Summary: Macrophages in synovial joints play an important role in the pathological process of osteoarthritis (OA). Their transition between pro-inflammatory and anti-inflammatory phenotypes can impact the intra-articular microenvironment. The inhibition of NF-kappa B signaling pathway is crucial in OA treatment, while the activation of Nrf2 signaling pathway, which has antioxidant and anti-inflammatory effects, and its crosstalk with NF-kappa B pathway have received less attention. Activating Nrf2 can inhibit M1 polarization and promote M2 polarization through multiple signaling pathways. Various potential candidates for activating Nrf2 to promote M2 phenotype macrophages in OA treatment are discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Cameron R. Bastow, Mark D. Bunting, Ervin E. Kara, Duncan R. McKenzie, Adriana Caon, Sapna Devi, Lynn Tolley, Scott N. Mueller, Ian H. Frazer, Natasha Harvey, Mark R. Condina, Clifford Young, Peter Hoffmann, Shaun R. McColl, Iain Comerford
Summary: This study reveals the mechanism by which ACKR4 controls DC migration in barrier tissues, identifying the existence of two forms of CCL21 in steady-state conditions and their regulation by ACKR4. It enhances understanding of functional chemokine gradient formation by showing how ACKR4 affects CCL21 gradients in barrier tissues and downstream lymph nodes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Selin Gencer, Bryce R. Evans, Emiel P. C. van der Vorst, Yvonne Doering, Christian Weber
Summary: Atherosclerosis is a chronic inflammatory disease of the vessel wall leading to occlusive lesions in large arteries. Chemokines and their receptors play a key role in the development of atherosclerotic lesions by orchestrating immune cell activation and recruitment. Recent research has focused on targeting these chemokines for potential treatment of atherosclerosis.
Article
Chemistry, Medicinal
Yi Dong, Rong Fu, Jiajing Chen, Kehui Zhang, Ming Ji, Mingjin Wang, Huimin Jiang, Wei Ye, Jinping Hu, Yan Li, Jing Jin, Xiaoguang Chen, Heng Xu
Summary: The study designed benzocyclic sulfone derivatives as potent CXCR2 antagonists, with lead compounds 9b and 11h showing high inhibitory effects on tumor growth in the Pan02 mouse model through oral administration. They also reduced neutrophils and MDSCs infiltration while enhancing CD3(+) T lymphocytes infiltration into tumor tissues.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Shaun C. Moore, Pedro A. S. Vaz de Castro, Daniel Yaqub, Pedro A. Jose, Ines Armando
Summary: This article focuses on the synthesis of dopamine in the nervous system as a neurotransmitter, its synthesis in peripheral organs and cells, and its role in regulating the inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ashok Kumar, Vihang A. Narkar
Summary: This review proposes nuclear receptors as potential candidates for ischemic muscle repair in peripheral arterial disease (PAD), focusing on their roles in muscle angiogenesis, oxidative metabolism, mitochondrial biogenesis, and muscle regeneration. The article also identifies gaps in our understanding of nuclear receptor signaling in skeletal muscle and suggests future research directions.
Article
Neurosciences
Si-Si Jiang, Yi-Ling Wang, Qiu-Han Xu, Lu-Yan Gu, Rui-Qing Kang, Wen-Yi Yang, Bao-Rong Zhang, Jun Tian, Jia-Li Pu
Summary: Peripheral immune cells, specifically CD8(+) T cells and NK cells, in patients with Parkinson's disease (PD) exhibit disrupted secretion of pro-inflammatory cytokines and chemokines, such as TNF-& alpha;, IL-8, IL-1 & beta;, and CCL17. These cytokines and cell clusters are associated with clinical symptoms, including cognitive impairment and motor symptoms. The levels of intracellular TNF-& alpha; in CD8(+) T cells and NK cells are negatively correlated with cognitive assessment scores and positively correlated with the severity of motor symptoms. This study provides important insights into the role of peripheral immune cells in PD pathogenesis.
NPJ PARKINSONS DISEASE
(2023)
Review
Oncology
Charlise Basson, June Cheptoo Serem, Priyesh Bipath, Yvette Nkondo Hlophe
Summary: This article discusses the pathological characteristics of cutaneous melanoma, which is becoming increasingly prevalent, as well as the use of chemotherapy in the treatment of cutaneous melanoma. It is found that the activation of chemokine axes plays an important role in the metastasis of melanoma, so intervention targeting these axes can be considered in the treatment of melanoma. Experimental results have shown that targeting chemokine axes can inhibit the migration, proliferation, and survival of tumor cells, thereby slowing down the metastasis and progression of melanoma.
Review
Pharmacology & Pharmacy
Jamal Tazi, Christina Begon-Pescia, Noelie Campos, Cecile Apolit, Aude Garcel, Didier Scherrer
Summary: Inflammatory diseases are believed to result from dysregulated inflammatory responses to environmental factors on susceptible genetic backgrounds. MiRNAs, such as miR-124, are endogenous, small noncoding RNAs that play a role in regulating gene expression involved in inflammation. ABX464, a small quinoline compound, has shown promising efficacy in ulcerative colitis by upregulating miR-124 and restoring physiological pathways lost in inflammatory diseases.
DRUG DISCOVERY TODAY
(2021)
Article
Medicine, General & Internal
Jie Chen, Fengzhe Xu, Xixian Ruan, Jing Sun, Yao Zhang, Han Zhang, Jianhui Zhao, Jie Zheng, Susanna C. Larsson, Xiaoyan Wang, Xue Li, Shuai Yuan
Summary: A proteome-wide investigation using Mendelian randomization and colocalization analysis identified several proteins associated with the risk of inflammatory bowel disease. MST1, HGFAC, STAT3, ITPKA, and CXCL5 may serve as potential therapeutic targets for the disease.
Article
Chemistry, Multidisciplinary
Jun Yan, Yunjing Wan, Zhe Ji, Chenxi Li, Chengcheng Tao, Yunjiao Tang, Yuze Zhang, Yaobo Liu, Jian Liu
Summary: This study reports a new concept of using near infrared (NIR) laser-triggered optogenetics to promote the functional recovery and regeneration of transected peripheral nerves. The approach involves the use of acetylcholine-modified upconversion nanoparticles (UCNP) to activate channelrhodopsin 2 (ChR2) protein on the acetylcholinergic motor neurons. This leads to a cascade of events that promote axonal regeneration, remyelination of Schwann cells, enhanced expression of brain-derived neurotrophic factor, and remodeling of neuromuscular junctions (NMJ).
ADVANCED FUNCTIONAL MATERIALS
(2023)
