Conditions for palladium-catalyzed direct arylations of 4-bromo and 4-iodo N-substituted pyrazoles without C–Br or C–I bond cleavage

Functionalization of C–H Bonds via Metal-Catalyzed Desulfitative Coupling: An Alternative Tool for Access to Aryl- or Alkyl-Substituted (Hetero)arenes

(2015) Kedong Yuan et al.   ACS Catalysis

Selective Palladium-Catalyzed Direct CH Arylation of UnsubstitutedN-Protected Pyrazoles

(2014) Esa T. T. Kumpulainen et al.   ADVANCED SYNTHESIS & CATALYSIS

Cross-Coupling of Heteroarenes by CH Functionalization: Recent Progress towards Direct Arylation and Heteroarylation Reactions Involving Heteroarenes Containing One Heteroatom

(2014) Renzo Rossi et al.   ADVANCED SYNTHESIS & CATALYSIS

Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel

(2014) Michael P. Winters et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

C-H Arylation of Nitroimidazoles and Nitropyrazoles Guided by the Electronic Effect of the Nitro Group

(2014) Haeun Jung et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Synthesis of (Poly)fluorobiphenyls through Metal-catalyzed CH Bond Activation/Arylation of (Poly)fluorobenzene Derivatives

(2014) Mian He et al.   ChemCatChem

Formyl Substituent at C-4 of Pyrazoles: A Temporary Protecting Group for Regioselective Palladium-Catalyzed Direct Arylation at C-5

(2014) Imen Smari et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

(2014) Ted W. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Facile Synthetic Method for Diverse Polyfunctionalized Imidazoles by Means of Pd-Catalyzed C–H Bond Arylation of N-Methyl-4,5-dibromoimidazole

(2014) Takayuki Yamauchi et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective and Guided C–H Activation of 4-Nitropyrazoles

(2014) Viktor O. Iaroshenko et al.   JOURNAL OF ORGANIC CHEMISTRY

A General Suzuki Cross-Coupling Reaction of Heteroaromatics Catalyzed by Nanopalladium on Amino-Functionalized Siliceous Mesocellular Foam

(2014) Emma Bratt et al.   JOURNAL OF ORGANIC CHEMISTRY

Suzuki-Miyaura Cross-Coupling Reactions of Unprotected Haloimidazoles

(2014) Jiajing Tan et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-catalysed direct diarylations of pyrazoles with aryl bromides: a one step access to 4,5-diarylpyrazoles

(2014) Abdelilah Takfaoui et al.   TETRAHEDRON LETTERS

Highly Hydrophobic Isoreticular Porous Metal-Organic Frameworks for the Capture of Harmful Volatile Organic Compounds

(2013) Natalia M. Padial et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mild Palladium-Catalyzed Regioselective Direct Arylation of Azoles Promoted by Tetrabutylammonium Acetate

(2013) Fabio Bellina et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand

(2013) Lei Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nickel-Catalyzed Suzuki–Miyaura Couplings in Green Solvents

(2013) Stephen D. Ramgren et al.   ORGANIC LETTERS

Dihydropyrrolo[1,2-b]pyrazoles: withasomnine and related compounds

(2013) Juraj Galeta et al.   TETRAHEDRON

Enhanced heterogeneously catalyzed Suzuki–Miyaura reaction over SiliaCat Pd(0)

(2013) Valerica Pandarus et al.   TETRAHEDRON LETTERS

Improved Air-Stable Solid Aromatic and Heterocyclic Zinc Reagents by Highly Selective Metalations for Negishi Cross-Couplings

(2012) Christos I. Stathakis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Beyond Directing Groups: Transition-Metal-Catalyzed CH Activation of Simple Arenes

(2012) Nadine Kuhl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preparation and Chemistry of 3/5-Halogenopyrazoles

(2012) Yves L. Janin   CHEMICAL REVIEWS

From C(sp2)–H to C(sp3)–H: systematic studies on transition metal-catalyzed oxidative C–C formation

(2012) Bi-Jie Li et al.   CHEMICAL SOCIETY REVIEWS

[Pd(IPr*)(cinnamyl)Cl]: An Efficient Pre-catalyst for the Preparation of Tetra-ortho-substituted Biaryls by Suzuki-Miyaura Cross-Coupling

(2012) Anthony Chartoire et al.   CHEMISTRY-A EUROPEAN JOURNAL

Origins of regioselectivity of the palladium-catalyzed (aromatic)CH bond metalation–deprotonation

(2012) Serge I. Gorelsky   COORDINATION CHEMISTRY REVIEWS

Palladium-Catalyzed Direct Arylation of 5-Chloropyrazoles: A Selective Access to 4-Aryl Pyrazoles

(2012) Tao Yan et al.   JOURNAL OF ORGANIC CHEMISTRY

Few unexpected results from a Suzuki–Miyaura reaction

(2012) Elise Salanouve et al.   TETRAHEDRON

Challenges in C–C bond formation through direct transformations of sp2 C–H bonds

(2012) Da-Gang Yu et al.   TETRAHEDRON

Ruthenium-catalyzed direct oxidative alkenylation of arenes through twofold C–H bond functionalization

(2012) Sergei I. Kozhushkov et al.   Chemical Science

Discovery of a 4-Azetidinyl-1-thiazoyl-cyclohexane CCR2 Antagonist as a Development Candidate

(2012) Xuqing Zhang et al.   ACS Medicinal Chemistry Letters

Palladium-Catalyzed Direct Arylation of Heteroaromatics with Activated Aryl Chlorides Using a Sterically Relieved Ferrocenyl-Diphosphane

(2012) David Roy et al.   ACS Catalysis

Recent advances in the transition metal-catalyzed twofold oxidative C–H bond activation strategy for C–C and C–N bond formation

(2011) Seung Hwan Cho et al.   CHEMICAL SOCIETY REVIEWS

Recent Progress in Coupling of Two Heteroarenes

(2011) Dongbing Zhao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium-Catalyzed Direct Arylations of Five-Membered Heteroarenes Bearing N-Monoalkylcarboxamide Substituents

(2011) Nouria Laidaoui et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Direct Arylation of Simple Azoles Catalyzed by 1,10-Phenanthroline Containing Palladium Complexes: An Investigation of C4 Arylation of Azoles and the Synthesis of Triarylated Azoles by Sequential Arylation

(2011) Fumitoshi Shibahara et al.   JOURNAL OF ORGANIC CHEMISTRY

Suzuki–Miyaura reactions of N-protected tribromopyrazoles. Efficient and site-selective synthesis of 3,4,5-triaryl-pyrazoles, 3,5-diaryl-4-bromopyrazoles and 5-aryl-3,4-dibromopyrazoles

(2011) Rasheed Ahmad Khera et al.   TETRAHEDRON

Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks

(2011) Sandrine Guillou et al.   TETRAHEDRON

Pd-catalyzed oxidative coupling with organometallic reagents via C–H activation

(2010) Chang-Liang Sun et al.   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Modulating Reactivity and Diverting Selectivity in Palladium-Catalyzed Heteroaromatic Direct Arylation Through the Use of a Chloride Activating/Blocking Group

(2010) Benoît Liégault et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Palladium-Catalyzed Arylation of 4-Chloropyrazoles

(2010) Carlos Mateos et al.   ORGANIC LETTERS

Transition-Metal-Catalyzed Regioselective Arylation and Vinylation of Carboxylic Acids

(2010) Tetsuya Satoh et al.   SYNTHESIS-STUTTGART

Transition-Metal-Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage

(2009) Lutz Ackermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed C3 or C4 Direct Arylation of Heteroaromatic Compounds with Aryl Halides by CH Bond Activation

(2009) Julien Roger et al.   ChemCatChem

Transition Metal-Catalyzed Direct Arylation of Substrates with Activated sp3-Hybridized C−H Bonds and Some of Their Synthetic Equivalents with Aryl Halides and Pseudohalides

(2009) Fabio Bellina et al.   CHEMICAL REVIEWS

A Preparatively Convenient Ligand-Free Catalytic PEG 2000 Suzuki−Miyaura Coupling

(2009) Thomas M. Razler et al.   JOURNAL OF ORGANIC CHEMISTRY

C−H Bonds as Ubiquitous Functionality: A General Approach to Complex Arylated Pyrazoles via Sequential RegioselectiveC-Arylation andN-Alkylation Enabled by SEM-Group Transposition

(2009) Roman Goikhman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Arylations of 2H-Indazoles On Water

(2009) Stephan A. Ohnmacht et al.   ORGANIC LETTERS

Recent advances in the synthesis of (hetero)aryl-substituted heteroarenes via transition metal-catalysed direct (hetero)arylation of heteroarene C–H bonds with aryl halides or pseudohalides, diaryliodonium salts, and potassium aryltrifluoroborates

(2009) Fabio Bellina et al.   TETRAHEDRON

Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists

(2008) Gavin A. Whitlock et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development and Application of Effective Protocols for the Synthesis of Arylheteroarenes and Biheteroaryls, Including Bioactive Derivatives, by Highly Regioselective Transition Metal-Catalyzed Direct Intermolecular Arylation Reactions of Five-Membered Heteroarenes with (Hetero)aryl Halides

(2008) Fabio Bellina et al.   CURRENT ORGANIC CHEMISTRY

Transition-Metal-Catalyzed Carbon-Carbon Bond Formation via Carbon-Hydrogen Bond Cleavage

(2008) Fumitoshi Kakiuchi et al.   SYNTHESIS-STUTTGART