Specific and selective induction of miR-124 in immune cells by the quinoline ABX464: a transformative therapy for inflammatory diseases

Translating IL-6 biology into effective treatments

(2020) Ernest H. Choy et al.   Nature Reviews Rheumatology

Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing

(2019) Audrey Vautrin et al.   Scientific Reports

OP21 ABX464 is safe and efficacious in a proof-of-concept study in ulcerative colitis patients

(2019) S Vermeire et al.   Journal of Crohns & Colitis

Efficacy and Safety of Mirikizumab in a Randomized Phase 2 Study of Patients With Ulcerative Colitis

(2019) William J. Sandborn et al.   GASTROENTEROLOGY

Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2019) Bruce E. Sands et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment

(2018) Alireza Tahamtan et al.   Frontiers in Immunology

The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages

(2017) Karim Chebli et al.   Scientific Reports

Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Downregulated expression of microRNA-124 in pediatric intestinal failure patients modulates macrophages activation by inhibiting STAT3 and AChE

(2016) Yong-Tao Xiao et al.   Cell Death & Disease

miRNA-124 in Immune System and Immune Disorders

(2016) Zhen Qin et al.   Frontiers in Immunology

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

(2015) Jamie B. Spangler et al.   Annual Review of Immunology

Long lasting control of viral rebound with a new drug ABX464 targeting Rev – mediated viral RNA biogenesis

(2015) Noëlie Campos et al.   Retrovirology

RNA degradation in antiviral immunity and autoimmunity

(2015) Rachel E. Rigby et al.   TRENDS IN IMMUNOLOGY

TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future

(2014) Lisa M. Sedger et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNFα therapy

(2014) Raquel Franco Leal et al.   GUT

IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis

(2014) L. Skov et al.   JOURNAL OF IMMUNOLOGY

MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways

(2014) Xiaobing He et al.   Biomed Research International

Cap-binding complex (CBC)

(2013) Thomas Gonatopoulos-Pournatzis et al.   BIOCHEMICAL JOURNAL

MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines

(2013) Yang Sun et al.   CELL RESEARCH

MicroRNA-124 Regulates STAT3 Expression and Is Down-regulated in Colon Tissues of Pediatric Patients With Ulcerative Colitis

(2013) Georgios Koukos et al.   GASTROENTEROLOGY

Regulation of miRNA biogenesis and turnover in the immune system

(2013) Yelena Bronevetsky et al.   IMMUNOLOGICAL REVIEWS

Regulation of immune responses and tolerance: the microRNA perspective

(2013) Chang-Zheng Chen et al.   IMMUNOLOGICAL REVIEWS

The human cap-binding complex is functionally connected to the nuclear RNA exosome

(2013) Peter Refsing Andersen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease

(2013) Mehmet Coskun et al.   PHARMACOLOGICAL RESEARCH

IL-4/IL-13-Dependent and Independent Expression of miR-124 and Its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and during Allergic Inflammation

(2013) Tatyana Veremeyko et al.   PLoS One

microRNA Regulation of Inflammatory Responses

(2012) Ryan M. O'Connell et al.   Annual Review of Immunology

Dysregulation of immune homeostasis in autoimmune diseases

(2012) Vijay K Kuchroo et al.   NATURE MEDICINE

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

MicroRNAs and the resolution phase of inflammation in macrophages

(2011) Muhammad M. Alam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CXCR3 in T cell function

(2011) Joanna R. Groom et al.   EXPERIMENTAL CELL RESEARCH

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex

(2011) Michal Lubas et al.   MOLECULAR CELL

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

(2010) Li-Fan Lu et al.   CELL

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2009) Yuji Nakamachi et al.   ARTHRITIS AND RHEUMATISM

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

microRNAs and the immune response

(2009) Eleni Tsitsiou et al.   CURRENT OPINION IN PHARMACOLOGY

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis

(2009) I. Arijs et al.   GUT

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

MicroRNAs: new regulators of immune cell development and function

(2008) David Baltimore et al.   NATURE IMMUNOLOGY