Targeting ion channels for the treatment of autoimmune neuroinflammation

Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride

(2013) Tarunya Arun et al.   BRAIN

Targeting two-pore domain potassium channels — A promising strategy for treating T cell mediated autoimmunity

(2013) Bernd C. Kieseier et al.   EXPERIMENTAL NEUROLOGY

Lipopolysaccharide-sensitive H+ current in dendritic cells

(2012) Kalina Szteyn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neurological perspectives on voltage-gated sodium channels

(2012) N. Eijkelkamp et al.   BRAIN

Expression and Functional Significance of the Ca2+-Activated Cl-Channel ANO6 in Dendritic Cells

(2012) Kalina Szteyn et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Use of Aminopyridines in Neurological Disorders

(2012) Saam Sedehizadeh et al.   CLINICAL NEUROPHARMACOLOGY

The TASK1 channel inhibitor A293 shows efficacy in a mouse model of multiple sclerosis

(2012) Stefan Bittner et al.   EXPERIMENTAL NEUROLOGY

Neuromyelitis optica: Aquaporin-4 based pathogenesis mechanisms and new therapies

(2012) Julien Ratelade et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves

(2012) Aleksandra Ivanovic et al.   JOURNAL OF CELL BIOLOGY

Kv1.3 Deletion Biases T Cells toward an Immunoregulatory Phenotype and Renders Mice Resistant to Autoimmune Encephalomyelitis

(2012) A. R. Gocke et al.   JOURNAL OF IMMUNOLOGY

Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity

(2012) Patrick J. Shaw et al.   JOURNAL OF PHYSIOLOGY-LONDON

A voltage-gated sodium channel is essential for the positive selection of CD4+ T cells

(2012) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

(2012) Benjamin Schattling et al.   NATURE MEDICINE

K+ channel alterations in the progression of experimental autoimmune encephalomyelitis

(2012) Peter I. Jukkola et al.   NEUROBIOLOGY OF DISEASE

Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis

(2012) Rajneesh Srivastava et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells

(2011) Joo Hyun Nam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ca2+ signaling in the regulation of dendritic cell functions

(2011) Ekaterina Shumilina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Calcium-Activated Potassium Channel KCa3.1 in Lung Dendritic Cell Migration

(2011) Zhifei Shao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis

(2011) Shannon D. Shields et al.   ANNALS OF NEUROLOGY

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

(2011) Sandra Vergo et al.   BRAIN

Ion Channels on Microglia: Therapeutic Targets for Neuroprotection

(2011) Stephen D. Skaper   CNS & Neurological Disorders-Drug Targets

Dalfampridine: a brief review of its mechanism of action and efficacy as a treatment to improve walking in patients with multiple sclerosis

(2011) Jeffrey Dunn et al.   CURRENT MEDICAL RESEARCH AND OPINION

The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression

(2011) Jenny Lam et al.   DRUG DEVELOPMENT RESEARCH

Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release

(2011) Adriana Sumoza-Toledo et al.   FASEB JOURNAL

Ion channels in autoimmune neurodegeneration

(2011) Petra Ehling et al.   FEBS LETTERS

The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production

(2011) Masanori Matsumoto et al.   IMMUNITY

Clustering and Activity Tuning of Kv1 Channels in Myelinated Hippocampal Axons

(2011) Chen Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acid-Sensing Ion Channels Contribute to the Effect of Acidosis on the Function of Dendritic Cells

(2011) J. Tong et al.   JOURNAL OF IMMUNOLOGY

Voltage-Gated Sodium Channel Nav1.7 Maintains the Membrane Potential and Regulates the Activation and Chemokine-Induced Migration of a Monocyte-Derived Dendritic Cell Subset

(2011) K. Kis-Toth et al.   JOURNAL OF IMMUNOLOGY

Neuromyelitis optica and astrocytic damage in its pathogenesis

(2011) Kazuo Fujihara   JOURNAL OF THE NEUROLOGICAL SCIENCES

Role of aquaporin 3 in development, subtypes and activation of dendritic cells

(2011) Min-Gyu Song et al.   MOLECULAR IMMUNOLOGY

Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients

(2011) Stefan Bittner et al.   ARTHRITIS RESEARCH & THERAPY

Effect of K+ channel blockers on the clinical course and histological features of experimental allergic encephalomyelitis

(2010) B. M. J. Uitdehaag et al.   ACTA NEUROLOGICA SCANDINAVICA

Upregulation of K2P5.1 potassium channels in multiple sclerosis

(2010) Stefan Bittner et al.   ANNALS OF NEUROLOGY

A phase 3 trial of extended release oral dalfampridine in multiple sclerosis

(2010) Andrew D. Goodman et al.   ANNALS OF NEUROLOGY

Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI

(2010) Patrick G. Hogan et al.   Annual Review of Immunology

Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5

(2010) J. A. Black et al.   BRAIN

From the Background to the Spotlight: TASK Channels in Pathological Conditions

(2010) Stefan Bittner et al.   BRAIN PATHOLOGY

T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells

(2010) Jian Ma et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Store-Operated Ca2+ Entry through ORAI1 Is Critical for T Cell-Mediated Autoimmunity and Allograft Rejection

(2010) C.-A. McCarl et al.   JOURNAL OF IMMUNOLOGY

Store-operated Ca2+ signaling in dendritic cells occurs independently of STIM1

(2010) Bidhan C. Bandyopadhyay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial

(2010) Raju Kapoor et al.   LANCET NEUROLOGY

Neuromyelitis optica: a demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes

(2010) John DE Parratt et al.   Multiple Sclerosis Journal

Astrocytic damage is far more severe than demyelination in NMO: A clinical CSF biomarker study

(2010) R. Takano et al.   NEUROLOGY

Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis

(2010) L. Di et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the large-conductance background K+ channel in mouse B cells as TREK-2

(2009) Haifeng Zheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system

(2009) Stefan Bittner et al.   BRAIN

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Developmental Switch of the Expression of Ion Channels in Human Dendritic Cells

(2009) E. Zsiros et al.   JOURNAL OF IMMUNOLOGY

Stromal Interaction Molecules 1 and 2 Are Key Regulators of Autoreactive T Cell Activation in Murine Autoimmune Central Nervous System Inflammation

(2009) M. K. Schuhmann et al.   JOURNAL OF IMMUNOLOGY

Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial

(2009) Andrew D Goodman et al.   LANCET

Inositol trisphosphate and calcium signalling mechanisms

(2008) Michael J. Berridge   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Membrane water permeability related to antigen-presenting function of dendritic cells

(2008) G. F. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

KCa3.1: target and marker for cancer, autoimmune disorder and vascular inflammation?

(2008) Chuan-Chu Chou et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

TWIK-related Acid-sensitive K+Channel 1 (TASK1) and TASK3 Critically Influence T Lymphocyte Effector Functions

(2008) Sven G. Meuth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ryanodine Receptor Activation by Cav1.2 Is Involved in Dendritic Cell Major Histocompatibility Complex Class II Surface Expression

(2008) Mirko Vukcevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Receptor Potential Vanilloid-1 Signaling as a Regulator of Human Sebocyte Biology

(2008) Balázs I. Tóth et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Multiple Molecular Interactions Determine the Clustering of Caspr2 and Kv1 Channels in Myelinated Axons

(2008) I. Horresh et al.   JOURNAL OF NEUROSCIENCE

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1

(2008) Y. Gwack et al.   MOLECULAR AND CELLULAR BIOLOGY

P2X7 Receptors in Oligodendrocytes: A Novel Target for Neuroprotection

(2008) Carlos Matute   MOLECULAR NEUROBIOLOGY

The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells

(2008) Gaëtan Barbet et al.   NATURE IMMUNOLOGY

Amiloride is neuroprotective in an MPTP model of Parkinson's disease

(2008) Robert L. Arias et al.   NEUROBIOLOGY OF DISEASE

Mechanisms of Disease: sodium channels and neuroprotection in multiple sclerosis—current status

(2008) Stephen G Waxman   Nature clinical practice. Neurology

Glutamate Receptor Expression in Multiple Sclerosis Lesions

(2007) Jia Newcombe et al.   BRAIN PATHOLOGY

Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases

(2007) Z XIONG et al.   CURRENT OPINION IN PHARMACOLOGY